Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   L_RS00465 Genome accession   NC_002662
Coordinates   82576..84723 (+) Length   715 a.a.
NCBI ID   WP_010905094.1    Uniprot ID   A0A0V8DTP2
Organism   Lactococcus lactis subsp. lactis Il1403     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 77576..89723
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L_RS00440 (L1010) - 78713..79180 (+) 468 WP_010905090.1 universal stress protein -
  L_RS00445 (L200005) - 79309..79506 (+) 198 WP_010905091.1 DUF4649 domain-containing protein -
  L_RS00450 (L79507) - 79537..80157 (+) 621 WP_010905092.1 alpha/beta hydrolase -
  L_RS00455 (L80191) - 80208..81377 (+) 1170 WP_010905093.1 ring-cleaving dioxygenase -
  L_RS00460 (L81206) - 81388..81978 (+) 591 WP_003132255.1 flavin reductase family protein -
  L_RS00465 (L82520) comA 82576..84723 (+) 2148 WP_010905094.1 peptide cleavage/export ABC transporter Regulator
  L_RS00470 (L84721) - 84738..86159 (+) 1422 WP_010905095.1 HlyD family secretion protein -
  L_RS00475 - 86253..86378 (+) 126 WP_021214955.1 lactococcin family bacteriocin -
  L_RS00480 (L87100) - 87111..87767 (+) 657 WP_010905097.1 CPBP family intramembrane glutamic endopeptidase -
  L_RS00485 (L87874) - 87870..88151 (-) 282 WP_010905098.1 hypothetical protein -
  L_RS00490 (L200006) - 88161..88313 (-) 153 WP_010905099.1 hypothetical protein -
  L_RS00495 - 88977..89102 (+) 126 WP_227028641.1 lactococcin family bacteriocin -

Sequence

Protein


Download         Length: 715 a.a.        Molecular weight: 79865.43 Da        Isoelectric Point: 8.6006

>NTDB_id=20737 L_RS00465 WP_010905094.1 82576..84723(+) (comA) [Lactococcus lactis subsp. lactis Il1403]
MKFKKKNYTSQVDEMDCGCAALSMILKSYGTEKSLASLRLLAGTTIEGTSALGIKKAGEGLGFVVQVLRADASLFEMKKV
PYPFIAHVIKNQKYPHYYVITGANKNSVFIADPDPTVKMTKLSKEVFLSEWTGISLFLSPTPSYQPTKEKTSSLLSFIPI
ITRQKKVILNIVIASFIVTLINILGSYYLQSMIDSYIPNALMGTLGIISVGLLLTYIIQQVLEFAKAFLLNVLSQRLAID
VILSYIRHIFQLPMSFFSTRRTGEITSRFSDASSILDAIASTILSLFLDLTIVLMTGLILGLQNMQLFLLVLLAIPLYIV
VIIIFTPLFERQNHEVMQTNAILNSSIIEDINGIETIKALASEQERYQKIDYEFASYLKEAFTLQQSEAIQTAIKTTVQL
VLNVLILWFGATLVMHQKITLGQLITFNALLSYFTNPITNIINLQTKLQKARVANERLNEVYLVPSEFEEKKTELSLSHF
NLNMSEISYQYGFGRKVLSEIKLSIKENEKLTIVGISGSGKSTLVKLLVNFFQPTSGTITLGGIDLQQFDKHQLRRLINY
LPQQPYIFTGSIMDNLLLGASEATSQEEIIRAVELAEIRADIEQMQLGYQTELSSDASSLSGGQKQRIALARALLSPAKI
LILDEATSNLDMITEKKILKNLLALDKTIIFIAHRLSVAEMSHRIIVIEQGKVIESGSHSELLAQNGFYAQLYHN

