Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   CCE29_RS10220 Genome accession   NZ_CP021426
Coordinates   1925585..1927777 (+) Length   730 a.a.
NCBI ID   WP_014570077.1    Uniprot ID   A0A809N5K4
Organism   Lacticaseibacillus rhamnosus strain 4B15     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1920585..1932777
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CCE29_RS15885 - 1921298..1921552 (+) 255 WP_162467050.1 hypothetical protein -
  CCE29_RS16010 (CCE29_10130) - 1922010..1922195 (-) 186 WP_076638842.1 bacteriocin -
  CCE29_RS10205 (CCE29_10135) - 1922932..1923720 (-) 789 WP_014570079.1 response regulator transcription factor -
  CCE29_RS10210 (CCE29_10140) - 1923713..1925026 (-) 1314 WP_014570078.1 GHKL domain-containing protein -
  CCE29_RS10215 (CCE29_10145) - 1925202..1925336 (+) 135 WP_005692249.1 bacteriocin-like peptide, LSEI_2386 family -
  CCE29_RS10220 (CCE29_10150) comA 1925585..1927777 (+) 2193 WP_014570077.1 peptide cleavage/export ABC transporter Regulator
  CCE29_RS10225 (CCE29_10155) - 1927790..1929169 (+) 1380 WP_014570076.1 bacteriocin secretion accessory protein -
  CCE29_RS10230 (CCE29_10160) - 1929230..1929640 (+) 411 WP_005692253.1 hypothetical protein -
  CCE29_RS10235 (CCE29_10165) - 1929817..1931172 (+) 1356 WP_005711099.1 threonine/serine ThrE exporter family protein -
  CCE29_RS10245 (CCE29_10175) - 1931475..1932557 (-) 1083 WP_048653151.1 aldo/keto reductase -

Sequence

Protein


Download         Length: 730 a.a.        Molecular weight: 81570.85 Da        Isoelectric Point: 7.2813

>NTDB_id=230617 CCE29_RS10220 WP_014570077.1 1925585..1927777(+) (comA) [Lacticaseibacillus rhamnosus strain 4B15]
MFKHTPKLGQITYYKRFYTAQVDERDCGVAALNMLLKYNGSDYSLAHLRELAKTNQDGTTALGIVRAAEALAFETKPVQA
NMQLFDLEDVPYPFIAHVLKRGELLHYYVVFKATRTSILIGDPDPSVRMTWLSREVFEKEWSGVAIFIAPAPQYQPRKED
KGSLFAFVPMLAKQKGIIANIILAAVLITVISIVGSYFLQSIIDTYIPNAMRTTMGMIASGLLVAYLLQAVLTYGQNFLM
AVLGQRLAIDVILGYVRHLYELPMSFFSTRRTGEIVSRFADANKIIDALANTIMTLFLDVWIVLILGIVLGIQNGTLFLV
SLIAVPCYLVIVFAFQRPFDRLNQETMESNAILSSSIIEDLNGIETIKSLTGERVSYERVDREFLTYLKRSFSYTKADQL
QQAIKGLLKLALNVVVLWIGASLVIANRMSLGQMLTFNALLSYFTNPLESIINLQPKLQMARVANNRLNEVYLVESEFKE
PRHLTERHLIEGPLRVRDVSFKYGFGQDVLKNINLEVPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTDKGTITFNGIPV
KDINLTTLRQYIEYVPQDPFIFSGTVLENLTLGSRSDVSEQDLTQACLAAEIAADIANLPQQWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGKIVEQGDHATLLAQ
DGYYARLVHE

