Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SPG_0728 Genome accession   CP001015
Coordinates   706799..707473 (+) Length   224 a.a.
NCBI ID   ACF56723.1    Uniprot ID   -
Organism   Streptococcus pneumoniae G54     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 701799..712473
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPG_0724 - 702259..702759 (+) 501 ACF55223.1 MutT/nudix family protein -
  SPG_0725 - 702737..703606 (+) 870 ACF56707.1 conserved hypothetical protein -
  SPG_0726 - 703581..704021 (+) 441 ACF54919.1 conserved hypothetical protein -
  SPG_0727 - 704144..706690 (+) 2547 ACF56451.1 aminopeptidase N -
  SPG_0728 ciaR 706799..707473 (+) 675 ACF56723.1 CiaR response regulator TCS05 Regulator
  SPG_0729 ciaH 707463..708797 (+) 1335 ACF56115.1 CiaH histidine kinase TCS05 Regulator
  SPG_0730 - 708831..709118 (-) 288 ACF54948.1 conserved hypothetical protein -
  SPG_0731 - 709258..710187 (+) 930 ACF56768.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=20189 SPG_0728 ACF56723.1 706799..707473(+) (ciaR) [Streptococcus pneumoniae G54]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=20189 SPG_0728 ACF56723.1 706799..707473(+) (ciaR) [Streptococcus pneumoniae G54]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTNTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

100

100

1
  ciaR Streptococcus pneumoniae D39

100

100

1
  ciaR Streptococcus pneumoniae R6

100

100

1
  ciaR Streptococcus pneumoniae TIGR4

100

100

1
  ciaR Streptococcus mutans UA159

88.393

100

0.884
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment