Detailed information
Bioinformatically predicted
Overview
| Name | pepF | Type | Regulator |
| Locus tag | MGAS23530_RS05135 | Genome accession | NZ_CP013839 |
| Coordinates | 1054485..1056290 (-) | Length | 601 a.a. |
| NCBI ID | WP_011054652.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain MGAS23530 | ||
| Function | degradation of XIP; competence shut-off (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1034255..1081304 | 1054485..1056290 | within | 0 |
Gene organization within MGE regions
Location: 1034255..1081304
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MGAS23530_RS05045 (MGAS23530_1038) | - | 1034293..1035567 (-) | 1275 | WP_020837316.1 | polysaccharide deacetylase family protein | - |
| MGAS23530_RS05050 (MGAS23530_1039) | - | 1035662..1037089 (-) | 1428 | WP_011284931.1 | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | - |
| MGAS23530_RS05055 (MGAS23530_1040) | ptsP | 1037274..1039007 (-) | 1734 | WP_002984033.1 | phosphoenolpyruvate--protein phosphotransferase | - |
| MGAS23530_RS05060 (MGAS23530_1041) | - | 1039012..1039275 (-) | 264 | WP_002984031.1 | phosphocarrier protein HPr | - |
| MGAS23530_RS05065 (MGAS23530_1042) | - | 1039668..1039886 (+) | 219 | WP_002989242.1 | redoxin NrdH | - |
| MGAS23530_RS05070 (MGAS23530_1043) | nrdE | 1039906..1042065 (+) | 2160 | WP_031488773.1 | class 1b ribonucleoside-diphosphate reductase subunit alpha | - |
| MGAS23530_RS05075 (MGAS23530_1045) | nrdF | 1042398..1043357 (+) | 960 | WP_002987365.1 | class 1b ribonucleoside-diphosphate reductase subunit beta | - |
| MGAS23530_RS05080 (MGAS23530_1046) | - | 1043419..1044645 (+) | 1227 | WP_021340858.1 | chloride channel protein | - |
| MGAS23530_RS08640 (MGAS23530_1047) | - | 1044741..1045898 (+) | 1158 | Protein_985 | IS3 family transposase | - |
| MGAS23530_RS05100 (MGAS23530_1048) | - | 1045990..1046685 (-) | 696 | WP_031488553.1 | CPBP family intramembrane glutamic endopeptidase | - |
| MGAS23530_RS05105 (MGAS23530_1049) | - | 1046704..1047465 (-) | 762 | WP_031488552.1 | DUF3169 family protein | - |
| MGAS23530_RS05110 (MGAS23530_1050) | - | 1047462..1047677 (-) | 216 | WP_002989220.1 | helix-turn-helix transcriptional regulator | - |
| MGAS23530_RS05115 (MGAS23530_1052) | alaS | 1048017..1050635 (-) | 2619 | WP_031488551.1 | alanine--tRNA ligase | - |
| MGAS23530_RS05120 (MGAS23530_1053) | prsA | 1051022..1052077 (-) | 1056 | WP_002984003.1 | peptidylprolyl isomerase PrsA | - |
| MGAS23530_RS05125 (MGAS23530_1054) | - | 1052140..1052847 (-) | 708 | WP_002984000.1 | O-methyltransferase | - |
| MGAS23530_RS05130 (MGAS23530_1055) | - | 1052913..1054109 (-) | 1197 | WP_002995765.1 | OFA family MFS transporter | - |
| MGAS23530_RS05135 (MGAS23530_1056) | pepF | 1054485..1056290 (-) | 1806 | WP_011054652.1 | oligoendopeptidase F | Regulator |
| MGAS23530_RS05140 (MGAS23530_1057) | - | 1056303..1057265 (-) | 963 | WP_053039058.1 | competence protein CoiA | - |
