Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   AU077_RS07595 Genome accession   NZ_CP013688
Coordinates   1518766..1520682 (-) Length   638 a.a.
NCBI ID   WP_058621869.1    Uniprot ID   -
Organism   Streptococcus gallolyticus strain ICDDRB-NRC-S1     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1513766..1525682
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AU077_RS07570 (AU077_07570) - 1514435..1514791 (-) 357 WP_014294074.1 S1 RNA-binding domain-containing protein -
  AU077_RS07575 (AU077_07575) - 1514791..1516191 (-) 1401 WP_014294073.1 Cof-type HAD-IIB family hydrolase -
  AU077_RS07580 (AU077_07580) - 1516310..1516954 (-) 645 WP_009853571.1 response regulator transcription factor -
  AU077_RS07585 (AU077_07585) - 1516938..1517963 (-) 1026 WP_014294072.1 sensor histidine kinase -
  AU077_RS07590 (AU077_07590) liaF 1517960..1518655 (-) 696 WP_014294071.1 cell wall-active antibiotics response protein LiaF -
  AU077_RS07595 (AU077_07595) pknB 1518766..1520682 (-) 1917 WP_058621869.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  AU077_RS07600 (AU077_07600) - 1520682..1521419 (-) 738 WP_014294069.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  AU077_RS07605 (AU077_07605) rsmB 1521457..1522779 (-) 1323 WP_014294068.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  AU077_RS07610 (AU077_07610) fmt 1522769..1523704 (-) 936 WP_039670518.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 638 a.a.        Molecular weight: 69023.17 Da        Isoelectric Point: 4.9116

>NTDB_id=164061 AU077_RS07595 WP_058621869.1 1518766..1520682(-) (pknB) [Streptococcus gallolyticus strain ICDDRB-NRC-S1]
MIQIGKLFAGRYRILKSIGRGGMADVYLAKDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKDGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENKNVP
QALENVVIKATAKRLSDRYASTFEMSRDLMTALFYNRSREPKLVFEDTENTKTLPKVTTSTSVPSTTEQLLKKQKAAKED
KAATENKATKAKTKKKKSHRMFGTLMKIFFAVVIVAIAIFTYLTLTSPSTVSVPDVAGSSLSEAKTTIKSSGLKVGTVHE
VSSDTVESGYVIKTSPTAGSSKKEGSSIDIYVSKGLSGFKIKDYTGQDYQTAVKDLVNNYGVSESQIEIEEVSTSDYDEG
VIISQTPSEGGTFKVSGDDKITFKVATESTVTMPNLTGYTYSEAIAALTALGVSSSHITAYQANPNSSTGYVQVSSPSST
ATVTAQTPYYGDTLSDNVVLYLAADEEESSQAPSSSISESSESKESSSSSSESSESKESSSSSSSTDDSSSSTETSDE

