Detailed information NTG0163761

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: AUQ45_RS00325
• Genome accession: NZ_CP013672
• Coordinates: 53396..54307 (+)
• Length: 303 a.a.
• NCBI ID: WP_014635220.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain AP53
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48396..59307

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AUQ45_RS00305 (AUQ45_0029)	purE	48691..49182 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
AUQ45_RS00310 (AUQ45_0030)	purK	49169..50242 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
AUQ45_RS00315 (AUQ45_0031)	-	50263..51603 (+)	1341	WP_014635219.1	hypothetical protein	-
AUQ45_RS00320 (AUQ45_0033)	purB	51973..53265 (+)	1293	WP_002986683.1	adenylosuccinate lyase	-
AUQ45_RS00325 (AUQ45_0034)	comR	53396..54307 (+)	912	WP_014635220.1	XRE family transcriptional regulator	Regulator
AUQ45_RS10075	comS	54398..54496 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
AUQ45_RS00330 (AUQ45_0035)	ruvB	54527..55525 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
AUQ45_RS00335 (AUQ45_0036)	-	55663..56100 (+)	438	WP_014635221.1	low molecular weight protein-tyrosine-phosphatase	-
AUQ45_RS00340 (AUQ45_0037)	-	56123..56524 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
AUQ45_RS00345 (AUQ45_0038)	-	56521..58296 (+)	1776	WP_014635222.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35925.63 Da
• Isoelectric Point: 4.9349

>NTDB_id=163761 AUQ45_RS00325 WP_014635220.1 53396..54307(+) (comR) [Streptococcus pyogenes strain AP53]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=163761 AUQ45_RS00325 WP_014635220.1 53396..54307(+) (comR) [Streptococcus pyogenes strain AP53]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.492	98.68	0.469
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366