| MGAS23530_RS05145 (MGAS23530_1058) | - | 1057561..1058277 (-) | 717 | WP_002995774.1 | pseudouridine synthase | - |
| MGAS23530_RS05150 (MGAS23530_1059) | nagB | 1058396..1059100 (-) | 705 | WP_002995779.1 | glucosamine-6-phosphate deaminase | - |
| MGAS23530_RS05155 (MGAS23530_1060) | queA | 1059302..1060330 (+) | 1029 | WP_031488549.1 | tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA | - |
| MGAS23530_RS05160 (MGAS23530_1061) | - | 1060337..1061557 (+) | 1221 | WP_002983986.1 | DUF3114 domain-containing protein | - |
| MGAS23530_RS05165 (MGAS23530_1062) | - | 1061691..1062281 (-) | 591 | WP_002983984.1 | serine hydrolase | - |
| MGAS23530_RS08910 (MGAS23530_1063) | - | 1062278..1062505 (-) | 228 | WP_226316535.1 | hypothetical protein | - |
| MGAS23530_RS05175 (MGAS23530_1064) | - | 1062506..1062739 (-) | 234 | WP_002983979.1 | hypothetical protein | - |
| MGAS23530_RS05180 (MGAS23530_1065) | sodA | 1062906..1063511 (-) | 606 | WP_002983977.1 | superoxide dismutase SodA | - |
| MGAS23530_RS05185 (MGAS23530_1066) | holA | 1063608..1064648 (-) | 1041 | WP_031488548.1 | DNA polymerase III subunit delta | - |
| MGAS23530_RS05190 (MGAS23530_1067) | - | 1064719..1066962 (-) | 2244 | WP_031488547.1 | DNA internalization-related competence protein ComEC/Rec2 | - |
| MGAS23530_RS05195 (MGAS23530_1068) | - | 1066943..1067605 (-) | 663 | WP_002983967.1 | ComEA family DNA-binding protein | - |
| MGAS23530_RS05200 (MGAS23530_1070) | - | 1067805..1068545 (-) | 741 | WP_031488546.1 | lysophospholipid acyltransferase family protein | - |
| MGAS23530_RS05205 (MGAS23530_1069) | - | 1068663..1069439 (+) | 777 | WP_010922438.1 | tRNA1(Val) (adenine(37)-N6)-methyltransferase | - |
| MGAS23530_RS05210 (MGAS23530_1071) | - | 1069429..1069707 (+) | 279 | WP_011017953.1 | GIY-YIG nuclease family protein | - |
| MGAS23530_RS05215 (MGAS23530_1072) | - | 1069731..1071731 (-) | 2001 | WP_053039059.1 | potassium transporter Kup | - |
| MGAS23530_RS05220 (MGAS23530_1073) | - | 1071858..1073477 (-) | 1620 | WP_002989158.1 | DEAD/DEAH box helicase | - |
| MGAS23530_RS05225 (MGAS23530_1075) | - | 1073784..1075328 (-) | 1545 | WP_031488544.1 | peptide chain release factor 3 | - |
| MGAS23530_RS05230 (MGAS23530_1076) | - | 1075576..1076271 (-) | 696 | WP_031488543.1 | TIGR02206 family membrane protein | - |
| MGAS23530_RS05235 (MGAS23530_1077) | - | 1076351..1077742 (-) | 1392 | WP_031488542.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| MGAS23530_RS05240 (MGAS23530_1078) | - | 1077933..1078979 (-) | 1047 | WP_002989146.1 | D-alanine--D-alanine ligase | - |
| MGAS23530_RS05245 (MGAS23530_1079) | recR | 1079080..1079676 (-) | 597 | WP_002983939.1 | recombination mediator RecR | - |
| MGAS23530_RS09015 | - | 1079723..1079914 (-) | 192 | WP_002983936.1 | hypothetical protein | - |
| MGAS23530_RS05255 (MGAS23530_1080) | - | 1080473..1081252 (-) | 780 | WP_014407680.1 | formate/nitrite transporter family protein | - |
Sequence
Protein
Download Length: 601 a.a. Molecular weight: 69341.19 Da Isoelectric Point: 4.7093
