Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   BZG42_RS08195 Genome accession   NZ_CP019557
Coordinates   1732190..1732912 (-) Length   240 a.a.
NCBI ID   WP_024531872.1    Uniprot ID   A0A2Z5TQ77
Organism   Streptococcus sp. DAT741     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1727190..1737912
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BZG42_RS08175 (BZG42_08235) - 1728317..1728859 (-) 543 WP_227984809.1 GNAT family N-acetyltransferase -
  BZG42_RS08180 (BZG42_08240) sufD 1728888..1730150 (-) 1263 WP_155964976.1 Fe-S cluster assembly protein SufD -
  BZG42_RS08185 (BZG42_08245) sufC 1730167..1730940 (-) 774 WP_024531874.1 Fe-S cluster assembly ATPase SufC -
  BZG42_RS08190 (BZG42_08250) - 1731033..1732193 (-) 1161 WP_120172178.1 MraY family glycosyltransferase -
  BZG42_RS08195 (BZG42_08255) mecA 1732190..1732912 (-) 723 WP_024531872.1 adaptor protein MecA Regulator
  BZG42_RS08200 (BZG42_08260) - 1733123..1733959 (-) 837 WP_155972136.1 undecaprenyl-diphosphate phosphatase -
  BZG42_RS08205 (BZG42_08265) - 1734091..1735653 (+) 1563 WP_155995776.1 ABC transporter substrate-binding protein/permease -
  BZG42_RS08210 (BZG42_08270) - 1735646..1736389 (+) 744 WP_024531869.1 amino acid ABC transporter ATP-binding protein -
  BZG42_RS08215 (BZG42_08275) - 1736638..1736847 (-) 210 WP_024531868.1 hypothetical protein -
  BZG42_RS09970 (BZG42_08280) - 1736933..1737832 (-) 900 WP_024531867.1 SPFH domain-containing protein -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 28012.59 Da        Isoelectric Point: 4.1200

>NTDB_id=216234 BZG42_RS08195 WP_024531872.1 1732190..1732912(-) (mecA) [Streptococcus sp. DAT741]
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDL
DQNLNFDEFTDLSDLGDVASMTPDEFFKSLEQTVREKSAADVAAVHHLEDIEQAEEDEDGEQERYIYYILEFKKIEELFI
FVGTVDYSIEESELYKMDGYYYLTVLVDIENRSKQYPEHLLSRMLEFSNDTKLARPVLQEHGMLLLSHAAIEELRKVTIA

Nucleotide


Download         Length: 723 bp        

>NTDB_id=216234 BZG42_RS08195 WP_024531872.1 1732190..1732912(-) (mecA) [Streptococcus sp. DAT741]
ATGAAAGTAAAACAAATTAGTGATTCTACCTTAAAAATCACTATCAAATTGGATGACTTGGAAGAAAGAGGCATGGAACT
TTCTGACTTTCTTATCCCACAGGAGAAGACAGAAGAGTTTTTCTACACAGTTCTGGATGAGCTGGACTTGCCGATGACTT
TCCGCGAAAGTGGTATGCTGAGTTTCCGTGTGACACCAAAGCCTGATAGGGTTGACATTTTTGTGACCAAATCTGATTTG
GATCAAAATTTGAATTTTGATGAATTTACAGATTTGTCTGACCTTGGTGATGTTGCCAGTATGACTCCAGATGAATTTTT
CAAGAGTTTGGAGCAGACGGTTCGTGAGAAGAGTGCCGCAGATGTAGCTGCTGTCCACCATCTAGAAGATATTGAGCAGG
CAGAAGAGGATGAGGACGGAGAGCAAGAACGGTATATCTACTATATTTTAGAGTTCAAAAAGATTGAAGAACTGTTTATT
TTTGTTGGTACGGTTGACTATTCGATTGAAGAATCGGAACTTTATAAGATGGATGGTTACTATTATCTGACAGTTCTTGT
TGATATAGAAAACCGTTCCAAGCAATATCCAGAGCACCTTCTTTCACGTATGTTAGAGTTTTCCAACGATACAAAATTAG
CAAGACCTGTCTTGCAAGAACACGGGATGCTCCTCCTCTCCCATGCAGCGATTGAAGAGCTTAGAAAGGTTACAATAGCA
TGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TQ77

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

55.328

100

0.563
  mecA Streptococcus pneumoniae D39

55.328

100

0.563
  mecA Streptococcus pneumoniae R6

55.328

100

0.563
  mecA Streptococcus pneumoniae TIGR4

55.328

100

0.563
  mecA Streptococcus mutans UA159

50

100

0.508
  mecA Streptococcus thermophilus LMD-9

46.586

100

0.483
  mecA Streptococcus thermophilus LMG 18311

46.185

100

0.479

Multiple sequence alignment