Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   AUC63_RS00770 Genome accession   NZ_CP013726
Coordinates   163498..164760 (-) Length   420 a.a.
NCBI ID   WP_029237456.1    Uniprot ID   A0A1X4JLK3
Organism   Weissella cibaria strain CMS2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 158498..169760
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AUC63_RS00745 (AUC63_00152) pnuC 158699..159496 (-) 798 WP_010372047.1 nicotinamide riboside transporter PnuC -
  AUC63_RS00750 (AUC63_00153) rpoE 159702..160295 (-) 594 WP_010372050.1 DNA-directed RNA polymerase subunit delta -
  AUC63_RS00755 (AUC63_00154) yidA 160376..161212 (-) 837 WP_010372054.1 sugar-phosphatase -
  AUC63_RS00760 (AUC63_00155) - 161258..162616 (-) 1359 WP_010372056.1 HD domain-containing protein -
  AUC63_RS00765 (AUC63_00156) - 162722..163159 (+) 438 WP_010372059.1 DUF1934 domain-containing protein -
  AUC63_RS00770 (AUC63_00157) htrA 163498..164760 (-) 1263 WP_029237456.1 S1C family serine protease Regulator
  AUC63_RS00775 (AUC63_00158) - 164875..165684 (-) 810 WP_038228981.1 MBL fold metallo-hydrolase -
  AUC63_RS00780 (AUC63_00159) - 165777..166589 (-) 813 WP_010372067.1 two-component system regulatory protein YycI -
  AUC63_RS00785 (AUC63_00160) yycH 166589..167914 (-) 1326 WP_010372070.1 two-component system activity regulator YycH -

Sequence

Protein


Download         Length: 420 a.a.        Molecular weight: 42751.56 Da        Isoelectric Point: 4.9746

>NTDB_id=164423 AUC63_RS00770 WP_029237456.1 163498..164760(-) (htrA) [Weissella cibaria strain CMS2]
MKKTSTTKIAIIGIVAGLVGGGAAAGGVTYLNNAGTFSTVTTGKTTPVKVSNSNVKGESDATKAFNKVSGAVVSVINLQK
QQSLSDSGSLFGGLFGGDESSSSDSKSTDSSDLQTASEGSGVVYKKDGNTAYIVTNNHVVSGSNALQVLLSDGTKLTATL
VGTDEQTDLAVLKINASKVSEVADFANSSKIEPGQSVLAIGSPLGSEYATSVTEGIISATKREVDATNENGDSLGKATVI
QTDAAINPGNSGGPLVNLAGQVVGINSMKLASSTDGTSVEGMGFAIPANTVVNIINELEKNGKVERPALGVSMVDLSNVS
TTDQSTILKLPTSVSGGVVVISTEDGSAAATAGLKKYDVITKIDDTEVTGSGDLRDALYKHKVGDTIKVTYYRDGKQKTT
DVKLTKTTSSLSTKSEANQN

Nucleotide


Download         Length: 1263 bp        

>NTDB_id=164423 AUC63_RS00770 WP_029237456.1 163498..164760(-) (htrA) [Weissella cibaria strain CMS2]
ATGAAAAAGACATCAACCACAAAAATAGCAATTATCGGGATTGTTGCCGGGCTAGTCGGCGGTGGTGCCGCTGCTGGTGG
CGTAACTTACCTGAATAATGCCGGCACTTTTTCAACAGTTACGACTGGTAAGACGACACCGGTGAAGGTAAGTAACTCGA
ACGTGAAGGGCGAATCTGATGCAACGAAGGCCTTTAACAAGGTGTCGGGCGCAGTTGTGTCAGTGATTAACTTGCAAAAG
CAACAATCACTTTCAGACAGCGGCTCATTATTTGGTGGGTTGTTTGGTGGTGATGAGTCATCGTCAAGTGATAGCAAGTC
AACAGATTCATCAGACCTTCAAACGGCTTCTGAGGGATCAGGAGTGGTTTACAAGAAGGATGGTAACACGGCTTATATCG
TCACGAACAACCACGTGGTTTCAGGGTCAAACGCGTTGCAAGTCTTGTTGAGCGATGGGACTAAGCTGACGGCGACGTTG
GTTGGTACTGATGAGCAAACTGATTTGGCTGTGTTGAAGATTAATGCAAGCAAGGTATCAGAGGTAGCTGACTTTGCTAA
CTCAAGTAAGATTGAGCCGGGACAATCAGTTTTGGCCATCGGGTCACCATTGGGATCAGAGTATGCGACGTCAGTGACAG
AAGGAATCATTTCAGCAACGAAGCGTGAAGTCGATGCCACAAATGAGAATGGTGATTCACTCGGTAAGGCCACGGTTATC
CAAACGGACGCGGCAATTAATCCCGGAAATTCAGGTGGCCCATTGGTAAACTTGGCCGGTCAAGTCGTTGGTATCAACTC
AATGAAGTTGGCATCGTCAACTGACGGTACGTCGGTTGAAGGAATGGGATTTGCGATTCCGGCTAATACGGTAGTCAACA
TCATTAACGAGTTGGAGAAGAATGGAAAGGTTGAACGACCAGCTTTGGGCGTTTCAATGGTTGATTTGAGTAACGTCTCA
ACGACGGATCAATCAACAATCTTGAAGTTGCCAACCAGCGTTTCAGGTGGTGTCGTGGTCATCAGTACTGAAGATGGTTC
AGCAGCAGCGACTGCGGGCTTGAAGAAGTACGATGTGATTACCAAGATTGACGATACTGAGGTTACTGGTTCTGGTGACT
TGCGAGATGCTTTGTATAAGCACAAGGTTGGTGACACGATTAAGGTAACTTACTACCGCGATGGTAAGCAAAAGACGACT
GACGTGAAATTGACGAAGACGACGAGCTCATTATCAACGAAGTCAGAAGCAAATCAAAACTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(194-409)

PDZ domain (PDZ_2)

(307-404)

Trypsin-like peptidase domain (Trypsin_2)

(119-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1X4JLK3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

49.637

98.333

0.488
  htrA Streptococcus mutans UA159

50.646

92.143

0.467
  htrA Streptococcus mitis NCTC 12261

48.13

95.476

0.46
  htrA Streptococcus pneumoniae TIGR4

51.676

85.238

0.44
  htrA Streptococcus pneumoniae D39

51.676

85.238

0.44
  htrA Streptococcus pneumoniae Rx1

51.676

85.238

0.44
  htrA Streptococcus pneumoniae R6

51.676

85.238

0.44

Multiple sequence alignment