Detailed information NTG0175722

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: A3778_RS12705
• Genome accession: NZ_CP014985
• Coordinates: 2441118..2443310 (+)
• Length: 730 a.a.
• NCBI ID: WP_003585566.1
• Uniprot ID: A0A829GXH9
• Organism: Lacticaseibacillus paracasei strain IIA
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2436118..2448310

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A3778_RS12680 (A3778_11950)	-	2436175..2437095 (-)	921	WP_003574021.1	IS30 family transposase	-
A3778_RS12685 (A3778_11955)	-	2437646..2437843 (+)	198	WP_016383118.1	hypothetical protein	-
A3778_RS12690 (A3778_11960)	-	2438205..2439011 (-)	807	WP_003567351.1	LytTR family DNA-binding domain-containing protein	-
A3778_RS12695 (A3778_11965)	-	2439016..2440314 (-)	1299	WP_081528793.1	GHKL domain-containing protein	-
A3778_RS12700 (A3778_11970)	-	2440515..2440652 (+)	138	WP_003571414.1	bacteriocin-like peptide, LSEI_2386 family	-
A3778_RS12705 (A3778_11975)	comA	2441118..2443310 (+)	2193	WP_003585566.1	peptide cleavage/export ABC transporter	Regulator
A3778_RS12710 (A3778_11980)	-	2443321..2444700 (+)	1380	WP_003585563.1	bacteriocin secretion accessory protein	-
A3778_RS12715 (A3778_11985)	-	2444874..2445224 (+)	351	WP_003567340.1	hypothetical protein	-
A3778_RS12720 (A3778_11990)	-	2445297..2445608 (+)	312	WP_191982453.1	hypothetical protein	-
A3778_RS12725 (A3778_11995)	-	2445914..2447269 (+)	1356	WP_003567335.1	threonine/serine exporter ThrE family protein	-
A3778_RS12730 (A3778_12000)	-	2447371..2447667 (+)	297	WP_003580847.1	bacteriocin immunity protein	-
A3778_RS12735 (A3778_12005)	-	2447860..2448144 (+)	285	WP_003580845.1	bacteriocin immunity protein	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81282.51 Da
• Isoelectric Point: 7.0227

>NTDB_id=175722 A3778_RS12705 WP_003585566.1 2441118..2443310(+) (comA) [Lacticaseibacillus paracasei strain IIA]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDPSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPILARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=175722 A3778_RS12705 WP_003585566.1 2441118..2443310(+) (comA) [Lacticaseibacillus paracasei strain IIA]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGTTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTGGCGAAGA
CGGATCAGGAAGGGACGACGGCATTAGGGATTGTCCGCGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCGGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTGGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATCCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATACTAGCGCGACAAAAAGGGATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATTACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTTGCTTATGTCCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAGCGTTTGTCGATTGATGTCATTTTGGGTTACGTTAGGCATCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAGATTGTATCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACAATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATATTGAGTTCATCCATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCTATCAACGTGACCGATGTGTCTTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGAGAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGGGTTCCCATC
AGTGATGTTGATCTGACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGATCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (510-662)

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

3D structure

• AlphaFold DB: A0A829GXH9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	59.053	98.356	0.581
comA	Streptococcus pneumoniae Rx1	58.496	98.356	0.575
comA	Streptococcus pneumoniae D39	58.496	98.356	0.575
comA	Streptococcus pneumoniae R6	58.496	98.356	0.575
comA	Streptococcus mitis SK321	58.357	98.356	0.574
comA	Streptococcus pneumoniae TIGR4	58.078	98.356	0.571
comA	Streptococcus gordonii str. Challis substr. CH1	57.103	98.356	0.562
comA/nlmT	Streptococcus mutans UA159	54.986	98.904	0.544