Detailed information NTG0223224

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: A6J87_RS02135
• Genome accession: NZ_CP020451
• Coordinates: 428316..429059 (+)
• Length: 247 a.a.
• NCBI ID: WP_002887222.1
• Uniprot ID: A0A074IYC3
• Organism: Streptococcus salivarius strain FDAARGOS_259
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 423316..434059

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J87_RS02105 (A6J87_02085)	-	423363..424916 (-)	1554	WP_013990980.1	BCCT family transporter	-
A6J87_RS02110 (A6J87_02095)	-	425144..425755 (-)	612	WP_037602032.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
A6J87_RS02115 (A6J87_02100)	-	425783..425998 (-)	216	Protein_415	CHAP domain-containing protein	-
A6J87_RS02120 (A6J87_02105)	tnpA	426372..426845 (-)	474	WP_002891962.1	IS200/IS605 family transposase	-
A6J87_RS10950	-	427112..427369 (-)	258	Protein_417	type II toxin-antitoxin system Phd/YefM family antitoxin	-
A6J87_RS02135 (A6J87_02120)	comE/blpR	428316..429059 (+)	744	WP_002887222.1	response regulator transcription factor	Regulator
A6J87_RS02140 (A6J87_02125)	-	429069..430376 (+)	1308	WP_037602025.1	sensor histidine kinase	-
A6J87_RS02145 (A6J87_02130)	-	430616..431182 (-)	567	WP_080611511.1	transcriptional regulator	-
A6J87_RS02155 (A6J87_02140)	-	431586..431876 (+)	291	WP_037602021.1	hypothetical protein	-
A6J87_RS02160 (A6J87_02145)	rplL	431979..432347 (-)	369	WP_004183006.1	50S ribosomal protein L7/L12	-
A6J87_RS02165 (A6J87_02150)	rplJ	432422..432925 (-)	504	WP_004183007.1	50S ribosomal protein L10	-

Sequence

Protein

• Length: 247 a.a.
• Molecular weight: 28700.12 Da
• Isoelectric Point: 6.2541

>NTDB_id=223224 A6J87_RS02135 WP_002887222.1 428316..429059(+) (comE/blpR) [Streptococcus salivarius strain FDAARGOS_259]
MLNIFILEDEFLQQTRIETVIKDVIAKKSLKCKGPEIFGKPSQLLDAITERGSHQLFFLDIEIKGEEKKGLDIAKEIRKK
DPNATIVFVTTHSEFMPVTFKYRVAALDFIDKALDDEDFYERVHLAIEYTMNKMGATIAQDSFTFETATAQVQVPFNNIL
FFETSPTIHKVILHTKEERMEFYASISEVERADDRLYRCHRSFIVNPENIVKINKEEKMVMFENNNECPISRTKYKGLLE
KVKSLKS

Nucleotide

• Length: 744 bp

>NTDB_id=223224 A6J87_RS02135 WP_002887222.1 428316..429059(+) (comE/blpR) [Streptococcus salivarius strain FDAARGOS_259]
TTGTTAAATATTTTTATTTTAGAAGACGAATTTTTACAACAAACACGAATAGAGACCGTTATTAAGGATGTTATTGCAAA
AAAATCTCTAAAATGTAAAGGACCTGAGATTTTTGGAAAACCTAGCCAGCTACTTGATGCGATTACCGAAAGAGGTTCTC
ATCAACTTTTCTTTTTAGATATTGAAATTAAAGGAGAAGAAAAAAAGGGGCTAGACATTGCGAAAGAAATTCGGAAAAAA
GACCCTAATGCAACAATTGTTTTTGTAACAACACATTCAGAATTTATGCCAGTCACTTTTAAATATAGAGTTGCTGCACT
AGATTTTATCGATAAAGCTTTGGATGATGAAGATTTTTATGAACGTGTTCATTTAGCAATTGAATATACCATGAATAAAA
TGGGTGCTACTATTGCCCAAGATTCATTTACTTTTGAAACAGCTACGGCTCAAGTTCAAGTTCCTTTTAACAATATCTTA
TTTTTTGAAACGTCTCCAACAATACATAAAGTTATTTTGCATACTAAAGAAGAACGAATGGAGTTCTACGCCAGTATTTC
AGAAGTTGAACGAGCTGACGACCGCCTATATCGATGCCATCGTTCATTTATCGTTAATCCTGAAAATATCGTTAAGATCA
ATAAAGAAGAGAAAATGGTAATGTTTGAAAATAATAATGAATGTCCCATTTCCCGTACGAAATATAAGGGCCTCCTAGAA
AAAGTTAAATCTCTGAAAAGCTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-241)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A074IYC3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.975	96.761	0.522
comE/comE1	Streptococcus equinus JB1	45.679	98.381	0.449
comE/comE2	Streptococcus equinus JB1	39.431	99.595	0.393
comE/comE2	Streptococcus gordonii strain NCTC7865	37.652	100	0.377
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.652	100	0.377