Detailed information NTG0194427

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: CCX85_RS02115
• Genome accession: NZ_CP021640
• Coordinates: 391718..393871 (-)
• Length: 717 a.a.
• NCBI ID: WP_032464223.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain JS12
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 386718..398871

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CCX85_RS02095 (CCX85_02105)	comE/blpR	387909..388658 (+)	750	WP_002992578.1	response regulator transcription factor	Regulator
CCX85_RS02100 (CCX85_02110)	-	388659..389993 (+)	1335	WP_014635339.1	sensor histidine kinase	-
CCX85_RS02105 (CCX85_02115)	-	390141..390266 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
CCX85_RS02110 (CCX85_02120)	-	390343..391707 (-)	1365	WP_101248309.1	bacteriocin secretion accessory protein	-
CCX85_RS02115 (CCX85_02125)	comA/nlmT	391718..393871 (-)	2154	WP_032464223.1	peptide cleavage/export ABC transporter	Regulator
CCX85_RS02120 (CCX85_02130)	-	394148..394372 (+)	225	WP_030126106.1	Blp family class II bacteriocin	-
CCX85_RS02125 (CCX85_02135)	-	394449..394667 (+)	219	WP_030126105.1	bacteriocin	-
CCX85_RS02135 (CCX85_02145)	-	395193..395594 (+)	402	WP_032466306.1	hypothetical protein	-
CCX85_RS02140 (CCX85_02150)	-	395845..396914 (+)	1070	Protein_365	hypothetical protein	-
CCX85_RS02145 (CCX85_02155)	-	397007..397405 (+)	399	WP_011054254.1	hypothetical protein	-
CCX85_RS02150 (CCX85_02160)	stcA	397753..398022 (-)	270	WP_023605037.1	quorum-sensing system protein StcA	-
CCX85_RS09445 (CCX85_02165)	-	398544..398786 (-)	243	WP_002985713.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80558.55 Da
• Isoelectric Point: 7.1729

>NTDB_id=194427 CCX85_RS02115 WP_032464223.1 391718..393871(-) (comA/nlmT) [Streptococcus pyogenes strain JS12]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILKQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=194427 CCX85_RS02115 WP_032464223.1 391718..393871(-) (comA/nlmT) [Streptococcus pyogenes strain JS12]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCAAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTTCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• ABC transporter (ABC_tran) (500-649)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.727	99.721	0.725
comA	Streptococcus mitis NCTC 12261	67.507	99.582	0.672
comA	Streptococcus mitis SK321	67.087	99.582	0.668
comA	Streptococcus pneumoniae Rx1	67.087	99.582	0.668
comA	Streptococcus pneumoniae D39	67.087	99.582	0.668
comA	Streptococcus pneumoniae R6	67.087	99.582	0.668
comA	Streptococcus pneumoniae TIGR4	66.807	99.582	0.665
comA	Streptococcus gordonii str. Challis substr. CH1	65.877	100	0.66