Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   BHS03_RS09020 Genome accession   NZ_CP017197
Coordinates   1793518..1795671 (-) Length   717 a.a.
NCBI ID   WP_097001572.1    Uniprot ID   -
Organism   Leuconostoc gasicomitatum strain TMW 2.1619     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1772168..1803160 1793518..1795671 within 0


Gene organization within MGE regions


Location: 1772168..1803160
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BHS03_RS08890 (BHS03_08840) - 1772168..1773382 (-) 1215 WP_097001772.1 ATP-binding protein -
  BHS03_RS08895 (BHS03_08845) - 1773447..1773713 (-) 267 WP_097001771.1 hypothetical protein -
  BHS03_RS08900 (BHS03_08850) - 1773747..1773998 (-) 252 WP_010388215.1 hypothetical protein -
  BHS03_RS08905 (BHS03_08855) - 1774368..1774559 (-) 192 WP_224132391.1 hypothetical protein -
  BHS03_RS08910 (BHS03_08860) - 1774708..1776489 (-) 1782 WP_152338930.1 ABC transporter ATP-binding protein -
  BHS03_RS08915 (BHS03_08865) - 1776594..1777205 (-) 612 WP_010388204.1 MarR family winged helix-turn-helix transcriptional regulator -
  BHS03_RS08920 (BHS03_08870) - 1777546..1777827 (-) 282 WP_224132393.1 DUF2087 domain-containing protein -
  BHS03_RS08925 (BHS03_08875) - 1777824..1778288 (-) 465 WP_089997681.1 hypothetical protein -
  BHS03_RS08930 (BHS03_08880) - 1778346..1779209 (-) 864 WP_152338822.1 IS3 family transposase -
  BHS03_RS08935 (BHS03_08885) - 1779173..1779448 (-) 276 WP_060391135.1 transposase -
  BHS03_RS08945 (BHS03_08890) - 1779770..1780705 (+) 936 WP_097001582.1 DMT family transporter -
  BHS03_RS08950 (BHS03_08895) - 1780788..1781828 (-) 1041 WP_097001581.1 SDR family oxidoreductase -
  BHS03_RS08955 (BHS03_08900) - 1781958..1782518 (+) 561 WP_097001580.1 TetR/AcrR family transcriptional regulator -
  BHS03_RS08960 (BHS03_08905) - 1782900..1784129 (-) 1230 WP_097001579.1 MFS transporter -
  BHS03_RS08965 (BHS03_08910) - 1784129..1784902 (-) 774 WP_060391071.1 amino acid ABC transporter ATP-binding protein -
  BHS03_RS08970 (BHS03_08915) - 1784913..1785884 (-) 972 WP_097001577.1 D-2-hydroxyacid dehydrogenase -
  BHS03_RS08975 (BHS03_08920) - 1785915..1787138 (-) 1224 WP_010388105.1 PLP-dependent aminotransferase family protein -
  BHS03_RS08980 (BHS03_08925) - 1787169..1787906 (-) 738 WP_090090259.1 amino acid ABC transporter ATP-binding protein -
  BHS03_RS08985 (BHS03_08930) - 1787909..1788613 (-) 705 WP_010015529.1 amino acid ABC transporter permease -
  BHS03_RS08990 (BHS03_08935) - 1788626..1789453 (-) 828 WP_097001576.1 transporter substrate-binding domain-containing protein -
  BHS03_RS08995 (BHS03_08940) - 1789508..1790254 (-) 747 WP_010388100.1 amino acid ABC transporter permease -
  BHS03_RS09000 (BHS03_08945) - 1790634..1790873 (-) 240 WP_097001575.1 hypothetical protein -
  BHS03_RS09005 (BHS03_08950) - 1791008..1791307 (-) 300 WP_097001574.1 bacteriocin immunity protein -
  BHS03_RS09010 (BHS03_08955) - 1791874..1792134 (-) 261 WP_090090262.1 helix-turn-helix domain-containing protein -
  BHS03_RS09015 (BHS03_08960) - 1792127..1793503 (-) 1377 WP_097001573.1 bacteriocin secretion accessory protein -
  BHS03_RS09020 (BHS03_08965) comA 1793518..1795671 (-) 2154 WP_097001572.1 peptide cleavage/export ABC transporter Regulator
  BHS03_RS09025 (BHS03_08970) - 1795865..1796059 (-) 195 WP_097001571.1 hypothetical protein -
  BHS03_RS10200 - 1796426..1796626 (-) 201 WP_097001570.1 IS3 family transposase -
  BHS03_RS10205 - 1796706..1796861 (-) 156 WP_097001569.1 DDE-type integrase/transposase/recombinase -
  BHS03_RS09045 (BHS03_08975) - 1796988..1797191 (-) 204 WP_193599896.1 hypothetical protein -
  BHS03_RS09055 (BHS03_08980) - 1797695..1797970 (+) 276 WP_097001567.1 helix-turn-helix domain-containing protein -
  BHS03_RS09060 (BHS03_08985) - 1798077..1798277 (+) 201 WP_097001566.1 leucocin A/sakacin P family class II bacteriocin -
  BHS03_RS09065 (BHS03_08990) - 1798253..1798561 (+) 309 WP_097001565.1 bacteriocin immunity protein -
  BHS03_RS09070 (BHS03_08995) - 1798816..1799304 (+) 489 WP_097001564.1 PedC/BrcD family bacteriocin maturation disulfide isomerase -
  BHS03_RS10210 - 1799458..1799652 (-) 195 WP_179304120.1 IS3 family transposase -
  BHS03_RS10215 - 1799937..1800233 (+) 297 WP_097001562.1 hypothetical protein -
  BHS03_RS10220 - 1800422..1800580 (+) 159 WP_179304121.1 hypothetical protein -
  BHS03_RS09085 (BHS03_09005) - 1800834..1801109 (+) 276 WP_060391135.1 transposase -
  BHS03_RS09090 (BHS03_09010) - 1801169..1801702 (+) 534 WP_152338932.1 DDE-type integrase/transposase/recombinase -
  BHS03_RS09095 - 1801719..1801937 (+) 219 WP_179304123.1 integrase core domain-containing protein -
  BHS03_RS09100 (BHS03_09015) - 1802420..1803160 (+) 741 WP_097001299.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 79480.69 Da        Isoelectric Point: 6.0053

