Detailed information NTG0220400

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: B4W66_RS00260
• Genome accession: NZ_CP020027
• Coordinates: 47483..48394 (+)
• Length: 303 a.a.
• NCBI ID: WP_020904818.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain STAB090229
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42483..53394

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B4W66_RS00240 (B4W66_00240)	purE	42767..43258 (+)	492	WP_002986689.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
B4W66_RS00245 (B4W66_00245)	purK	43245..44318 (+)	1074	WP_164997029.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
B4W66_RS00250 (B4W66_00250)	-	44345..46042 (+)	1698	WP_020904816.1	AIPR family protein	-
B4W66_RS00255 (B4W66_00255)	purB	46060..47352 (+)	1293	WP_020904817.1	adenylosuccinate lyase	-
B4W66_RS00260 (B4W66_00260)	comR	47483..48394 (+)	912	WP_020904818.1	helix-turn-helix domain-containing protein	Regulator
B4W66_RS09620	comS	48485..48583 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
B4W66_RS00265 (B4W66_00265)	ruvB	48614..49612 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
B4W66_RS00270 (B4W66_00270)	-	49750..50187 (+)	438	WP_020904819.1	low molecular weight protein-tyrosine-phosphatase	-
B4W66_RS00275 (B4W66_00275)	-	50211..50612 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
B4W66_RS00280 (B4W66_00280)	-	50609..52384 (+)	1776	WP_076639715.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35887.54 Da
• Isoelectric Point: 4.9349

>NTDB_id=220400 B4W66_RS00260 WP_020904818.1 47483..48394(+) (comR) [Streptococcus pyogenes strain STAB090229]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=220400 B4W66_RS00260 WP_020904818.1 47483..48394(+) (comR) [Streptococcus pyogenes strain STAB090229]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAGGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366