Detailed information NTG0210797

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: BUM80_RS00160
• Genome accession: NZ_CP018838
• Coordinates: 30544..31281 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 11A
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 25544..36281

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BUM80_RS11435 (BUM80_00120)	-	26474..26713 (-)	240	WP_001810235.1	hypothetical protein	-
BUM80_RS00130 (BUM80_00125)	-	26875..27162 (-)	288	WP_000777760.1	hypothetical protein	-
BUM80_RS00135 (BUM80_00130)	-	27172..27582 (-)	411	WP_001278300.1	HIT family protein	-
BUM80_RS00140 (BUM80_00135)	pptA	27650..28381 (+)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
BUM80_RS00145 (BUM80_00140)	-	28378..29427 (+)	1050	WP_000653767.1	ABC transporter permease	-
BUM80_RS00150 (BUM80_00145)	-	29595..29924 (-)	330	WP_000132572.1	hypothetical protein	-
BUM80_RS00155 (BUM80_00150)	-	30201..30539 (+)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
BUM80_RS00160 (BUM80_00155)	comE/blpR	30544..31281 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
BUM80_RS00165 (BUM80_00160)	-	31295..32635 (+)	1341	WP_001017638.1	sensor histidine kinase	-
BUM80_RS00170 (BUM80_00165)	blpC	32677..32832 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
BUM80_RS00175 (BUM80_00170)	-	32889..34250 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
BUM80_RS00180 (BUM80_00175)	comA/nlmT	34261..35937 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=210797 BUM80_RS00160 WP_001219120.1 30544..31281(+) (comE/blpR) [Streptococcus pneumoniae strain 11A]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=210797 BUM80_RS00160 WP_001219120.1 30544..31281(+) (comE/blpR) [Streptococcus pneumoniae strain 11A]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363