>NTDB_id=196636 BHS03_RS09020 WP_097001572.1 1793518..1795671(-) (comA) [Leuconostoc gasicomitatum strain TMW 2.1619]
MFIKKINYIPQVDERDCGVAALAMIMAHYNTRMSLAQLREMAKTDMEGTTALGIVKAAQALDFDTMPVQADLSMFDKKDL
PYPFIAHVQKDGKYPHYYVVYGMKGQNLLIADPDITVGRTKMAKSYFVNEWTGVAIFIAPNPIYKPTKDKKRSLSSFIPV
IGKQRGLVINIVIAALMVTLVSILGSYYLQGIIDTYIPDNMKSTLGIVSVGLIVAYVIQQMLSYARDYLLIIMGQRLSID
IILSYIKHIFELPMSFFATRRTGEIISRFTDANSIIEALASTMLSLFLDVGILVIVGTVLVIQNSTLFFISLVAVPAYSL
VIWLFMKPFSKMNNDQMQAGSMLSASIIEDINGVETIKALNSEQVAYKKVDHEFVTYLDKSFIYAKTEAVQNALKSLLHL
ILNVLVLWVGAQLVMANKISMGQLITYNALLGFFTDPLQNIINLQTKLQQASVANNRLNEVYLVESEYKEPSALSERIAD
ASDIIMTQVTYKYGFGAPAIDDVSLQIGQGEKIALVGVSGSGKSTLVKLLVNFFHPESGTIMLGNSTLENIDKHELRAHI
NYLPQEPYIFTGSIIENLMLGAKPSTTQADIIRATELAEIKIDIENMSQGFSTELAESGNISGGQKQRIALARALLVDSP
VLILDESTSNLDVLTEKKIIDNLMKLTDKTIIFVAHRLTISQKVQRIIAMQSGKIIEDGSHDELLEQAGFYASLFND

