Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EM4838_RS00050 Genome accession   NZ_CP018061
Coordinates   7254..8558 (-) Length   434 a.a.
NCBI ID   WP_066025889.1    Uniprot ID   A0A1I4L3Q4
Organism   Enterococcus mundtii strain DSM 4838     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2254..13558
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EM4838_RS16985 - 2267..2443 (+) 177 WP_250645098.1 aldehyde dehydrogenase family protein -
  EM4838_RS16990 - 2433..2672 (+) 240 WP_250645099.1 aldehyde dehydrogenase family protein -
  EM4838_RS00020 (EM4838_00020) - 2708..3666 (-) 959 Protein_7 glycosyltransferase family 2 protein -
  EM4838_RS00025 (EM4838_00025) - 3805..4155 (-) 351 WP_019724280.1 PepSY domain-containing protein -
  EM4838_RS00030 (EM4838_00030) pepA 4356..5435 (+) 1080 WP_019724279.1 glutamyl aminopeptidase -
  EM4838_RS00035 (EM4838_00035) - 5559..5879 (+) 321 WP_071866164.1 thioredoxin family protein -
  EM4838_RS00040 (EM4838_00040) - 5901..6355 (+) 455 Protein_11 universal stress protein -
  EM4838_RS00045 (EM4838_00045) ytpR 6602..7207 (+) 606 WP_071866223.1 YtpR family tRNA-binding protein -
  EM4838_RS00050 (EM4838_00050) htrA 7254..8558 (-) 1305 WP_066025889.1 S1C family serine protease Regulator
  EM4838_RS00055 (EM4838_00055) rlmH 8986..9465 (+) 480 WP_034689953.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EM4838_RS00060 (EM4838_00060) - 9550..10046 (+) 497 Protein_15 DUF1456 family protein -
  EM4838_RS00065 (EM4838_00065) - 10146..10781 (+) 636 WP_010728617.1 hypothetical protein -
  EM4838_RS00070 (EM4838_00070) - 11232..12169 (+) 938 Protein_17 2-dehydropantoate 2-reductase -
  EM4838_RS00075 (EM4838_00075) - 12182..13234 (+) 1053 WP_002291912.1 PTS sugar transporter subunit IIC -

Sequence

Protein


Download         Length: 434 a.a.        Molecular weight: 45124.02 Da        Isoelectric Point: 4.4469

>NTDB_id=205517 EM4838_RS00050 WP_066025889.1 7254..8558(-) (htrA) [Enterococcus mundtii strain DSM 4838]
MDRRDVTPKMKKRKSNGIWRKLGLGVVGGVIGGLLTFGIFYAATGGGNSVTTSSSSGTQNASGETVVENVKVNVDSDITS
AVDKVQGAVVSVINLQKQSSSSDPFGSLFGQQQESSGEDGELQAYSEGSGVIYKKEGDSAYIVTNNHVVDGQQGLEVLLK
DGTKVKAELVGTDAYTDLAVLKISADKVDTVASFGDSASLKVGEPAIAIGSPLGSQYANSVTSGIVSSLNRQVTSTNESN
ETVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSDSSSVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMTDLSAVSTQQQEQILKLPSSVTNGVIIRSVQPATPAEKAGLEQYDVITKIDDTEVSSGVELQSVLYGKKVGDTVKIT
YYRGEEEKTVDIKLTIDNTALNQGNSNSSNGSNN

Nucleotide


Download         Length: 1305 bp        

>NTDB_id=205517 EM4838_RS00050 WP_066025889.1 7254..8558(-) (htrA) [Enterococcus mundtii strain DSM 4838]
ATGGACAGAAGAGATGTGACACCAAAAATGAAAAAAAGAAAATCTAATGGCATTTGGCGAAAGCTAGGTCTTGGCGTAGT
TGGTGGCGTGATTGGCGGATTACTGACTTTCGGTATTTTTTATGCAGCAACTGGAGGTGGTAACTCAGTAACGACTTCTT
CTAGCAGTGGGACACAAAATGCATCAGGCGAAACAGTTGTCGAAAATGTAAAAGTCAATGTAGATTCAGATATCACTTCT
GCAGTAGATAAAGTGCAAGGAGCAGTTGTTTCTGTTATCAACCTACAAAAACAAAGTTCATCATCTGACCCGTTTGGTTC
ATTATTTGGCCAACAACAAGAAAGTAGTGGCGAAGATGGCGAATTGCAAGCTTACAGTGAAGGTAGCGGTGTGATTTATA
AAAAAGAGGGCGATTCCGCTTATATCGTGACGAATAATCACGTTGTCGATGGACAACAAGGACTAGAAGTTTTACTAAAA
GATGGAACAAAAGTGAAAGCAGAATTAGTCGGTACAGATGCTTATACTGATTTAGCTGTTTTAAAAATCAGTGCTGACAA
AGTCGATACTGTTGCTTCATTTGGCGACTCTGCTTCATTGAAAGTCGGCGAACCTGCGATTGCGATTGGTTCTCCTCTAG
GTTCTCAATACGCAAACTCGGTGACATCAGGAATTGTTTCTTCCTTGAATCGTCAAGTGACAAGTACAAATGAATCTAAT
GAGACAGTGAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCAGGGAACTCTGGTGGTCCACTAGTTAATATCGA
AGGCCAAGTTATTGGTATCAATTCAAGTAAAATTGCATCGACTTCTGATTCTTCAAGTGTAAGTGTTGAAGGAATGGGCT
TTGCGATTCCAAGTAATGATGTCGTAAATATCATCAATCAACTTGAAAAAGATGGAAAAGTAACACGCCCTGCACTGGGT
ATCACAATGACCGATCTTTCCGCCGTTTCTACACAACAACAGGAACAGATCTTGAAATTACCATCTTCTGTAACAAATGG
CGTGATCATTCGTTCGGTTCAACCAGCAACGCCTGCGGAAAAAGCTGGCTTAGAACAATATGATGTCATCACAAAAATCG
ATGATACAGAAGTCTCATCTGGTGTTGAATTACAGTCTGTGCTTTATGGTAAAAAAGTTGGTGACACTGTGAAGATCACT
TATTACCGTGGCGAAGAAGAAAAAACTGTAGATATCAAATTGACAATTGATAATACTGCATTAAATCAAGGAAATTCAAA
TAGTTCCAATGGCTCAAATAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(13-416)

Trypsin-like peptidase domain (Trypsin_2)

(128-273)

PDZ domain (PDZ_2)

(317-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1I4L3Q4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

56.522

90.092

0.509
  htrA Streptococcus gordonii str. Challis substr. CH1

53.598

92.857

0.498
  htrA Streptococcus mitis NCTC 12261

53.03

91.244

0.484
  htrA Streptococcus pneumoniae Rx1

58.929

77.419

0.456
  htrA Streptococcus pneumoniae D39

58.929

77.419

0.456
  htrA Streptococcus pneumoniae R6

58.929

77.419

0.456
  htrA Streptococcus pneumoniae TIGR4

58.929

77.419

0.456

Multiple sequence alignment