Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   A0O21_RS07665 Genome accession   NZ_CP014699
Coordinates   1653469..1654224 (-) Length   251 a.a.
NCBI ID   WP_067063844.1    Uniprot ID   A0A172Q8S8
Organism   Streptococcus pantholopis strain TA 26     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1648469..1659224
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A0O21_RS07645 (A0O21_07645) - 1648643..1649869 (-) 1227 WP_067063829.1 cysteine desulfurase -
  A0O21_RS07650 (A0O21_07650) sufD 1649957..1651219 (-) 1263 WP_067063833.1 Fe-S cluster assembly protein SufD -
  A0O21_RS07655 (A0O21_07655) sufC 1651259..1652029 (-) 771 WP_067063837.1 Fe-S cluster assembly ATPase SufC -
  A0O21_RS07660 (A0O21_07660) - 1652289..1653467 (-) 1179 WP_067063840.1 glycosyltransferase family 4 protein -
  A0O21_RS07665 (A0O21_07665) mecA 1653469..1654224 (-) 756 WP_067063844.1 adaptor protein MecA Regulator
  A0O21_RS07670 (A0O21_07670) - 1654494..1655438 (-) 945 WP_067063847.1 hypothetical protein -
  A0O21_RS07675 (A0O21_07675) - 1655451..1656815 (-) 1365 WP_067063851.1 PTS transporter subunit EIIC -
  A0O21_RS07680 (A0O21_07680) rpiB 1656818..1657273 (-) 456 WP_067063854.1 ribose 5-phosphate isomerase B -
  A0O21_RS07685 (A0O21_07685) rpe 1657270..1657926 (-) 657 WP_067063857.1 ribulose-phosphate 3-epimerase -
  A0O21_RS07690 (A0O21_07690) - 1658143..1659153 (+) 1011 WP_067063860.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 251 a.a.        Molecular weight: 28997.60 Da        Isoelectric Point: 4.1711

>NTDB_id=173369 A0O21_RS07665 WP_067063844.1 1653469..1654224(-) (mecA) [Streptococcus pantholopis strain TA 26]
MEMKQISETTLKITISMDDLEEHGMELKDFLIPQEKTEEFFYTIMDELDLPDNFKDTGMLSFRVTPRKDQIDVFVTKSDL
NKDINFEDLAEFGDVSQMTPEDFFKTLEKSMREKGDTEAHEKLEKIEEMMEQTADSVLNESKAGERDAGEQEPGDYIHYV
LDFPSLEAAVAFSKTVDFDIEASEFYKEGETYHLAVLLNLVHKPSYYANLVHARLLEHAWQGTKTRAYLQEHGVELLMAD
AVQQLQMIELV

Nucleotide


Download         Length: 756 bp        

>NTDB_id=173369 A0O21_RS07665 WP_067063844.1 1653469..1654224(-) (mecA) [Streptococcus pantholopis strain TA 26]
ATGGAAATGAAACAGATAAGTGAGACAACCTTAAAAATCACCATCAGTATGGACGATTTAGAAGAACACGGAATGGAATT
AAAAGATTTTTTGATTCCTCAGGAAAAGACAGAAGAGTTTTTCTATACGATTATGGATGAACTGGATTTACCGGATAACT
TTAAGGATACGGGTATGCTGAGCTTTCGCGTGACTCCGCGAAAAGATCAGATTGATGTTTTTGTTACTAAATCAGATTTA
AACAAAGATATTAATTTCGAAGATTTGGCAGAATTCGGGGATGTATCGCAGATGACGCCGGAAGATTTTTTCAAAACTTT
AGAGAAGTCAATGCGGGAAAAAGGGGACACTGAAGCCCATGAAAAGTTGGAAAAGATTGAAGAGATGATGGAGCAGACTG
CGGATTCAGTTCTAAACGAAAGCAAAGCAGGCGAAAGGGATGCCGGAGAACAGGAACCGGGGGACTATATTCACTATGTG
CTCGACTTTCCGAGTTTGGAAGCTGCTGTTGCCTTTTCAAAAACAGTTGACTTTGATATTGAAGCGTCTGAATTTTATAA
AGAAGGGGAGACCTATCACTTAGCTGTTCTTCTTAATCTGGTCCATAAACCCAGCTATTACGCTAATTTGGTGCATGCCC
GCCTGCTGGAGCATGCCTGGCAGGGGACTAAAACACGGGCTTATCTGCAGGAGCATGGAGTGGAACTGTTAATGGCTGAT
GCGGTTCAGCAGCTGCAAATGATTGAGTTGGTATAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A172Q8S8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

66.129

98.805

0.653
  mecA Streptococcus thermophilus LMD-9

55.87

98.406

0.55
  mecA Streptococcus thermophilus LMG 18311

55.061

98.406

0.542
  mecA Streptococcus pneumoniae Rx1

49.012

100

0.494
  mecA Streptococcus pneumoniae D39

49.012

100

0.494
  mecA Streptococcus pneumoniae R6

49.012

100

0.494
  mecA Streptococcus pneumoniae TIGR4

49.012

100

0.494

Multiple sequence alignment