Detailed information NTG0218100

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: CXP41_RS16510
• Genome accession: NZ_CP025268
• Coordinates: 3172132..3172791 (+)
• Length: 219 a.a.
• NCBI ID: WP_001221495.1
• Uniprot ID: P52076
• Organism: Escherichia coli str. K-12 substr. MG1655 strain K-12
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 3167132..3177791

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CXP41_RS16480 (CXP41_16480)	ygiS	3168415..3170022 (-)	1608	WP_001295629.1	ABC transporter substrate-binding protein	-
CXP41_RS16490 (CXP41_16490)	mqsA	3170155..3170550 (-)	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	-
CXP41_RS16495 (CXP41_16495)	mqsR	3170552..3170848 (-)	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	-
CXP41_RS16500 (CXP41_16500)	ygiV	3171053..3171535 (-)	483	WP_000183505.1	GyrI-like domain-containing protein	-
CXP41_RS16505 (CXP41_16505)	ygiW	3171588..3171980 (-)	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
CXP41_RS16510 (CXP41_16510)	ciaR	3172132..3172791 (+)	660	WP_001221495.1	quorum sensing response regulator transcription factor QseB	Regulator
CXP41_RS16515 (CXP41_16515)	qseC	3172788..3174137 (+)	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
CXP41_RS16520 (CXP41_16520)	ygiZ	3174183..3174515 (-)	333	WP_000917684.1	DUF2645 family protein	-
CXP41_RS16530 (CXP41_16530)	mdaB	3174834..3175415 (+)	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
CXP41_RS16535 (CXP41_16535)	ygiN	3175446..3175760 (+)	315	WP_000958598.1	putative quinol monooxygenase	-
CXP41_RS16540 (CXP41_16540)	parE	3175808..3177700 (-)	1893	WP_000195296.1	DNA topoisomerase IV subunit B	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24677.59 Da
• Isoelectric Point: 6.9850

>NTDB_id=218100 CXP41_RS16510 WP_001221495.1 3172132..3172791(+) (ciaR) [Escherichia coli str. K-12 substr. MG1655 strain K-12]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLSRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide

• Length: 660 bp

>NTDB_id=218100 CXP41_RS16510 WP_001221495.1 3172132..3172791(+) (ciaR) [Escherichia coli str. K-12 substr. MG1655 strain K-12]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGTCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-216)

3D structure

• AlphaFold DB: P52076

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	37.885	100	0.393
ciaR	Streptococcus pneumoniae D39	37.885	100	0.393
ciaR	Streptococcus pneumoniae R6	37.885	100	0.393
ciaR	Streptococcus pneumoniae TIGR4	37.885	100	0.393
ciaR	Streptococcus mutans UA159	35.426	100	0.361