Detailed information NTG0021929

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: SPYM18_RS02345
• Genome accession: NC_003485
• Coordinates: 432074..434227 (-)
• Length: 717 a.a.
• NCBI ID: WP_011017463.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes MGAS8232
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 427074..439227

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYM18_RS02330 (spyM18_0538)	comE/blpR	428266..429015 (+)	750	WP_002992578.1	response regulator transcription factor	Regulator
SPYM18_RS02335 (spyM18_0539)	-	429016..430350 (+)	1335	WP_011017461.1	sensor histidine kinase	-
SPYM18_RS09785 (spyM18_0540)	-	430498..430623 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SPYM18_RS02340	-	430700..432063 (-)	1364	Protein_420	bacteriocin secretion accessory protein	-
SPYM18_RS02345 (spyM18_0543)	comA/nlmT	432074..434227 (-)	2154	WP_011017463.1	peptide cleavage/export ABC transporter	Regulator
SPYM18_RS02350 (spyM18_0544)	-	434514..434741 (+)	228	WP_002992018.1	Blp family class II bacteriocin	-
SPYM18_RS02355 (spyM18_0545)	-	434754..434954 (+)	201	WP_002985729.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SPYM18_RS10615 (spyM18_0547)	-	435315..435443 (+)	129	WP_002985724.1	hypothetical protein	-
SPYM18_RS10660	-	435493..435788 (+)	296	Protein_425	hypothetical protein	-
SPYM18_RS02370	-	435967..436401 (+)	435	WP_032465693.1	hypothetical protein	-
SPYM18_RS02375 (spyM18_0548)	-	436619..437689 (+)	1071	WP_032465692.1	hypothetical protein	-
SPYM18_RS02380 (spyM18_0549)	-	437782..438180 (+)	399	WP_009880375.1	hypothetical protein	-
SPYM18_RS02385 (spyM18_0550)	stcA	438529..438798 (-)	270	WP_011017467.1	quorum-sensing system protein StcA	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80558.46 Da
• Isoelectric Point: 6.8704

>NTDB_id=21929 SPYM18_RS02345 WP_011017463.1 432074..434227(-) (comA/nlmT) [Streptococcus pyogenes MGAS8232]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLINFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVSISGSGITTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=21929 SPYM18_RS02345 WP_011017463.1 432074..434227(-) (comA/nlmT) [Streptococcus pyogenes MGAS8232]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGGTTTGAAACAAGAGCTATTCAAGCAGACATGACCCTTTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAACTTTTTACCTCTT
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAATTACCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACCAAACTTCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAATTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTAGTATTAGTGGATCTGGTATAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.727	99.721	0.725
comA	Streptococcus mitis NCTC 12261	67.37	99.163	0.668
comA	Streptococcus mitis SK321	66.948	99.163	0.664
comA	Streptococcus pneumoniae Rx1	66.948	99.163	0.664
comA	Streptococcus pneumoniae D39	66.948	99.163	0.664
comA	Streptococcus pneumoniae R6	66.948	99.163	0.664
comA	Streptococcus pneumoniae TIGR4	66.667	99.163	0.661
comA	Streptococcus gordonii str. Challis substr. CH1	65.874	99.721	0.657