Nucleotide


Download         Length: 1917 bp        

>NTDB_id=164061 AU077_RS07595 WP_058621869.1 1518766..1520682(-) (pknB) [Streptococcus gallolyticus strain ICDDRB-NRC-S1]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATCCTCAAATCTATCGGACGGGGTGGAATGGCAGATGTTTA
TCTGGCAAAAGATCTCATTCTTGATAATGAAGAAGTTGCCATTAAGGTGCTTCGGACGAATTATCAGACTGATCAAATTG
CCGTAGCGCGTTTCCAACGGGAAGCGCGTGCCATGGCAGAACTGAACCATCCAAATATTGTCTCGATTCGTGATATTGGA
GAAGAAGATGGACAGCAATTCTTAGTAATGGAATATGTTGATGGCTCGGACTTAAAAAAATACATTCAAGATCATGCTCC
GCTTTCTAATAATGAAGTTGTTAGAATCATGGAAGAAGTCCTATCTGCGATGACTTTGGCGCATCAACAAGGAATTGTTC
ACCGTGATTTAAAACCACAAAATATATTATTAACCAAAGACGGAACTGTTAAAGTTACTGATTTTGGTATCGCCGTAGCC
TTTGCCGAAACAAGTTTAACGCAAACCAATTCAATGCTAGGTAGTGTGCATTATTTATCGCCTGAACAAGCACGTGGTTC
AAAAGCGACTGTTCAAAGTGATATTTACGCTATGGGGATTATGTTGTTTGAAATGTTAACAGGTCACATCCCATATGATG
GCGATTCAGCTGTTACCATTGCGCTTCAACATTTCCAAAAACCACTTCCTTCCATCATTGATGAGAATAAAAATGTGCCA
CAAGCACTAGAAAATGTTGTTATCAAGGCGACTGCAAAACGTTTAAGTGACCGTTATGCGTCAACTTTTGAAATGAGTCG
TGATTTGATGACGGCACTTTTTTACAACCGTAGCCGTGAACCTAAACTTGTTTTTGAAGATACTGAAAATACAAAGACAC
TTCCAAAGGTAACAACATCAACATCTGTTCCTTCAACGACAGAACAACTTTTGAAGAAACAAAAAGCAGCTAAAGAAGAT
AAAGCAGCAACAGAAAACAAAGCGACTAAAGCTAAAACAAAGAAGAAAAAATCACATCGTATGTTCGGCACGTTAATGAA
AATCTTTTTTGCAGTTGTGATTGTAGCTATTGCTATCTTTACATACTTGACGTTGACCTCACCATCAACCGTGAGTGTTC
CAGATGTTGCTGGCTCTAGTTTATCAGAAGCAAAAACAACGATAAAATCATCAGGTCTTAAAGTTGGAACCGTTCATGAA
GTATCAAGCGATACCGTCGAGAGTGGTTACGTTATTAAGACAAGTCCAACTGCTGGTTCATCGAAAAAAGAAGGGTCATC
AATTGATATTTACGTATCAAAAGGCTTATCAGGATTCAAGATAAAAGACTATACAGGTCAAGATTATCAAACAGCCGTTA
AAGATTTGGTTAATAATTATGGTGTTTCAGAGTCGCAAATTGAGATTGAAGAAGTCTCAACGTCAGATTATGACGAAGGT
GTTATCATCAGTCAAACACCTAGCGAAGGTGGAACCTTTAAGGTAAGTGGTGATGATAAGATTACCTTTAAAGTAGCTAC
TGAGAGTACAGTAACAATGCCGAATTTGACAGGATATACTTATTCAGAAGCTATTGCTGCCCTGACGGCTCTAGGTGTAT
CAAGTTCACATATTACGGCTTATCAAGCCAATCCCAATTCATCTACGGGTTATGTGCAAGTAAGCTCACCATCTTCAACA
GCAACTGTCACTGCTCAGACACCATATTATGGTGATACACTAAGTGATAACGTGGTACTTTACCTAGCAGCTGATGAAGA
AGAAAGCTCACAGGCACCATCGTCATCAATCTCAGAATCCTCTGAATCAAAAGAATCAAGTTCATCAAGCTCAGAATCCT
CTGAATCAAAAGAATCAAGTTCATCAAGCAGTAGTACAGATGACAGTAGCTCATCGACAGAAACAAGTGATGAATAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-247)

PASTA domain (PASTA)

(511-580)

PASTA domain (PASTA)

(440-506)

PASTA domain (PASTA)

(371-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

68.484

92.006

0.63
  stkP/pknB Streptococcus salivarius strain HSISS4

64.856

92.32

0.599
  stkP Streptococcus pneumoniae D39

52.222

98.746

0.516
  stkP Streptococcus pneumoniae R6

52.222

98.746

0.516
  stkP Streptococcus pneumoniae TIGR4

58.161

83.542

0.486
  stkP Streptococcus pneumoniae Rx1

57.786

83.542

0.483

Multiple sequence alignment