Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   A7J08_RS08650 Genome accession   NZ_CP017088
Coordinates   1732143..1732865 (-) Length   240 a.a.
NCBI ID   WP_053866718.1    Uniprot ID   A0A3Q8BNN5
Organism   Streptococcus suis strain SRD478     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1727143..1737865
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A7J08_RS08630 (A7J08_08415) - 1727289..1728512 (-) 1224 WP_053867468.1 cysteine desulfurase -
  A7J08_RS08635 (A7J08_08420) sufD 1728516..1729778 (-) 1263 WP_148115840.1 Fe-S cluster assembly protein SufD -
  A7J08_RS08640 (A7J08_08425) sufC 1729795..1730568 (-) 774 WP_024376584.1 Fe-S cluster assembly ATPase SufC -
  A7J08_RS08645 (A7J08_08430) - 1730974..1732146 (-) 1173 WP_002938168.1 MraY family glycosyltransferase -
  A7J08_RS08650 (A7J08_08435) mecA 1732143..1732865 (-) 723 WP_053866718.1 adaptor protein MecA Regulator
  A7J08_RS08655 (A7J08_08440) - 1732993..1733829 (-) 837 WP_053866717.1 undecaprenyl-diphosphate phosphatase -
  A7J08_RS08660 (A7J08_08445) - 1733956..1735521 (+) 1566 WP_053866716.1 ABC transporter substrate-binding protein/permease -
  A7J08_RS08665 (A7J08_08450) - 1735514..1736257 (+) 744 WP_012775335.1 amino acid ABC transporter ATP-binding protein -
  A7J08_RS08670 (A7J08_08455) - 1736380..1736589 (-) 210 WP_009910800.1 hypothetical protein -
  A7J08_RS08675 (A7J08_08460) - 1736675..1737577 (-) 903 WP_002942264.1 SPFH domain-containing protein -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 27957.51 Da        Isoelectric Point: 4.0497

>NTDB_id=195417 A7J08_RS08650 WP_053866718.1 1732143..1732865(-) (mecA) [Streptococcus suis strain SRD478]
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDL
DQSLNFDEFTDLSELGDVASMTPDEFFKSLEQTVREKSAPDATAVRHLEEVEQEEEADEEEQERYIYYILEFPTIEDLFT
FIGTVDYPVEESELYKMDGHYYLTVLINVENRSKQYPGYILSRMLEFTNDAKLTRPALQEHGTLMLPLAAIEELRKVPTV

Nucleotide


Download         Length: 723 bp        

>NTDB_id=195417 A7J08_RS08650 WP_053866718.1 1732143..1732865(-) (mecA) [Streptococcus suis strain SRD478]
ATGAAAGTAAAGCAAATTAGTGATTCAACCTTGAAAATCACTATAAAATTAGATGATTTAGAAGAGAGAGGAATGGAACT
TTCGGACTTTCTCATTCCGCAAGAAAAGACAGAGGAGTTCTTCTATACTGTTTTGGATGAATTGGATTTACCAATGACTT
TCCGAGAAAGCGGTATGCTGAGTTTTCGTGTGACTCCGAAGCCAGATCGGGTGGACATCTTTGTTACCAAGTCTGATTTG
GATCAGAGCTTGAATTTCGATGAATTTACAGATTTGTCGGAACTTGGTGATGTCGCAAGTATGACTCCAGATGAGTTTTT
CAAGAGTTTGGAGCAAACCGTTCGTGAGAAAAGTGCACCGGATGCAACAGCCGTTCGTCATTTGGAAGAGGTAGAGCAAG
AGGAAGAAGCAGATGAAGAGGAGCAGGAGCGCTATATTTACTATATTTTGGAATTTCCAACGATAGAGGATCTGTTTACT
TTTATTGGTACGGTTGATTATCCAGTAGAAGAATCGGAATTATATAAAATGGATGGTCACTACTACTTGACCGTTCTTAT
CAATGTAGAAAATCGTTCCAAGCAGTATCCAGGCTACATTCTCTCACGGATGTTGGAATTTACCAATGATGCGAAGTTGA
CTAGACCTGCTTTACAAGAACACGGAACTTTGATGCTTCCGCTTGCGGCAATCGAGGAGCTTAGGAAGGTTCCGACAGTA
TGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3Q8BNN5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

51.639

100

0.525
  mecA Streptococcus pneumoniae D39

51.639

100

0.525
  mecA Streptococcus pneumoniae R6

51.639

100

0.525
  mecA Streptococcus pneumoniae TIGR4

51.639

100

0.525
  mecA Streptococcus mutans UA159

50

100

0.508
  mecA Streptococcus thermophilus LMD-9

47.917

100

0.479
  mecA Streptococcus thermophilus LMG 18311

47.5

100

0.475

Multiple sequence alignment