Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   A0O21_RS08660 Genome accession   NZ_CP014699
Coordinates   1874253..1876403 (-) Length   716 a.a.
NCBI ID   WP_067065258.1    Uniprot ID   A0A172QAM4
Organism   Streptococcus pantholopis strain TA 26     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1869253..1881403
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A0O21_RS08635 (A0O21_08635) - 1869629..1870261 (-) 633 WP_067064310.1 thiamine diphosphokinase -
  A0O21_RS08640 (A0O21_08640) rpe 1870254..1870919 (-) 666 WP_067064313.1 ribulose-phosphate 3-epimerase -
  A0O21_RS08645 (A0O21_08645) rsgA 1870928..1871800 (-) 873 WP_067064315.1 ribosome small subunit-dependent GTPase A -
  A0O21_RS08650 (A0O21_08650) - 1872018..1872671 (-) 654 WP_067064317.1 NAD(P)H-binding protein -
  A0O21_RS08655 (A0O21_08655) - 1872882..1874243 (-) 1362 WP_067064319.1 bacteriocin secretion accessory protein -
  A0O21_RS08660 (A0O21_08660) comA 1874253..1876403 (-) 2151 WP_067065258.1 peptide cleavage/export ABC transporter ComA Regulator
  A0O21_RS08670 (A0O21_08670) - 1877067..1877207 (-) 141 WP_067064323.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  A0O21_RS08675 (A0O21_08675) - 1877219..1877407 (-) 189 WP_067064325.1 hypothetical protein -
  A0O21_RS08680 (A0O21_08680) - 1877426..1877602 (-) 177 WP_067064327.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  A0O21_RS08685 (A0O21_08685) - 1877744..1877932 (-) 189 WP_067064329.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  A0O21_RS10675 - 1878934..1879104 (-) 171 WP_082854440.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  A0O21_RS08690 (A0O21_08690) - 1879134..1879325 (-) 192 WP_067064331.1 hypothetical protein -
  A0O21_RS08695 (A0O21_08695) - 1879352..1879531 (-) 180 WP_227806866.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  A0O21_RS08700 (A0O21_08700) - 1879947..1880837 (-) 891 WP_067064333.1 helix-turn-helix domain-containing protein -
  A0O21_RS11095 - 1881200..1881331 (+) 132 WP_257722076.1 hypothetical protein -

Sequence

Protein


Download         Length: 716 a.a.        Molecular weight: 80510.53 Da        Isoelectric Point: 7.5976

>NTDB_id=173372 A0O21_RS08660 WP_067065258.1 1874253..1876403(-) (comA) [Streptococcus pantholopis strain TA 26]
MKFKKKHYRAQVDTRDCGVAALAMIFDFYGSYYSLATLRELAQTTQEGTTAFGLVKVAEGEGFETRAFRADMSLFDEDII
YPFIAHVLKNGNLMHYYVVTGCDKKTIHIADPDPSVRLTKIPRERFEKEWTGTAIFIAPAPSYKVHKEQKDSLLSFIPLL
ARQKGLIVNIVVATFLVTIINIVGSYYLQSIIDTYIPQQIKNTLSIISFGLIIVYLLQQLIAYAQEYLLLVLGQRLSIDV
ILSYIKHIFHLPMSFFATRRTGEIISRFTDANSIIDALASTILSIFLDVSTVIIVSIVLFSQNSNLFFISLLALPIYTII
IFSFMKPFERMNQESMEANAVLSSSIIEDINGIETIKSLTSEKQRYQKIDREFVTYLKKSFAYGKAESAQKILKKLAQLL
LNVGVLWLGANLVMDNKMTLGQLITYNTLLVYFTNPLENLINLQTKLQTAKVANNRLNEVYLVKSEFEDKKTVHDINNFS
GNITLKDVSYSYGYGQEVLSEIKLTIKAGSKLSFVGISGSGKTTLAKMLVNFYSPTKGEILLDGVNFNEIDKESLRRYIN
YLPQKPYVFNGTILDNLLLGAKEGTSQEDIFRAVQLAEIKSDIEAMPLSYQTELTTDGVGISGGQGQRIALARALLTDSP
ILILDEATSSLDVLTEKKILDNLMALDKTLIFIAHRLTISERTEHIVVLDKGKIIEEGNHKELLQKQGFYAHLVNS

