Detailed information NTG0164988

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: MGAS11027_RS00260
• Genome accession: NZ_CP013838
• Coordinates: 47107..48018 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS11027
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42107..53018

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS11027_RS00240 (MGAS11027_0051)	purE	42694..43185 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MGAS11027_RS00245 (MGAS11027_0052)	purK	43172..44245 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MGAS11027_RS00250 (MGAS11027_0053)	-	44247..45665 (+)	1419	WP_023612101.1	hypothetical protein	-
MGAS11027_RS00255 (MGAS11027_0054)	purB	45685..46977 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
MGAS11027_RS00260 (MGAS11027_0055)	comR	47107..48018 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
MGAS11027_RS09625 (MGAS11027_0056)	comS	48102..48197 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
MGAS11027_RS00265 (MGAS11027_0057)	ruvB	48244..49242 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
MGAS11027_RS00270 (MGAS11027_0058)	-	49380..49817 (+)	438	WP_020904819.1	low molecular weight protein-tyrosine-phosphatase	-
MGAS11027_RS00275 (MGAS11027_0059)	-	49841..50242 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
MGAS11027_RS00280 (MGAS11027_0060)	-	50239..52014 (+)	1776	WP_014407199.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=164988 MGAS11027_RS00260 WP_002986681.1 47107..48018(+) (comR) [Streptococcus pyogenes strain MGAS11027]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=164988 MGAS11027_RS00260 WP_002986681.1 47107..48018(+) (comR) [Streptococcus pyogenes strain MGAS11027]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAGGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462