Detailed information NTG0235428

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SE071780_RS05180
• Genome accession: NZ_CP021972
• Coordinates: 1044109..1044783 (+)
• Length: 224 a.a.
• NCBI ID: WP_012515548.1
• Uniprot ID: B4U2R0
• Organism: Streptococcus equi subsp. equi strain ATCC 39506
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1039109..1049783

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SE071780_RS05165 (SE071780_01078)	pstB	1039437..1040195 (+)	759	WP_012678019.1	phosphate ABC transporter ATP-binding protein PstB	-
SE071780_RS05170 (SE071780_01079)	phoU	1040266..1040919 (+)	654	WP_012679476.1	phosphate signaling complex protein PhoU	-
SE071780_RS05175 (SE071780_01080)	-	1041153..1043690 (+)	2538	WP_012679477.1	M1 family metallopeptidase	-
SE071780_RS05180 (SE071780_01081)	ciaR	1044109..1044783 (+)	675	WP_012515548.1	response regulator transcription factor	Regulator
SE071780_RS05185 (SE071780_01082)	ciaH	1044776..1046086 (+)	1311	WP_042356911.1	HAMP domain-containing sensor histidine kinase	Regulator
SE071780_RS05190 (SE071780_01083)	-	1046471..1046890 (+)	420	WP_012679479.1	hypothetical protein	-
SE071780_RS05195 (SE071780_01084)	-	1046887..1048080 (+)	1194	WP_042356913.1	hypothetical protein	-
SE071780_RS05200 (SE071780_01085)	-	1048077..1048469 (+)	393	WP_012679481.1	hypothetical protein	-
SE071780_RS05205 (SE071780_01086)	-	1048488..1048772 (+)	285	WP_012679482.1	hypothetical protein	-
SE071780_RS05210 (SE071780_01087)	rpsT	1048971..1049219 (-)	249	WP_012679483.1	30S ribosomal protein S20	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25541.52 Da
• Isoelectric Point: 4.5644

>NTDB_id=235428 SE071780_RS05180 WP_012515548.1 1044109..1044783(+) (ciaR) [Streptococcus equi subsp. equi strain ATCC 39506]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQAIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide

• Length: 675 bp

>NTDB_id=235428 SE071780_RS05180 WP_012515548.1 1044109..1044783(+) (ciaR) [Streptococcus equi subsp. equi strain ATCC 39506]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTGTCAAATTCTATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACGCAGGTTTTTGATGGTGACGAAGGACTCTATGAGGCAGAAAGCGGTATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGTTAAAAGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATCGATGACAAAGGGCATGGCTTTGAGCTTGGTGCTGATGACTATTTAACCAAGCCCTTTTACCTAGAAGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGCGTAGGAAAGTTTAATGACAAGAGCCTTAAATTTGGCAACCTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGCCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAATCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATTCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: B4U2R0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae Rx1	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae D39	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae R6	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae TIGR4	80.543	98.661	0.795
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.428	100	0.393
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362