Detailed information NTG0235243

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: SPV_RS06185
• Genome accession: NZ_CP027540
• Coordinates: 1189486..1190127 (-)
• Length: 213 a.a.
• NCBI ID: WP_000151458.1
• Uniprot ID: Q8DPF9
• Organism: Streptococcus pneumoniae strain D39V
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1184486..1195127

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPV_RS06150 (SPV_1154)	-	1184599..1184841 (+)	243	WP_000710764.1	type B 50S ribosomal protein L31	-
SPV_RS06155 (SPV_1155)	-	1184898..1185476 (-)	579	WP_000252103.1	hypothetical protein	-
SPV_RS06160 (SPV_1156)	efeB	1185451..1186464 (-)	1014	Protein_1170	iron uptake transporter deferrochelatase/peroxidase subunit	-
SPV_RS06165 (SPV_2318)	-	1186434..1186925 (-)	492	Protein_1171	winged helix-turn-helix domain-containing protein	-
SPV_RS06170 (SPV_1158)	gdhA	1187461..1188807 (+)	1347	WP_000199534.1	NADP-specific glutamate dehydrogenase	-
SPV_RS11390 (SPV_1159)	-	1189303..1189473 (-)	171	WP_000711943.1	hypothetical protein	-
SPV_RS06185 (SPV_1160)	comA	1189486..1190127 (-)	642	WP_000151458.1	ATP-binding cassette domain-containing protein	Regulator
SPV_RS12045	-	1190252..1190438 (-)	187	Protein_1175	hypothetical protein	-
SPV_RS10965 (SPV_2319)	-	1190399..1190836 (+)	438	WP_001856204.1	hypothetical protein	-
SPV_RS11710	-	1190838..1190906 (+)	69	WP_225208679.1	hypothetical protein	-
SPV_RS06200 (SPV_1162)	-	1191127..1191321 (-)	195	Protein_1178	ROK family protein	-
SPV_RS06205 (SPV_2320)	-	1191348..1192265 (-)	918	Protein_1179	dihydrodipicolinate synthase family protein	-
SPV_RS06210 (SPV_1164)	-	1192297..1192704 (-)	408	WP_000216067.1	cytidine deaminase	-
SPV_RS06215 (SPV_1165)	-	1192992..1193480 (-)	489	WP_000872894.1	phosphatidylglycerophosphatase A	-
SPV_RS06220 (SPV_1166)	-	1193485..1194894 (-)	1410	WP_000773464.1	hypothetical protein	-

Sequence

Protein

• Length: 213 a.a.
• Molecular weight: 23486.26 Da
• Isoelectric Point: 9.2387

>NTDB_id=235243 SPV_RS06185 WP_000151458.1 1189486..1190127(-) (comA) [Streptococcus pneumoniae strain D39V]
MTIEPGQRIALVGQSGSGKSTLSKIPSGLYKIDTGKVLFDGVNINQIDKKILSQNLGVVPQDSFLLNRSILDNITLKHEV
TSQKIEEVCKAVQIYDEIMAMPMKFNTIISEMGSNISGGQRQRIALARALINNPSIVILDEATSALDTINEERITKYIKS
QGCTQIIVAHRLSTIKDADIIVVMKGGKIVESGNHKYLMDLGGEYYSLYTKRK

Nucleotide

• Length: 642 bp

>NTDB_id=235243 SPV_RS06185 WP_000151458.1 1189486..1190127(-) (comA) [Streptococcus pneumoniae strain D39V]
TTGACTATTGAGCCAGGACAGAGAATTGCACTAGTCGGTCAATCGGGGTCAGGAAAAAGTACGTTATCAAAAATACCATC
AGGATTATATAAGATTGATACAGGAAAAGTTTTATTTGATGGTGTAAATATTAATCAAATAGATAAAAAAATATTAAGTC
AAAATTTAGGAGTAGTTCCACAGGATTCGTTTTTATTGAACAGAAGTATTCTTGATAACATAACTTTAAAGCACGAAGTT
ACTTCACAAAAGATAGAGGAAGTTTGTAAAGCAGTTCAAATCTATGATGAAATCATGGCTATGCCGATGAAATTTAATAC
TATCATCTCAGAGATGGGTTCAAATATTTCAGGTGGTCAAAGACAACGGATAGCACTGGCACGTGCATTAATAAATAATC
CTAGTATTGTAATTTTAGATGAAGCAACTAGTGCTTTAGACACTATTAATGAGGAAAGAATAACAAAGTATATAAAAAGT
CAGGGCTGTACTCAAATAATTGTAGCTCATAGATTGTCAACGATTAAGGATGCGGATATTATTGTTGTAATGAAAGGTGG
TAAGATTGTTGAGTCAGGAAATCATAAGTACTTAATGGATCTTGGTGGAGAGTACTACAGCTTATATACAAAAAGGAAAT
GA

Domains

Predicted by InterProScan.

• ABC transporter (ABC_tran) (1-144)

3D structure

• AlphaFold DB: Q8DPF9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	43.81	98.592	0.432
comA	Streptococcus mitis SK321	43.333	98.592	0.427
comA	Streptococcus gordonii str. Challis substr. CH1	42.453	99.531	0.423
comA/nlmT	Streptococcus mutans UA159	42.453	99.531	0.423
comA	Streptococcus pneumoniae R6	42.381	98.592	0.418
comA	Streptococcus pneumoniae Rx1	42.381	98.592	0.418
comA	Streptococcus pneumoniae D39	42.381	98.592	0.418
comA	Streptococcus pneumoniae TIGR4	41.429	98.592	0.408
rcrQ	Streptococcus mutans UA159	36.62	100	0.366