Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   EfmE745_RS01225 Genome accession   NZ_CP014529
Coordinates   247998..249281 (-) Length   427 a.a.
NCBI ID   WP_002324312.1    Uniprot ID   A0AB37VT26
Organism   Enterococcus faecium strain E745     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 242998..254281
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EfmE745_RS01195 (EfmE745_00249) - 243157..244113 (-) 957 WP_002317103.1 glycosyltransferase family 2 protein -
  EfmE745_RS01200 (EfmE745_00250) - 244285..244638 (-) 354 WP_002317104.1 PepSY domain-containing protein -
  EfmE745_RS01205 (EfmE745_00251) pepA 244837..245916 (+) 1080 WP_002317105.1 glutamyl aminopeptidase -
  EfmE745_RS01210 (EfmE745_00252) - 246208..246528 (+) 321 WP_002317106.1 thioredoxin family protein -
  EfmE745_RS01215 (EfmE745_00253) - 246558..247025 (+) 468 WP_002317107.1 universal stress protein -
  EfmE745_RS01220 (EfmE745_00254) ytpR 247335..247940 (+) 606 WP_002317108.1 YtpR family tRNA-binding protein -
  EfmE745_RS01225 (EfmE745_00255) htrA 247998..249281 (-) 1284 WP_002324312.1 S1C family serine protease Regulator
  EfmE745_RS01230 (EfmE745_00256) rlmH 249734..250213 (+) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EfmE745_RS01245 (EfmE745_00259) - 251961..253091 (+) 1131 WP_002317111.1 hypothetical protein -
  EfmE745_RS01250 (EfmE745_00260) - 253259..254167 (+) 909 WP_010778368.1 IS982-like element ISEfm1 family transposase -

Sequence

Protein


Download         Length: 427 a.a.        Molecular weight: 44453.55 Da        Isoelectric Point: 4.7976

>NTDB_id=172128 EfmE745_RS01225 WP_002324312.1 247998..249281(-) (htrA) [Enterococcus faecium strain E745]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTKV
KAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVNI
NAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITMV
DLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYRG
KEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1284 bp        

>NTDB_id=172128 EfmE745_RS01225 WP_002324312.1 247998..249281(-) (htrA) [Enterococcus faecium strain E745]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATCACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGTCAACTATTTGGCCA
ACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTAATT
CCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAAGTC
AAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGTTGC
TTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATGCCA
ACTCTGTGACTTCGGGGATCATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAATATC
AATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGACAAGTGATCGG
GATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCCCAA
GTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATGGTT
GACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGTTAC
TAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTGATG
TTTCTTCTGGTGTAGAATTACAATCTGTCTTATATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGCGGA
AAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGTCAATCAGAGAACTCTGGTAA
CTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(123-268)

PDZ domain (PDZ_2)

(313-410)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.483

94.145

0.504
  htrA Streptococcus mutans UA159

54.177

92.506

0.501
  htrA Streptococcus pneumoniae D39

58.631

78.689

0.461
  htrA Streptococcus pneumoniae TIGR4

58.631

78.689

0.461
  htrA Streptococcus pneumoniae R6

58.631

78.689

0.461
  htrA Streptococcus pneumoniae Rx1

58.631

78.689

0.461
  htrA Streptococcus mitis NCTC 12261

57.738

78.689

0.454

Multiple sequence alignment