Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   A6J87_RS04795 Genome accession   NZ_CP020451
Coordinates   955033..956268 (-) Length   411 a.a.
NCBI ID   WP_070577144.1    Uniprot ID   -
Organism   Streptococcus salivarius strain FDAARGOS_259     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 908383..954967 955033..956268 flank 66


Gene organization within MGE regions


Location: 908383..956268
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J87_RS04520 (A6J87_04500) - 908383..909654 (-) 1272 WP_080611628.1 hypothetical protein -
  A6J87_RS04525 (A6J87_10780) - 909684..910892 (-) 1209 WP_192573913.1 SIR2 family protein -
  A6J87_RS04530 (A6J87_04515) purK 910885..911976 (-) 1092 WP_070575663.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  A6J87_RS04535 (A6J87_04520) purE 911963..912454 (-) 492 WP_070575661.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  A6J87_RS04540 (A6J87_04525) purD 912657..913919 (-) 1263 WP_070575659.1 phosphoribosylamine--glycine ligase -
  A6J87_RS04545 (A6J87_04530) - 914226..915065 (+) 840 WP_070575657.1 CHAP domain-containing protein -
  A6J87_RS04550 (A6J87_04535) purH 915257..916804 (-) 1548 WP_070575654.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  A6J87_RS04555 (A6J87_04540) purN 916880..917434 (-) 555 WP_070575652.1 phosphoribosylglycinamide formyltransferase -
  A6J87_RS04560 (A6J87_04545) purM 917434..918456 (-) 1023 WP_070575649.1 phosphoribosylformylglycinamidine cyclo-ligase -
  A6J87_RS04565 (A6J87_04550) purF 918667..920106 (-) 1440 WP_002889568.1 amidophosphoribosyltransferase -
  A6J87_RS04570 (A6J87_04555) - 920262..923987 (-) 3726 WP_070575645.1 phosphoribosylformylglycinamidine synthase -
  A6J87_RS04575 (A6J87_04560) purC 924054..924761 (-) 708 WP_070575642.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  A6J87_RS04580 (A6J87_04565) - 925024..925269 (-) 246 WP_070575639.1 phosphopantetheine-binding protein -
  A6J87_RS04585 (A6J87_04570) plsX 925269..926273 (-) 1005 WP_013989885.1 phosphate acyltransferase PlsX -
  A6J87_RS04590 (A6J87_04575) recO 926485..927258 (-) 774 WP_080611633.1 DNA repair protein RecO -
  A6J87_RS04595 (A6J87_04580) - 927245..928420 (-) 1176 WP_070575634.1 pyridoxal phosphate-dependent aminotransferase -
  A6J87_RS04600 (A6J87_04585) - 928512..929477 (-) 966 WP_070575631.1 ribose-phosphate diphosphokinase -
  A6J87_RS04605 (A6J87_04590) - 929690..931201 (-) 1512 WP_070575628.1 CHAP domain-containing protein -
  A6J87_RS04610 (A6J87_04595) mreD 931286..931810 (-) 525 WP_037599472.1 rod shape-determining protein MreD -
  A6J87_RS04615 (A6J87_04600) mreC 931812..932642 (-) 831 WP_049545166.1 rod shape-determining protein MreC -
  A6J87_RS04725 (A6J87_04710) ftsH 939472..941451 (-) 1980 WP_070577155.1 ATP-dependent zinc metalloprotease FtsH -
  A6J87_RS04730 (A6J87_04715) hpt 941471..942013 (-) 543 WP_060972955.1 hypoxanthine phosphoribosyltransferase -
  A6J87_RS04735 (A6J87_04720) tilS 942095..943360 (-) 1266 WP_080611635.1 tRNA lysidine(34) synthetase TilS -
  A6J87_RS04740 (A6J87_04725) - 943360..944652 (-) 1293 WP_080611636.1 serine hydrolase -
  A6J87_RS04745 (A6J87_04730) - 944658..944780 (-) 123 WP_080611638.1 SP_0009 family protein -
  A6J87_RS04750 (A6J87_04735) - 944780..945151 (-) 372 WP_002886276.1 septum formation initiator family protein -
  A6J87_RS04755 (A6J87_04740) - 945135..945410 (-) 276 WP_002883975.1 RNA-binding S4 domain-containing protein -
  A6J87_RS04760 (A6J87_04745) mfd 945597..949103 (-) 3507 WP_080611640.1 transcription-repair coupling factor -
  A6J87_RS04765 (A6J87_04750) pth 949096..949665 (-) 570 WP_013989873.1 aminoacyl-tRNA hydrolase -
  A6J87_RS04770 (A6J87_04755) ychF 949738..950853 (-) 1116 WP_002883967.1 redox-regulated ATPase YchF -
  A6J87_RS04775 (A6J87_04760) - 951063..951254 (-) 192 WP_002883961.1 DUF951 domain-containing protein -
  A6J87_RS04780 (A6J87_04765) dnaN 951306..952442 (-) 1137 WP_105257715.1 DNA polymerase III subunit beta -
  A6J87_RS04785 (A6J87_04770) dnaA 952597..953961 (-) 1365 WP_037599382.1 chromosomal replication initiator protein DnaA -
  A6J87_RS04790 (A6J87_04775) spo0J 954200..954967 (-) 768 WP_037598566.1 ParB/RepB/Spo0J family partition protein Regulator
  A6J87_RS04795 (A6J87_04780) htrA 955033..956268 (-) 1236 WP_070577144.1 S1C family serine protease Regulator