Nucleotide


Download         Length: 2151 bp        

>NTDB_id=173372 A0O21_RS08660 WP_067065258.1 1874253..1876403(-) (comA) [Streptococcus pantholopis strain TA 26]
ATGAAATTTAAGAAAAAACATTATCGTGCTCAAGTTGATACAAGAGACTGTGGTGTGGCGGCTTTAGCAATGATTTTTGA
TTTTTATGGCTCCTACTATTCTTTAGCAACCTTACGAGAGCTTGCACAAACTACCCAAGAGGGAACAACAGCCTTTGGTT
TAGTAAAAGTTGCCGAAGGAGAGGGGTTTGAGACCCGTGCTTTTCGTGCTGATATGTCTCTCTTTGATGAGGATATCATC
TATCCATTTATAGCTCATGTGCTTAAAAATGGTAATTTGATGCACTATTATGTCGTTACAGGGTGTGATAAAAAGACTAT
TCACATTGCTGACCCTGACCCTAGTGTAAGATTAACTAAAATACCACGAGAACGTTTTGAAAAAGAGTGGACGGGAACAG
CGATATTTATAGCACCAGCACCTAGTTATAAAGTTCATAAAGAACAAAAAGATAGTTTGCTATCATTTATTCCGCTTTTA
GCTCGCCAAAAGGGATTGATAGTTAATATTGTGGTGGCAACATTCTTAGTGACAATAATAAATATTGTCGGTTCTTATTA
CCTTCAATCTATAATTGATACTTATATTCCACAACAGATTAAAAATACACTTAGCATAATTTCTTTTGGCTTAATTATTG
TTTACTTACTACAGCAACTAATCGCTTACGCACAAGAATACCTCTTATTGGTACTTGGTCAACGTTTATCTATTGATGTC
ATTTTATCTTATATCAAACATATTTTTCATTTACCAATGTCCTTTTTTGCTACCAGAAGAACAGGGGAAATTATATCACG
TTTTACTGATGCTAACTCCATTATCGATGCACTTGCAAGTACCATCCTTTCAATCTTTTTAGATGTTTCTACTGTCATTA
TTGTTTCAATCGTTCTATTTTCACAAAATAGCAACTTATTCTTTATCAGCTTATTAGCTTTACCTATTTATACGATTATC
ATTTTTTCTTTTATGAAACCATTCGAACGTATGAATCAGGAATCTATGGAAGCTAATGCGGTATTATCATCATCCATTAT
TGAAGATATTAATGGTATCGAAACAATCAAATCTTTAACAAGTGAAAAACAACGTTACCAAAAAATCGATAGAGAGTTTG
TCACTTATCTAAAAAAATCATTTGCTTATGGCAAAGCAGAAAGTGCGCAAAAGATACTCAAAAAATTAGCTCAATTATTA
CTAAATGTTGGGGTCCTTTGGCTTGGAGCAAACTTGGTGATGGATAATAAAATGACTTTAGGACAGCTTATTACCTATAA
TACTTTATTAGTCTATTTTACTAATCCGTTGGAAAACCTAATTAATCTTCAAACAAAACTCCAAACAGCTAAGGTTGCTA
ATAATCGTTTAAATGAAGTTTATTTAGTTAAGTCAGAATTTGAAGATAAGAAAACAGTTCATGATATAAATAATTTTAGT
GGTAATATCACTCTTAAAGATGTTAGCTATAGCTATGGTTATGGACAAGAAGTTCTTTCAGAGATCAAATTAACAATCAA
GGCTGGTAGCAAATTATCATTTGTTGGTATTTCAGGGTCAGGAAAGACAACTCTAGCTAAAATGTTAGTTAATTTTTATA
GTCCAACTAAGGGAGAAATTCTTTTAGATGGTGTTAATTTCAATGAAATTGATAAAGAAAGTTTACGTCGATATATTAAT
TACTTGCCACAAAAACCTTATGTATTTAACGGTACTATTCTTGATAATTTGTTGTTAGGCGCTAAAGAAGGTACAAGCCA
AGAAGATATTTTTAGGGCTGTTCAGTTAGCTGAAATAAAATCAGATATTGAAGCTATGCCGCTTAGTTATCAAACAGAAT
TAACAACGGATGGAGTAGGAATTTCTGGAGGACAAGGTCAGCGTATTGCTCTTGCAAGAGCATTGCTGACTGATTCTCCG
ATACTTATTTTGGACGAAGCAACAAGCAGTTTAGATGTTCTTACGGAAAAGAAAATTCTTGATAATTTAATGGCTTTAGA
TAAAACATTGATCTTTATAGCGCATCGATTAACAATTTCTGAAAGAACAGAGCATATTGTTGTTCTTGATAAAGGAAAAA
TTATTGAAGAGGGAAATCATAAAGAATTACTGCAGAAGCAAGGTTTTTATGCTCACTTAGTAAACAGTTAG

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(499-649)

ABC transporter transmembrane region (ABC_membrane)

(169-437)

Peptidase C39 family (Peptidase_C39)

(6-141)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A172QAM4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

78.382

100

0.785
  comA Streptococcus mitis SK321

77.964

100

0.781
  comA Streptococcus pneumoniae Rx1

77.824

100

0.779
  comA Streptococcus pneumoniae D39

77.824

100

0.779
  comA Streptococcus pneumoniae R6

77.824

100

0.779
  comA Streptococcus pneumoniae TIGR4

77.406

100

0.775
  comA Streptococcus gordonii str. Challis substr. CH1

76.43

100

0.765
  comA/nlmT Streptococcus mutans UA159

62.483

100

0.626

Multiple sequence alignment