Detailed information NTG0183049

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: LLJM3_RS11860
• Genome accession: NZ_CP015901
• Coordinates: 2279998..2281221 (+)
• Length: 407 a.a.
• NCBI ID: WP_011677195.1
• Uniprot ID: A0AA34XLX6
• Organism: Lactococcus cremoris strain JM3
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2282144..2283034	2279998..2281221	flank	923

Gene organization within MGE regions

Location: 2279998..2283034

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLJM3_RS11860 (LLJM3_2425)	htrA	2279998..2281221 (+)	1224	WP_011677195.1	S1C family serine protease	Regulator
LLJM3_RS11865 (LLJM3_2426)	-	2281343..2282341 (+)	999	WP_011677196.1	glycosyltransferase family 4 protein	-

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 41564.97 Da
• Isoelectric Point: 5.7132

>NTDB_id=183049 LLJM3_RS11860 WP_011677195.1 2279998..2281221(+) (htrA) [Lactococcus cremoris strain JM3]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKQNS
QSDFSSIFGGNSGSSSANDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVL
KISSDHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIRMVDLSQLSTNDSSQLKLPSS
VTGGVVVYSVQAGHPAATAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLET
NSSSSSN

Nucleotide

• Length: 1224 bp

>NTDB_id=183049 LLJM3_RS11860 WP_011677195.1 2279998..2281221(+) (htrA) [Lactococcus cremoris strain JM3]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACCGGTGTTGTGGGTGGAGCTATCGCACTCGGAGGAAGCGCAATTTA
TCAAAGCACTACAAACCAACTAGGAAATGCTAACCGCTCAAATACAACTAGCACAAAGGTTAGTAATGTTTCGGTAAATG
TCAATACCGATGTCACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAACAGAATTCA
CAAAGTGATTTTAGTTCAATTTTTGGTGGAAATAGCGGCTCAAGTTCAGCTAATGACGGCTTGCAACTTTCCAGTGAGGG
TTCTGGTGTTATTTATAAAAAATCTGGTGGAGATGCTTACGTGGTCACTAACTATCACGTTATTGCTGGAAATAGTTCCC
TCGATGTTTTACTTTCTGGTGGGCAAAAAGTTAAAGCCACAGTTGTTGGTTATGATGAATACACTGACCTTGCCGTTCTT
AAAATCAGCTCTGACCATGTTAAAGACGTGGCAACTTTCGCTGATTCAAGCAAGTTAACTATTGGTGAACCAGCTATTGC
AGTCGGCTCACCTTTAGGTAGCCAGTTTGCTAATACTGCAACCGAAGGAATTCTGTCTGCAACAAGTCGTCAAGTCACTT
TGACTCAAGAAAATGGTCAAACAACAAGTATCAATGCGATTCAAACGGATGCTGCCATTAACCCGGGTAACTCAGGTGGA
GCCTTGATTAATATTGAAGGTCAAGTGATTGGTATTACTCAAAGTAAAATCACAACGACCGAAGATGGTTCTACCTCTGT
GGAAGGTTTAGGTTTTGCTATCCCATCTAATGATGTGGTAAACATCATTAATAAACTTGAAACTGATGGTAAGATTTCAC
GTCCTGCCTTAGGTATTCGTATGGTTGACCTATCTCAATTATCAACAAATGATAGTTCTCAACTGAAATTACCTAGCAGC
GTAACTGGTGGAGTGGTTGTCTACTCTGTTCAAGCGGGTCATCCTGCTGCCACAGCTGGTCTGAAAGCTGGCGATGTGAT
AACGAAGGTGGGAGATACCGCCGTTACTTCATCAACAGACTTACAAAGTGCTCTTTACTCACACAATATTAATGATACTG
TGAAAGTCACCTACTACCGTGATGGTAAATCAGCCACAGCAAATGTTAAACTCTCTAAATCAACAAGCGATTTAGAAACA
AATAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (250-395)

• PDZ domain (PDZ_2) (295-391)

• Trypsin-like peptidase domain (Trypsin_2) (107-252)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	55.128	95.823	0.528
htrA	Streptococcus mitis NCTC 12261	55.875	94.103	0.526
htrA	Streptococcus pneumoniae R6	58.14	84.521	0.491
htrA	Streptococcus pneumoniae TIGR4	58.14	84.521	0.491
htrA	Streptococcus pneumoniae D39	58.14	84.521	0.491
htrA	Streptococcus pneumoniae Rx1	58.14	84.521	0.491
htrA	Streptococcus mutans UA159	53.388	90.663	0.484