Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   Spy49_0032 Genome accession   CP000829
Coordinates   53471..54391 (+) Length   306 a.a.
NCBI ID   ACI60395.1    Uniprot ID   -
Organism   Streptococcus pyogenes NZ131     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 48471..59391
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Spy49_0028 purE 48621..49232 (+) 612 ACI60391.1 Phosphoribosylaminoimidazole carboxylase catalytic subunit -
  Spy49_0029 purK 49216..50292 (+) 1077 ACI60392.1 Phosphoribosylaminoimidazole carboxylase ATPase subunit -
  Spy49_0030 - 50394..51875 (+) 1482 ACI60393.1 hypothetical protein -
  Spy49_0031 purB 52048..53340 (+) 1293 ACI60394.1 Adenylosuccinate lyase -
  Spy49_0032 comR 53471..54391 (+) 921 ACI60395.1 Transcriptional regulator, Cro/CI family Regulator
  Spy49_0033 ruvB 54617..55615 (+) 999 ACI60396.1 Holliday junction DNA helicase ruvB -
  Spy49_0035 - 55753..56190 (+) 438 ACI60397.1 Low molecular weight protein tyrosine phosphatase -
  Spy49_0036 - 56213..56614 (+) 402 ACI60398.1 hypothetical protein -
  Spy49_0037 - 56611..58386 (+) 1776 ACI60399.1 Putative acyltransferase -

Sequence

Protein


Download         Length: 306 a.a.        Molecular weight: 36114.64 Da        Isoelectric Point: 4.4270

>NTDB_id=20119 Spy49_0032 ACI60395.1 53471..54391(+) (comR) [Streptococcus pyogenes NZ131]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQK
IMAKIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 921 bp        

>NTDB_id=20119 Spy49_0032 ACI60395.1 53471..54391(+) (comR) [Streptococcus pyogenes NZ131]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTAGATGAATTATTTATAGTTAATAAGA
TTATCATTGATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAA
ATTATGGCGAAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAA
AGATATAATAAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACA
AGTTAATTCAAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-299)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.02

100

0.99
  comR Streptococcus pyogenes MGAS315

57.895

99.346

0.575
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

50.847

96.405

0.49
  comR Streptococcus mutans UA159

45.902

99.673

0.458

Multiple sequence alignment