Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   A4265_RS08825 Genome accession   NZ_CP015238
Coordinates   1763034..1764257 (+) Length   407 a.a.
NCBI ID   WP_063632203.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NS53     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1758034..1769257
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A4265_RS08810 (A4265_08380) - 1760965..1761948 (-) 984 WP_181876658.1 IS30 family transposase -
  A4265_RS08820 (A4265_08390) rlmH 1762343..1762822 (-) 480 WP_002994924.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  A4265_RS08825 (A4265_08395) htrA 1763034..1764257 (+) 1224 WP_063632203.1 S1C family serine protease Regulator
  A4265_RS08830 (A4265_08400) spo0J 1764346..1765122 (+) 777 WP_014407987.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 407 a.a.        Molecular weight: 42759.39 Da        Isoelectric Point: 8.2489

>NTDB_id=177924 A4265_RS08825 WP_063632203.1 1763034..1764257(+) (htrA) [Streptococcus pyogenes strain NS53]
MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKNGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide


Download         Length: 1224 bp        

>NTDB_id=177924 A4265_RS08825 WP_063632203.1 1763034..1764257(+) (htrA) [Streptococcus pyogenes strain NS53]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTATTTTATTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTCAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCTCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAAATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGAATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGATTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCGCTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAGCTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGATTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(109-254)

PDZ domain (PDZ_2)

(301-396)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

61.634

99.263

0.612
  htrA Streptococcus gordonii str. Challis substr. CH1

54.975

98.771

0.543
  htrA Streptococcus mitis NCTC 12261

53.317

100

0.533
  htrA Streptococcus pneumoniae Rx1

53.071

100

0.531
  htrA Streptococcus pneumoniae D39

53.071

100

0.531
  htrA Streptococcus pneumoniae R6

53.071

100

0.531
  htrA Streptococcus pneumoniae TIGR4

53.071

100

0.531

Multiple sequence alignment