Sequence

Protein


Download         Length: 411 a.a.        Molecular weight: 42958.16 Da        Isoelectric Point: 4.6739

>NTDB_id=223248 A6J87_RS04795 WP_070577144.1 955033..956268(-) (htrA) [Streptococcus salivarius strain FDAARGOS_259]
MKKFNWKKIVAPIAMLVIGLLGGLLGAFILLTAAGVSFTNTTDTGVKTAKTVYNNTTDTTKAVKKVQNAVVSVINYQEGS
SSDSLNELYGRIFGGDDSSDSSQDKSKDSDGLQVAGEGSGVIYKKDGKEAYIVTNNHVVDGAKKLEIMLSDGSKITGELV
GKDTYSDLAVVKVSSDKIKTVAEFADSNSLTVGEKAIAIGSPLGTEYANSVTEGIVSSLSRTVTMQNDNGETVSTNAIQT
DAAINPGNSGGALVNIEGQVIGINSSKISSTSAVAGSAVEGMGFAIPSNDVVEIINQLEKDGKVTRPALGISMADLNSLS
SSATSKLDLPDEVKSGVVVGSVQKGMPADGKLQENDVITQIDGKEISSKTDIQTNLYSHSIGDTIKVTFYRGKEKKTEEL
KLTKSTEDLSD

Nucleotide


Download         Length: 1236 bp        

>NTDB_id=223248 A6J87_RS04795 WP_070577144.1 955033..956268(-) (htrA) [Streptococcus salivarius strain FDAARGOS_259]
GTGAAAAAATTTAACTGGAAAAAAATAGTAGCGCCAATTGCAATGCTTGTTATTGGCTTACTAGGTGGTCTACTAGGTGC
CTTTATCCTATTAACAGCAGCAGGGGTATCTTTTACCAATACAACAGATACAGGTGTTAAAACAGCTAAGACCGTATATA
ACAATACAACAGATACAACTAAGGCCGTTAAGAAAGTACAAAATGCCGTTGTTTCTGTCATCAATTACCAAGAAGGCTCA
TCTTCAGATTCCCTAAATGAACTTTATGGTCGTATTTTTGGTGGAGATGATAGTTCTGATTCTAGCCAAGACAAATCAAA
AGATTCTGATGGATTGCAAGTCGCTGGTGAAGGTTCCGGTGTTATCTATAAAAAAGATGGGAAAGAGGCCTACATCGTAA
CCAACAACCACGTTGTTGATGGTGCTAAAAAACTTGAAATCATGCTTTCAGATGGATCAAAAATTACTGGTGAACTCGTT
GGTAAAGATACTTACTCTGACCTAGCAGTTGTCAAAGTTTCTTCAGATAAAATAAAAACCGTCGCAGAATTTGCAGATTC
AAACTCCCTCACAGTTGGTGAAAAGGCAATTGCTATCGGTAGCCCACTTGGTACCGAATACGCCAACTCAGTAACAGAGG
GAATCGTATCTAGCCTTAGCCGTACCGTAACTATGCAAAACGACAATGGTGAAACTGTCTCAACAAATGCTATCCAAACA
GATGCTGCCATTAACCCTGGTAACTCTGGTGGTGCCTTAGTCAATATTGAAGGACAAGTTATCGGTATTAATTCAAGTAA
GATTTCATCAACGTCAGCAGTCGCTGGTAGTGCCGTTGAAGGTATGGGATTCGCCATTCCATCAAACGATGTTGTCGAAA
TCATTAATCAATTGGAAAAAGACGGTAAAGTTACACGCCCAGCCCTAGGAATCTCAATGGCCGATCTTAATAGCCTTTCT
AGCAGTGCAACTTCTAAATTAGATTTACCAGATGAAGTTAAATCTGGAGTTGTTGTCGGTAGCGTTCAAAAAGGTATGCC
AGCTGACGGTAAACTTCAAGAAAATGATGTTATTACTCAAATTGACGGTAAGGAAATCAGCTCAAAAACTGATATTCAAA
CCAATCTTTACAGCCATAGTATCGGAGATACAATCAAGGTAACCTTCTATCGTGGTAAAGAGAAGAAAACTGAAGAACTT
AAATTAACAAAATCTACAGAAGACTTATCTGACTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(4-406)

Trypsin-like peptidase domain (Trypsin_2)

(118-263)

PDZ domain (PDZ_2)

(307-402)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

61.538

98.054

0.603
  htrA Streptococcus gordonii str. Challis substr. CH1

57.524

100

0.577
  htrA Streptococcus mitis NCTC 12261

54.768

99.513

0.545
  htrA Streptococcus pneumoniae TIGR4

54.523

99.513

0.543
  htrA Streptococcus pneumoniae D39

54.523

99.513

0.543
  htrA Streptococcus pneumoniae Rx1

54.523

99.513

0.543
  htrA Streptococcus pneumoniae R6

54.523

99.513

0.543

Multiple sequence alignment