NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	A6J82_RS04015	Genome accession	NZ_CP020449
Coordinates	727377..728051 (+)	Length	224 a.a.
NCBI ID	WP_001238594.1	Uniprot ID	P0A4I0
Organism	Streptococcus agalactiae strain FDAARGOS_254
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 722377..733051

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J82_RS03995 (A6J82_04015)	-	722560..723777 (+)	1218	WP_001291561.1	tyrosine-type recombinase/integrase	-
A6J82_RS04000 (A6J82_04020)	-	724022..725377 (+)	1356	WP_000712236.1	YjiH family protein	-
A6J82_RS04005 (A6J82_04025)	rpmH	725561..725695 (+)	135	WP_000831903.1	50S ribosomal protein L34	-
A6J82_RS04010 (A6J82_04030)	-	725930..727063 (+)	1134	WP_000564846.1	ISAs1-like element IS1548 family transposase	-
A6J82_RS04015 (A6J82_04040)	ciaR	727377..728051 (+)	675	WP_001238594.1	two-component system response regulator DltR	Regulator
A6J82_RS04020 (A6J82_04045)	dltS	728051..729238 (+)	1188	WP_000490537.1	two-component system sensor histidine kinase DltS	-
A6J82_RS04025 (A6J82_04050)	-	729249..729371 (+)	123	WP_000806141.1	teichoic acid D-Ala incorporation-associated protein DltX	-
A6J82_RS04030 (A6J82_04055)	dltA	729384..730919 (+)	1536	WP_000581010.1	D-alanine--poly(phosphoribitol) ligase subunit DltA	-
A6J82_RS04035 (A6J82_04060)	dltB	730916..732181 (+)	1266	WP_000613595.1	D-alanyl-lipoteichoic acid biosynthesis protein DltB	-
A6J82_RS04040 (A6J82_04065)	dltC	732196..732435 (+)	240	WP_000351975.1	D-alanine--poly(phosphoribitol) ligase subunit DltC	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25504.44 Da Isoelectric Point: 5.4971

                                >NTDB_id=186516 A6J82_RS04015 WP_001238594.1 727377..728051(+) (ciaR) [Streptococcus agalactiae strain FDAARGOS_254]

MRLLVVEDEKSIAEAIQALLADKGYSVDLAFDGDDGLEYILTGLYDLVLLDIMLPKRSGLSVLKRVREAGLETPIIFLTA

KSQTYDKVNGLDLGADDYITKPFEADELLARIRLRTRQSSLIRANQLRLGNIRLNTDSHELESKESSVKLSNKEFLLMEV

FMRNAKQIIPKNQLISKVWGPSDNSEYNQLEVFISFLRKKLRFLKADIEIITTKGFGYSLEERT

Nucleotide

Download Length: 675 bp

                                >NTDB_id=186516 A6J82_RS04015 WP_001238594.1 727377..728051(+) (ciaR) [Streptococcus agalactiae strain FDAARGOS_254]

ATGAGACTTCTTGTAGTTGAGGATGAAAAAAGTATAGCAGAGGCTATTCAGGCTTTATTGGCAGATAAAGGTTATTCTGT

TGATTTAGCATTTGATGGAGATGATGGGTTAGAATACATTTTGACAGGTCTCTATGATTTAGTCCTGTTGGATATTATGT

TACCCAAACGCTCAGGATTATCTGTTTTAAAAAGAGTGAGGGAAGCTGGTTTAGAAACCCCAATAATCTTTTTAACTGCA

AAATCACAGACTTATGATAAAGTTAATGGTTTAGATTTAGGGGCAGATGATTATATCACAAAACCCTTTGAAGCAGATGA

ATTGCTAGCTAGAATTAGGCTGAGAACCAGACAATCTTCTCTAATCAGAGCAAATCAATTGCGGCTTGGAAATATAAGGC

TTAACACAGATTCACATGAGCTAGAATCTAAAGAAAGTAGTGTAAAATTATCCAATAAAGAATTTCTCTTGATGGAAGTT

TTTATGCGAAATGCAAAGCAGATTATTCCTAAAAATCAGTTGATTTCTAAGGTTTGGGGACCTTCAGACAATTCAGAATA

TAACCAGTTAGAAGTATTTATTTCTTTTTTGCGAAAAAAATTGCGCTTTTTAAAAGCAGACATTGAAATAATAACCACTA

AGGGCTTTGGATATTCCTTGGAGGAGAGGACATAA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-220)

Response regulator receiver domain (Response_reg)

(4-113)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	P0A4I0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	37.838	99.107	0.375
ciaR	Streptococcus pneumoniae Rx1	37.387	99.107	0.371
ciaR	Streptococcus pneumoniae D39	37.387	99.107	0.371
ciaR	Streptococcus pneumoniae TIGR4	37.387	99.107	0.371
ciaR	Streptococcus pneumoniae R6	37.387	99.107	0.371
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366
covR	Streptococcus salivarius strain HSISS4	35.371	100	0.362

Detailed information NTG0186516