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=196636 BHS03_RS09020 WP_097001572.1 1793518..1795671(-) (comA) [Leuconostoc gasicomitatum strain TMW 2.1619]
ATGTTTATCAAAAAAATTAATTATATTCCGCAAGTTGATGAACGTGATTGTGGTGTTGCAGCGTTAGCCATGATCATGGC
GCATTATAATACACGAATGTCATTAGCACAGTTACGTGAAATGGCCAAGACAGACATGGAGGGAACGACAGCATTAGGAA
TCGTTAAGGCAGCACAAGCGCTTGATTTCGATACAATGCCAGTTCAGGCAGATCTATCTATGTTTGATAAGAAGGACTTA
CCTTATCCGTTTATTGCACATGTTCAAAAAGATGGCAAGTATCCACATTATTACGTTGTTTATGGTATGAAGGGACAAAA
TCTATTAATTGCTGATCCTGATATTACCGTTGGTAGGACTAAAATGGCAAAATCCTATTTTGTTAATGAATGGACTGGTG
TAGCCATATTTATTGCTCCCAATCCAATTTATAAACCAACCAAAGATAAGAAACGTTCGCTAAGCTCTTTTATACCGGTT
ATCGGTAAGCAACGTGGATTAGTGATTAATATTGTGATCGCAGCACTTATGGTGACTTTGGTTAGTATTTTAGGATCTTA
TTATTTGCAGGGAATTATTGATACCTATATACCAGATAATATGAAGAGCACGCTGGGCATTGTGTCTGTCGGTTTAATTG
TAGCCTATGTGATACAGCAGATGTTGTCATATGCCAGAGATTACTTATTAATTATCATGGGTCAACGATTATCAATTGAC
ATTATTCTGTCCTATATTAAGCATATTTTTGAATTACCAATGTCTTTTTTTGCAACAAGACGGACCGGTGAAATTATTAG
CCGTTTCACTGATGCGAATTCTATTATCGAAGCTTTAGCCAGTACAATGCTGTCCTTATTTTTAGACGTTGGTATATTAG
TTATAGTCGGAACAGTGTTAGTGATTCAAAATTCAACGTTGTTTTTTATCTCATTAGTAGCAGTACCAGCTTATTCTTTA
GTGATATGGCTCTTTATGAAGCCATTTTCTAAGATGAACAACGATCAAATGCAAGCCGGATCGATGTTGAGCGCCTCAAT
CATTGAAGACATTAATGGTGTTGAAACAATTAAAGCATTGAACAGTGAACAAGTTGCGTATAAAAAAGTAGATCATGAAT
TTGTCACGTATTTGGATAAATCATTTATCTATGCAAAAACTGAAGCAGTTCAAAATGCACTCAAAAGTTTATTGCACTTG
ATTTTGAATGTTTTAGTACTTTGGGTTGGCGCGCAGTTAGTCATGGCTAACAAAATAAGCATGGGTCAGTTGATCACATA
TAATGCTTTGCTTGGATTTTTTACAGATCCACTACAAAACATTATCAACTTACAAACTAAGTTGCAACAAGCTTCAGTTG
CTAATAATCGTTTAAATGAAGTGTATTTAGTTGAGTCAGAATATAAAGAACCGTCAGCATTAAGTGAAAGAATTGCAGAT
GCTAGTGATATCATTATGACACAAGTAACTTATAAATACGGCTTTGGTGCACCTGCGATTGATGACGTGTCACTTCAAAT
TGGGCAAGGTGAAAAAATTGCTTTAGTTGGTGTGAGTGGTTCGGGGAAATCGACGTTAGTGAAGTTGTTAGTTAATTTTT
TTCACCCGGAATCTGGCACAATTATGCTAGGCAATAGTACGTTAGAAAATATTGATAAACATGAACTACGTGCGCATATT
AATTACCTCCCACAAGAACCATATATTTTTACGGGTTCAATTATTGAAAATTTGATGTTAGGTGCGAAGCCTAGTACAAC
ACAAGCAGATATTATACGCGCAACTGAATTAGCTGAAATTAAAATTGATATTGAAAACATGTCACAAGGATTTAGTACAG
AATTAGCTGAGAGTGGGAATATTTCAGGTGGTCAAAAGCAGCGGATTGCTTTAGCACGAGCTCTGCTGGTTGATTCACCC
GTCTTAATTCTTGATGAATCGACTAGTAATTTAGATGTGTTAACTGAAAAGAAGATTATTGATAATTTAATGAAGTTAAC
TGATAAAACGATTATTTTTGTGGCACATCGTCTGACCATATCACAAAAAGTACAGCGCATTATTGCTATGCAATCAGGTA
AAATAATTGAAGACGGGTCTCATGATGAATTACTAGAACAAGCGGGCTTCTATGCCTCTTTGTTTAATGATTAG

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(168-438)

Peptidase C39 family (Peptidase_C39)

(6-142)

ABC transporter (ABC_tran)

(501-649)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

60.53

100

0.605
  comA Streptococcus gordonii str. Challis substr. CH1

60.391

100

0.604
  comA Streptococcus mitis SK321

60.112

100

0.601
  comA Streptococcus pneumoniae D39

59.833

100

0.598
  comA Streptococcus pneumoniae Rx1

59.833

100

0.598
  comA Streptococcus pneumoniae R6

59.833

100

0.598
  comA Streptococcus pneumoniae TIGR4

59.693

100

0.597
  comA/nlmT Streptococcus mutans UA159

58.051

98.745

0.573

Multiple sequence alignment