Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   B2J85_RS10000 Genome accession   NZ_CP020017
Coordinates   2078840..2080108 (+) Length   422 a.a.
NCBI ID   WP_061840691.1    Uniprot ID   A0A2H6CVH6
Organism   Tetragenococcus halophilus strain KUD23     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2073840..2085108
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  B2J85_RS09980 - 2074107..2076233 (-) 2127 WP_094244013.1 BglG family transcription antiterminator -
  B2J85_RS09985 msrA 2076400..2077221 (-) 822 WP_094244014.1 peptide-methionine (S)-S-oxide reductase MsrA -
  B2J85_RS09990 - 2077448..2077975 (-) 528 WP_094244015.1 hypothetical protein -
  B2J85_RS09995 rlmH 2078019..2078498 (-) 480 WP_014123651.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  B2J85_RS10000 htrA 2078840..2080108 (+) 1269 WP_061840691.1 S1C family serine protease Regulator
  B2J85_RS10005 ytpR 2080152..2080763 (-) 612 WP_094244016.1 YtpR family tRNA-binding protein -
  B2J85_RS10010 - 2080816..2081274 (-) 459 WP_014123648.1 universal stress protein -
  B2J85_RS10015 - 2081297..2081611 (-) 315 WP_014123647.1 thioredoxin family protein -
  B2J85_RS10020 pepA 2081699..2082775 (-) 1077 WP_014123646.1 glutamyl aminopeptidase -
  B2J85_RS10025 - 2082919..2083770 (+) 852 WP_094244017.1 aminoglycoside 6-adenylyltransferase -
  B2J85_RS10030 - 2083847..2084188 (+) 342 WP_014123644.1 PepSY domain-containing protein -

Sequence

Protein


Download         Length: 422 a.a.        Molecular weight: 43973.74 Da        Isoelectric Point: 3.7200

>NTDB_id=220139 B2J85_RS10000 WP_061840691.1 2078840..2080108(+) (htrA) [Tetragenococcus halophilus strain KUD23]
MAKKNVTPDSKKGGWIKKFGIGLLGGLIGGLLVIGGFYYFSNGNPFQTNEATSSSGVTDNNDDVQVSDVKVDADSDTTDA
VENVQNAVVSVINLQNSSPQESGGIFGTEQPEGNSEDDEEPAGEGSGVIYKEDGGDAYIVTNNHVVAGQSGLEVVMADGS
REQAELVGTDAYTDLAVLKISSDNVDTVATFGDSDELQVGEPAIAIGSPLGSDYANSVTQGIISSVNRLVSSQNESGEDV
STNAIQTDAAINPGNSGGPLVNAGGQVVGINSSKIASSGQAGVSVEGMGFAIPSNDVTDIINELEENGEIARPALGISML
DLNTIPTEQRQRVLQIPEDVENGVVVENPGDGTPASDAGLEQYDVITKVDDKEIKDSTELRAALYEKSVGDTLKLTFYRQ
DDAQSVNVKLSEDQSIIESNNE

Nucleotide


Download         Length: 1269 bp        

>NTDB_id=220139 B2J85_RS10000 WP_061840691.1 2078840..2080108(+) (htrA) [Tetragenococcus halophilus strain KUD23]
ATGGCAAAAAAGAATGTAACACCTGATTCTAAAAAAGGCGGGTGGATTAAAAAATTCGGAATTGGCCTATTAGGTGGATT
AATAGGCGGGTTACTTGTCATTGGTGGCTTTTATTATTTTTCTAATGGTAACCCATTTCAAACAAATGAAGCAACTTCTT
CATCTGGCGTAACAGATAATAACGACGACGTACAGGTCAGTGATGTTAAAGTTGATGCCGATAGTGATACCACAGACGCT
GTAGAAAATGTACAAAATGCTGTCGTTTCAGTGATCAATTTACAAAACTCTTCTCCTCAAGAAAGCGGAGGTATTTTTGG
CACCGAGCAACCAGAAGGCAACTCTGAAGACGACGAGGAGCCAGCTGGTGAAGGTAGTGGTGTGATTTACAAAGAAGATG
GCGGCGATGCCTACATTGTAACAAATAATCACGTAGTTGCCGGACAAAGTGGCTTAGAAGTAGTTATGGCAGACGGTAGT
AGAGAACAAGCAGAATTAGTAGGTACTGATGCTTATACTGACTTAGCCGTATTAAAAATTTCTTCTGATAATGTAGACAC
AGTAGCTACATTCGGTGATTCTGATGAATTACAAGTAGGTGAACCAGCGATCGCTATTGGTTCTCCTCTAGGTTCTGATT
ATGCTAATTCAGTAACCCAAGGAATTATTTCTTCAGTCAATCGTTTAGTATCCAGCCAAAATGAATCTGGCGAAGATGTG
AGCACAAATGCTATTCAAACGGACGCTGCAATCAACCCAGGAAATTCTGGCGGGCCATTGGTCAATGCTGGTGGACAAGT
TGTTGGAATTAACTCCAGTAAAATTGCTAGTTCCGGACAAGCTGGCGTAAGTGTTGAAGGCATGGGCTTTGCTATTCCAA
GTAATGATGTAACAGATATTATTAATGAATTGGAAGAAAATGGTGAAATTGCTCGTCCAGCGTTAGGCATCTCCATGCTT
GATTTAAATACCATTCCTACAGAACAAAGACAACGTGTTTTACAAATCCCTGAGGATGTAGAAAACGGCGTTGTTGTAGA
AAACCCTGGCGATGGCACACCAGCAAGTGATGCAGGATTAGAACAATATGATGTTATTACAAAAGTTGACGATAAAGAAA
TAAAAGATTCTACTGAGCTACGTGCCGCTTTATATGAAAAATCAGTAGGAGATACTTTGAAATTGACTTTTTATCGACAA
GATGACGCACAATCTGTAAATGTTAAACTATCAGAAGATCAATCAATCATTGAAAGCAACAACGAATAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(313-410)

Trypsin-like peptidase domain (Trypsin_2)

(125-270)

Peptidase family M50 (Peptidase_M50)

(317-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2H6CVH6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

58.38

84.834

0.495
  htrA Streptococcus mitis NCTC 12261

50.256

92.417

0.464
  htrA Streptococcus gordonii str. Challis substr. CH1

49.745

92.891

0.462
  htrA Streptococcus pneumoniae TIGR4

49.744

92.417

0.46
  htrA Streptococcus pneumoniae D39

49.744

92.417

0.46
  htrA Streptococcus pneumoniae Rx1

49.744

92.417

0.46
  htrA Streptococcus pneumoniae R6

49.744

92.417

0.46

Multiple sequence alignment