Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   BHS01_RS10500 Genome accession   NZ_CP017195
Coordinates   2150752..2151999 (+) Length   415 a.a.
NCBI ID   WP_109835185.1    Uniprot ID   A0A7L4WG41
Organism   Lactococcus paracarnosus strain TMW 2.1615     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2145752..2156999
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BHS01_RS10475 (BHS01_10475) - 2146490..2147833 (-) 1344 WP_109835180.1 PLP-dependent aminotransferase family protein -
  BHS01_RS10480 (BHS01_10480) - 2147925..2148770 (+) 846 WP_109835181.1 NAD-dependent epimerase/dehydratase family protein -
  BHS01_RS11555 - 2148799..2148978 (+) 180 WP_109835182.1 DUF2798 domain-containing protein -
  BHS01_RS10490 (BHS01_10485) - 2149201..2149878 (-) 678 WP_188347998.1 YoaK family protein -
  BHS01_RS10495 (BHS01_10490) rlmH 2149977..2150453 (-) 477 WP_109835184.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  BHS01_RS10500 (BHS01_10495) htrA 2150752..2151999 (+) 1248 WP_109835185.1 S1C family serine protease Regulator
  BHS01_RS10505 (BHS01_10500) - 2152079..2152408 (-) 330 WP_109835186.1 bacteriocin immunity protein -
  BHS01_RS10515 (BHS01_10510) - 2152785..2153783 (+) 999 WP_109835187.1 glycosyltransferase -
  BHS01_RS10520 (BHS01_10515) - 2153886..2155217 (+) 1332 WP_109835188.1 glycosyltransferase family 4 protein -
  BHS01_RS10525 (BHS01_10520) - 2155276..2155500 (+) 225 WP_047916414.1 DUF1797 family protein -
  BHS01_RS10530 (BHS01_10525) - 2155550..2155816 (-) 267 WP_109835189.1 GIY-YIG nuclease family protein -
  BHS01_RS10535 (BHS01_10530) - 2155809..2156555 (-) 747 WP_109835190.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 415 a.a.        Molecular weight: 43149.37 Da        Isoelectric Point: 5.5606

>NTDB_id=196593 BHS01_RS10500 WP_109835185.1 2150752..2151999(+) (htrA) [Lactococcus paracarnosus strain TMW 2.1615]
MKTNRKTAATLLTAGIIGGAVALGGNAVYDHFNTTGTALNTSSTATKVDNTAYKVTSDTTKAISKVSDAVVSVINYQKAP
ESGSSIDDLFGDRDNTKKKDDTKEQPAAEGSGVIYKKDGDTAYVVTNNHVVDGASSLEILLSNGNKVKGTLVGKDAYSDL
AVIKISAKDVAKVATFGDSTKLTVGEPAIAIGSPLGSQYANSATEGIISSLSRQVIMKNESNETVNINALQTDAAINPGN
SGGALINVEGQVIGINSSKISATGASSSDVSVEGMGFAIPSNDVVSIISKLEKDGEIKRPALGVQMLDLASISSQNQDQL
KLPSSVTAGVVIAKVQDGLPAAAAGLKKYDVITKIGDTKITSGTELQTALYKYNIGDSMKITYYRDGKESTATIKLDNTS
DKLKFDDAEKKNTDK

Nucleotide


Download         Length: 1248 bp        

>NTDB_id=196593 BHS01_RS10500 WP_109835185.1 2150752..2151999(+) (htrA) [Lactococcus paracarnosus strain TMW 2.1615]
ATGAAAACAAATAGAAAAACAGCTGCAACATTACTCACTGCTGGTATTATAGGTGGTGCTGTCGCCCTCGGTGGTAACGC
CGTTTACGACCATTTTAATACGACTGGTACAGCCCTAAATACTAGCAGCACTGCTACTAAGGTCGATAATACAGCCTACA
AAGTCACAAGTGACACAACCAAGGCAATCAGCAAAGTATCTGATGCGGTCGTCTCTGTTATCAACTACCAAAAAGCACCG
GAAAGCGGATCTTCCATCGATGATCTTTTTGGTGACCGTGATAATACGAAAAAGAAAGATGATACAAAAGAACAACCTGC
AGCAGAAGGGTCTGGGGTTATCTATAAAAAAGATGGCGATACTGCCTATGTTGTTACTAATAACCATGTTGTAGACGGCG
CTAGCTCGCTAGAAATCCTGCTCTCTAACGGCAATAAAGTAAAAGGTACATTGGTTGGTAAAGATGCTTATAGTGATTTA
GCTGTCATCAAGATATCTGCAAAAGATGTCGCTAAAGTAGCCACTTTTGGTGATTCAACAAAACTAACTGTTGGTGAACC
CGCTATCGCGATTGGCTCTCCTCTCGGCAGCCAGTATGCCAACTCAGCAACTGAAGGGATTATCTCTAGTCTATCAAGAC
AAGTCATCATGAAAAACGAAAGTAACGAGACGGTTAATATTAATGCCTTGCAAACAGATGCAGCAATTAACCCTGGTAAC
TCTGGTGGTGCGCTCATTAATGTAGAGGGTCAAGTCATCGGCATCAACTCAAGTAAAATTTCGGCAACAGGCGCCTCTTC
AAGTGATGTTTCCGTTGAAGGAATGGGGTTTGCTATCCCGTCAAATGATGTTGTAAGCATCATCAGCAAGCTTGAAAAAG
ATGGGGAAATCAAACGTCCAGCACTTGGTGTTCAAATGCTTGATCTTGCAAGTATCAGCTCACAAAATCAAGACCAACTC
AAACTCCCTAGCTCAGTCACTGCTGGTGTTGTGATCGCTAAAGTTCAAGATGGTCTACCTGCTGCTGCTGCTGGTCTTAA
GAAATACGATGTCATCACTAAAATTGGGGATACCAAGATCACAAGTGGTACTGAACTCCAGACAGCACTTTACAAATATA
ATATTGGGGATAGCATGAAAATCACCTATTATCGTGATGGTAAAGAAAGCACTGCTACTATTAAACTAGATAATACATCA
GATAAATTGAAGTTTGATGATGCTGAAAAGAAAAATACTGATAAATAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(300-396)

Peptidase family M50 (Peptidase_M50)

(277-401)

Trypsin-like peptidase domain (Trypsin_2)

(110-255)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7L4WG41

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

55.584

94.94

0.528
  htrA Streptococcus mutans UA159

57.373

89.88

0.516
  htrA Streptococcus mitis NCTC 12261

54.67

87.711

0.48
  htrA Streptococcus pneumoniae TIGR4

54.342

86.024

0.467
  htrA Streptococcus pneumoniae Rx1

54.342

86.024

0.467
  htrA Streptococcus pneumoniae D39

54.342

86.024

0.467
  htrA Streptococcus pneumoniae R6

54.342

86.024

0.467

Multiple sequence alignment