>NTDB_id=165073 MGAS23530_RS05135 WP_011054652.1 1054485..1056290(-) (pepF) [Streptococcus pyogenes strain MGAS23530]
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
MTDNRSHLEEKYTWDLSTIFATDKDWEAEVSDLATEIDAAKDFSGHLLDSSANLLTITDTYLELARRVEKVYVYAHMKND
QDTTVAKYQEYQAKASGLYAKFSEVFSFYDPEVMALSQEDYQAFLAETPDLKRYHHFFDKLFQTRDHVLSQAEEELLAGA
QEIFNGAEETFSILDNADIVFPVVKNDKGEDVELTHGNFISLMESKDRSIRQAAYEAMYSTYEQFQHTYAKTLQTNVKVQ
NYKARVHKYDSARQAAMAANFIPEAVYDTLLETVNKHLPLLHRYLKLRQEVLGLDDLKMYDVYTPLSETDLAIGYDEALE
KAEKVLAVFGKDYADRVHRAFTERWIDVHVNKGKRSGAYSGGSYDTNAFMLLNWQDTLDNLYTLVHETGHSLHSTFTRET
QPYVYGDYSIFLAEIASTTNENIMTEALLNEVQDEKERFAILNHYLDGFRGTVFRQTQFAEFEHAIHQADQKGEVLTSEY
LNQLYADLNEKYYGLSKKDNHFIQYEWARIPHFYYNYYVYQYATGFAAASYLADKIVHGTQDDIDHYLAYLKSGNSDYPL
EVIAKAGVDMAKGDYLEAAFKVFDERLTELEVLVSKGIHKS
Nucleotide
Download Length: 1806 bp
>NTDB_id=165073 MGAS23530_RS05135 WP_011054652.1 1054485..1056290(-) (pepF) [Streptococcus pyogenes strain MGAS23530]
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
ATGACTGATAATCGCAGCCATTTAGAAGAAAAATACACTTGGGATTTGAGCACTATTTTTGCAACAGATAAGGATTGGGA
AGCTGAAGTCAGTGACTTAGCTACTGAAATTGACGCGGCTAAGGATTTTTCAGGTCATTTACTAGATTCTAGCGCTAATC
TGTTGACAATTACAGATACTTATTTAGAGTTAGCTCGTCGTGTTGAGAAAGTCTATGTTTATGCTCACATGAAAAATGAC
CAAGACACTACTGTTGCCAAGTATCAAGAATACCAAGCTAAGGCTTCAGGCTTGTATGCAAAGTTTAGCGAAGTGTTTTC
ATTCTATGACCCAGAAGTTATGGCATTGAGTCAGGAAGATTACCAAGCTTTTCTTGCGGAAACACCTGATTTAAAAAGGT
ATCATCATTTCTTTGACAAATTGTTCCAGACACGTGACCATGTGCTCAGCCAGGCTGAAGAGGAATTATTAGCAGGAGCC
CAAGAAATTTTCAACGGCGCTGAAGAAACCTTTAGTATTCTTGATAACGCTGATATTGTCTTTCCAGTAGTTAAAAATGA
TAAGGGGGAAGATGTTGAATTAACCCATGGTAACTTCATTAGCCTAATGGAATCTAAGGACCGTAGCATTCGCCAAGCTG
CTTATGAAGCCATGTATAGTACTTATGAACAGTTCCAACATACTTACGCTAAAACCTTGCAAACCAATGTGAAAGTGCAA
AACTATAAGGCGCGTGTTCATAAATACGATTCAGCACGTCAAGCTGCCATGGCTGCTAACTTTATTCCAGAAGCTGTTTA
CGATACCTTGTTAGAAACGGTTAATAAACATTTGCCACTCTTACACCGTTATTTGAAATTGCGTCAAGAGGTTCTTGGTT
TAGACGATTTGAAGATGTATGATGTTTACACACCATTATCTGAAACAGATTTAGCCATTGGTTATGATGAGGCTTTGGAA
AAGGCTGAGAAGGTTTTGGCTGTTTTTGGTAAGGATTACGCGGATCGTGTACATCGTGCTTTTACCGAACGTTGGATTGA
TGTTCACGTCAATAAAGGGAAGCGCTCTGGGGCTTATTCAGGTGGTTCCTATGATACCAATGCCTTCATGCTGTTGAACT
GGCAAGATACACTTGATAATCTTTACACACTTGTCCACGAAACAGGCCACAGTTTGCATTCTACTTTCACTCGTGAAACA
CAGCCTTATGTGTATGGGGATTATAGTATCTTCTTGGCAGAAATTGCATCCACAACGAATGAAAACATCATGACAGAAGC
TCTCTTAAATGAAGTGCAAGATGAGAAAGAACGCTTTGCCATTTTAAACCATTACCTCGATGGTTTCCGTGGAACAGTTT
TCCGTCAAACCCAATTTGCTGAGTTTGAACATGCCATTCATCAAGCTGATCAAAAAGGAGAAGTGTTAACAAGTGAATAC
CTTAACCAGCTATACGCTGATTTAAATGAAAAATATTATGGTTTAAGTAAAAAAGATAATCATTTTATTCAGTATGAATG
GGCACGTATTCCTCATTTCTATTACAATTATTATGTTTACCAATATGCAACAGGGTTTGCAGCTGCAAGCTATTTAGCGG
ATAAGATTGTGCATGGCACACAAGATGATATCGATCATTACTTGGCCTACCTCAAGTCAGGAAATTCTGATTACCCACTT
GAAGTGATTGCTAAAGCAGGCGTTGATATGGCAAAAGGTGATTATTTGGAAGCTGCCTTTAAAGTCTTTGACGAACGTCT
AACAGAACTTGAAGTACTCGTGTCCAAAGGCATACACAAAAGCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| pepF | Streptococcus salivarius strain HSISS4 |
71.215 |
100 |
0.712 |