Nucleotide


Download         Length: 2148 bp        

>NTDB_id=20737 L_RS00465 WP_010905094.1 82576..84723(+) (comA) [Lactococcus lactis subsp. lactis Il1403]
ATGAAATTTAAAAAGAAAAATTATACCTCCCAAGTAGATGAAATGGATTGTGGATGTGCTGCTTTATCAATGATTTTAAA
ATCCTATGGGACAGAAAAATCGCTTGCCTCTCTTCGTTTACTTGCTGGTACAACAATCGAGGGAACTTCCGCTTTAGGAA
TAAAAAAAGCAGGAGAAGGTTTAGGTTTTGTAGTTCAAGTACTAAGAGCTGATGCAAGCCTTTTTGAAATGAAGAAAGTC
CCTTACCCTTTTATTGCTCATGTCATCAAGAACCAAAAGTATCCACACTACTATGTGATAACTGGCGCAAATAAAAATTC
GGTATTCATCGCAGATCCTGACCCAACCGTTAAAATGACAAAACTTTCAAAAGAAGTTTTCTTATCAGAGTGGACAGGCA
TTAGCTTATTTCTTTCACCTACCCCATCCTATCAGCCCACTAAAGAAAAAACTTCTTCATTATTATCTTTTATCCCAATT
ATCACCCGTCAAAAGAAAGTCATTCTCAATATTGTAATTGCCTCATTCATTGTAACGTTGATTAATATTCTAGGGTCTTA
CTACCTCCAGAGCATGATTGATAGTTACATTCCAAATGCCTTAATGGGAACTTTAGGGATTATCTCAGTAGGGCTATTGT
TAACTTATATTATCCAACAAGTCTTAGAGTTTGCTAAGGCTTTCTTACTAAACGTTCTTTCTCAAAGATTAGCCATTGAT
GTCATCCTTTCCTATATTAGACACATTTTCCAACTCCCGATGTCTTTCTTTTCGACTAGAAGAACAGGGGAAATTACCAG
TCGGTTTTCCGATGCCAGTTCTATTTTGGATGCTATTGCCTCAACGATTCTTTCGCTCTTTTTAGATTTAACCATTGTTC
TTATGACAGGACTGATTTTAGGGCTTCAAAATATGCAACTCTTTCTTCTCGTTCTTTTGGCAATCCCACTTTATATTGTT
GTTATTATTATTTTTACTCCGCTTTTTGAAAGACAAAATCATGAAGTTATGCAAACCAATGCCATCTTAAATTCCTCAAT
TATTGAAGACATTAATGGGATTGAAACCATCAAAGCGCTCGCCAGTGAACAAGAGAGATATCAAAAAATTGACTACGAAT
TTGCAAGTTATCTAAAAGAGGCTTTCACTTTACAACAGTCAGAAGCCATTCAGACGGCAATAAAAACGACAGTACAACTT
GTACTAAATGTTCTTATTTTATGGTTTGGTGCAACTTTAGTCATGCATCAAAAAATTACCCTCGGACAACTCATTACTTT
TAATGCCTTGCTTTCTTACTTTACAAATCCAATTACTAATATCATTAACCTTCAAACAAAACTACAAAAGGCAAGGGTAG
CCAATGAACGATTAAATGAGGTCTATCTTGTACCCAGTGAATTTGAAGAAAAGAAAACAGAACTGTCCCTCTCACATTTT
AATTTAAACATGTCTGAGATTTCATATCAATATGGTTTTGGCAGAAAAGTCTTATCTGAGATAAAACTGTCTATTAAAGA
AAATGAAAAGTTGACCATTGTTGGTATAAGCGGTTCAGGGAAGAGTACTCTTGTTAAATTATTGGTCAACTTCTTTCAAC
CCACTTCTGGTACCATTACTTTAGGTGGAATTGACCTTCAACAGTTTGATAAACATCAACTTCGACGATTAATCAACTAT
CTTCCCCAACAACCTTATATTTTCACAGGTTCAATTATGGATAATTTACTTTTAGGCGCTAGTGAAGCTACTTCACAAGA
AGAGATTATTAGAGCGGTGGAATTGGCAGAAATCCGTGCAGATATTGAACAAATGCAATTAGGTTATCAAACTGAACTCT
CAAGTGATGCAAGTAGTTTATCGGGAGGACAAAAACAGAGAATTGCGCTCGCTCGTGCCCTCCTTTCTCCTGCCAAAATA
CTCATCTTAGACGAAGCCACCAGTAATCTTGATATGATTACTGAAAAGAAAATATTAAAGAATTTGTTGGCACTAGATAA
GACAATTATTTTCATTGCTCACCGCCTCTCTGTAGCGGAAATGAGCCATCGTATCATTGTCATTGAACAAGGAAAAGTGA
TAGAAAGTGGTTCACATTCAGAACTGCTTGCTCAAAATGGCTTTTACGCACAACTTTACCATAACTAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-437)

ABC transporter (ABC_tran)

(498-648)

Peptidase C39 family (Peptidase_C39)

(6-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0V8DTP2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus gordonii str. Challis substr. CH1

61.204

99.86

0.611
  comA Streptococcus mitis NCTC 12261

60.224

99.86

0.601
  comA Streptococcus mitis SK321

60.084

99.86

0.6
  comA Streptococcus pneumoniae Rx1

59.804

99.86

0.597
  comA Streptococcus pneumoniae D39

59.804

99.86

0.597
  comA Streptococcus pneumoniae R6

59.804

99.86

0.597
  comA Streptococcus pneumoniae TIGR4

59.524

99.86

0.594
  comA/nlmT Streptococcus mutans UA159

58.774

100

0.59

Multiple sequence alignment