Detailed information NTG0214677

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: BWQ98_RS02415
• Genome accession: NZ_CP019299
• Coordinates: 447101..447838 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae strain HKU1-14
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 442101..452838

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWQ98_RS02385 (BWQ98_02390)	-	443433..443720 (-)	288	WP_000777753.1	hypothetical protein	-
BWQ98_RS02390 (BWQ98_02395)	-	443730..444140 (-)	411	WP_001278322.1	HIT family protein	-
BWQ98_RS02395 (BWQ98_02400)	pptA	444208..444939 (+)	732	WP_000889956.1	ABC transporter ATP-binding protein	Regulator
BWQ98_RS02400 (BWQ98_02405)	-	444936..445985 (+)	1050	WP_127244993.1	ABC transporter permease	-
BWQ98_RS02405 (BWQ98_02410)	-	446153..446482 (-)	330	WP_000132572.1	hypothetical protein	-
BWQ98_RS02410 (BWQ98_02415)	-	446758..447096 (+)	339	WP_050115203.1	LytTR family DNA-binding domain-containing protein	-
BWQ98_RS02415 (BWQ98_02420)	comE/blpR	447101..447838 (+)	738	WP_001219126.1	response regulator transcription factor	Regulator
BWQ98_RS02420 (BWQ98_02425)	-	447852..449192 (+)	1341	WP_127244994.1	sensor histidine kinase	-
BWQ98_RS02425 (BWQ98_02430)	blpC	449236..449391 (-)	156	WP_061450964.1	quorum-sensing system pheromone BlpC	-
BWQ98_RS02430 (BWQ98_02435)	-	449448..450809 (-)	1362	WP_050211505.1	bacteriocin secretion accessory protein	-
BWQ98_RS11765	comA/nlmT	450820..450984 (-)	165	WP_306420852.1	hypothetical protein	Regulator
BWQ98_RS11770 (BWQ98_02440)	blpA	451194..452495 (-)	1302	Protein_455	peptide cleavage/export ABC transporter BlpA	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=214677 BWQ98_RS02415 WP_001219126.1 447101..447838(+) (comE/blpR) [Streptococcus pneumoniae strain HKU1-14]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=214677 BWQ98_RS02415 WP_001219126.1 447101..447838(+) (comE/blpR) [Streptococcus pneumoniae strain HKU1-14]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384