Nucleotide


Download         Length: 2193 bp        

>NTDB_id=230617 CCE29_RS10220 WP_014570077.1 1925585..1927777(+) (comA) [Lacticaseibacillus rhamnosus strain 4B15]
ATGTTTAAACACACCCCCAAACTAGGCCAGATCACCTACTACAAACGCTTCTACACCGCACAAGTTGACGAGCGTGACTG
TGGTGTGGCTGCGTTAAACATGCTGCTTAAATACAATGGGTCGGACTATTCGTTAGCCCACTTGCGCGAGTTAGCGAAGA
CAAATCAGGATGGCACGACGGCTTTGGGAATTGTTCGGGCCGCTGAAGCACTAGCGTTTGAGACGAAACCGGTGCAGGCG
AATATGCAGTTGTTTGATCTTGAGGATGTGCCTTATCCGTTTATTGCCCATGTGCTGAAGCGCGGTGAATTGCTTCATTA
CTATGTTGTTTTTAAAGCAACGCGCACGAGTATTCTGATTGGCGATCCTGACCCGTCAGTGCGCATGACCTGGCTTTCGC
GAGAGGTGTTTGAAAAAGAATGGTCGGGTGTGGCCATCTTTATTGCACCGGCGCCGCAGTATCAGCCGCGTAAGGAGGAC
AAAGGCAGTTTGTTTGCGTTTGTACCCATGCTGGCTAAGCAAAAAGGTATTATCGCGAACATTATTCTGGCCGCGGTATT
GATTACGGTCATTAGTATCGTTGGGTCGTATTTTTTGCAGTCTATTATTGATACGTATATACCGAATGCCATGCGGACGA
CGATGGGGATGATTGCTAGTGGCCTTTTGGTGGCTTACTTGCTGCAAGCTGTGTTGACTTATGGCCAGAATTTTTTGATG
GCGGTGTTGGGGCAGCGGCTTGCGATTGATGTCATTTTAGGGTATGTGCGCCATTTATATGAATTGCCGATGTCGTTTTT
TTCAACTCGGCGGACCGGAGAGATTGTGTCGCGGTTTGCGGATGCCAATAAAATTATTGATGCGCTGGCGAATACGATTA
TGACGTTGTTTTTGGATGTCTGGATTGTCCTAATATTAGGCATTGTTCTAGGGATCCAAAATGGGACTTTGTTTTTAGTG
TCATTGATTGCCGTGCCGTGTTACTTGGTGATTGTTTTTGCATTTCAGCGGCCGTTTGATCGGTTGAATCAAGAGACGAT
GGAAAGTAATGCAATCTTGAGTTCATCGATTATTGAAGATTTGAATGGCATTGAAACCATCAAGTCCTTGACCGGCGAAC
GAGTTAGCTATGAACGGGTTGATCGGGAATTTCTAACCTATTTGAAGAGGTCGTTTAGTTACACCAAGGCAGATCAGTTA
CAGCAAGCGATTAAAGGCCTGTTGAAGCTGGCGTTGAACGTTGTGGTGTTGTGGATTGGGGCAAGTTTGGTGATTGCCAA
TCGAATGAGTTTGGGGCAGATGCTGACCTTTAATGCGCTGCTGTCATACTTTACGAATCCGCTTGAAAGCATCATCAACC
TACAGCCAAAGTTACAAATGGCGCGGGTTGCTAACAATCGTTTGAATGAGGTTTATCTGGTTGAATCGGAATTCAAAGAA
CCGCGGCACTTGACGGAGCGGCATTTAATCGAAGGTCCGTTACGTGTTCGGGATGTTTCGTTTAAATATGGTTTTGGCCA
AGATGTGTTGAAAAACATCAACCTTGAAGTGCCGGAAAATGCTAAATATACCATTGTTGGCATGAGTGGTTCTGGTAAGT
CGACATTAGCAAAATTATTAGTTGGCTTTTACCCAGTTGATACCGATAAGGGAACCATCACGTTTAATGGCATTCCGGTC
AAAGACATTAATCTCACAACATTACGGCAATATATTGAATATGTACCTCAGGATCCATTTATTTTTTCGGGCACGGTGTT
GGAGAATTTGACGTTAGGTAGCCGTTCGGATGTTTCGGAACAAGACTTGACGCAGGCGTGTTTGGCTGCGGAAATTGCCG
CAGACATCGCAAACTTACCGCAGCAGTGGCAGACCAAATTGTCAGAAAGCGGCAGCATTTTATCAGGCGGTCAGAAGCAG
CGGCTGGCGATTGCACGGGCCTTGTTATCGCCGGCAAAAGTACTGATTTTTGACGAATCGACTAGCAGTCTGGATACCAT
TACAGAGCGAAAAATTGTCGATCGCTTGCTGGCAATGACGGATCGGACCATTATTTTTGTTGCCCATCGCTTAACTATTG
CGGCTAAAACCGAACAAATTGTGGTGATGGATCATGGCAAAATTGTGGAACAAGGTGACCATGCAACGTTGTTAGCCCAA
GACGGTTATTACGCGCGCCTGGTTCATGAGTGA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(510-662)

ABC transporter transmembrane region (ABC_membrane)

(180-448)

Peptidase C39 family (Peptidase_C39)

(18-152)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A809N5K4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae D39

58.182

97.945

0.57
  comA Streptococcus pneumoniae R6

58.182

97.945

0.57
  comA Streptococcus pneumoniae Rx1

58.182

97.945

0.57
  comA Streptococcus pneumoniae TIGR4

57.762

97.945

0.566
  comA Streptococcus mitis NCTC 12261

57.762

97.945

0.566
  comA Streptococcus mitis SK321

57.622

97.945

0.564
  comA Streptococcus gordonii str. Challis substr. CH1

56.467

98.493

0.556
  comA/nlmT Streptococcus mutans UA159

53.547

98.493

0.527

Multiple sequence alignment