Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   BSR19_RS01035 Genome accession   NZ_CP018187
Coordinates   186953..187702 (+) Length   249 a.a.
NCBI ID   WP_021143484.1    Uniprot ID   A0A074IYL9
Organism   Streptococcus salivarius strain ICDC2     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 181953..192702
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BSR19_RS01015 (BSR19_01015) - 182968..183708 (-) 741 WP_002886432.1 amino acid ABC transporter ATP-binding protein -
  BSR19_RS01020 (BSR19_01020) - 183708..185255 (-) 1548 WP_156246333.1 ABC transporter substrate-binding protein/permease -
  BSR19_RS01025 (BSR19_01025) - 185461..186315 (+) 855 WP_002883622.1 undecaprenyl-diphosphate phosphatase -
  BSR19_RS01030 (BSR19_01030) - 186375..186746 (-) 372 WP_002889766.1 DUF3021 family protein -
  BSR19_RS01035 (BSR19_01035) mecA 186953..187702 (+) 750 WP_021143484.1 adaptor protein MecA Regulator
  BSR19_RS01040 (BSR19_01040) - 187706..188863 (+) 1158 WP_156246334.1 glycosyltransferase family 4 protein -
  BSR19_RS01045 (BSR19_01045) sufC 189025..189795 (+) 771 WP_002883600.1 Fe-S cluster assembly ATPase SufC -
  BSR19_RS01050 (BSR19_01050) sufD 189832..191094 (+) 1263 WP_156246335.1 Fe-S cluster assembly protein SufD -
  BSR19_RS01055 (BSR19_01055) - 191148..192380 (+) 1233 WP_156246336.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29086.66 Da        Isoelectric Point: 4.0182

>NTDB_id=206825 BSR19_RS01035 WP_021143484.1 186953..187702(+) (mecA) [Streptococcus salivarius strain ICDC2]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMDDYSGLSPEEFLKALEGNFMDKGDIEAHHKLEELEKTLEEVDKAMTEPTKEVAEENIREDYTHYVLAF
SDFDQVVTFTQGLKDVPVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRAYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=206825 BSR19_RS01035 WP_021143484.1 186953..187702(+) (mecA) [Streptococcus salivarius strain ICDC2]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAATT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTACACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGCGGGATGCTGAGCTTCCGTGTCACGCCACGCAAGGACCGTGTGGATGTCTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAACGATTTGTCAGATATGGACGACTACTCAGGGCTTTCTCCAGAAGAGTTCCTCAAGGCTCT
TGAAGGTAACTTTATGGACAAGGGGGATATCGAAGCACACCATAAGCTCGAAGAACTTGAGAAGACCTTGGAAGAAGTTG
ATAAGGCTATGACAGAGCCTACCAAGGAAGTGGCTGAAGAAAATATTCGTGAAGACTATACCCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTAGTGACCTTTACACAAGGCTTGAAGGATGTACCTGTTGAAGGTTCTGAGCTTTATAAGCTTGG
GGATGTCTACTATATGACAATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTGCCTACCTACAGGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTACTACAAGCAACGAAATGGAGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A074IYL9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

94.378

100

0.944
  mecA Streptococcus thermophilus LMG 18311

93.574

100

0.936
  mecA Streptococcus mutans UA159

60.246

97.992

0.59
  mecA Streptococcus pneumoniae Rx1

47.39

100

0.474
  mecA Streptococcus pneumoniae D39

47.39

100

0.474
  mecA Streptococcus pneumoniae R6

47.39

100

0.474
  mecA Streptococcus pneumoniae TIGR4

47.39

100

0.474

Multiple sequence alignment