Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   HSISS4_RS00850 Genome accession   NZ_CP013216
Coordinates   157733..158482 (+) Length   249 a.a.
NCBI ID   WP_021143484.1    Uniprot ID   A0A074IYL9
Organism   Streptococcus salivarius strain HSISS4     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 152733..163482
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HSISS4_RS00830 (HSISS4_00124) - 153748..154488 (-) 741 WP_002949253.1 amino acid ABC transporter ATP-binding protein -
  HSISS4_RS00835 (HSISS4_00125) - 154488..156035 (-) 1548 WP_021143482.1 ABC transporter substrate-binding protein/permease -
  HSISS4_RS00840 (HSISS4_00126) - 156241..157095 (+) 855 WP_002883622.1 undecaprenyl-diphosphate phosphatase -
  HSISS4_RS00845 (HSISS4_00127) - 157155..157526 (-) 372 WP_037620112.1 DUF3021 family protein -
  HSISS4_RS00850 (HSISS4_00128) mecA 157733..158482 (+) 750 WP_021143484.1 adaptor protein MecA Regulator
  HSISS4_RS00855 (HSISS4_00129) - 158486..159643 (+) 1158 WP_021143485.1 glycosyltransferase family 4 protein -
  HSISS4_RS00860 (HSISS4_00130) sufC 159805..160575 (+) 771 WP_002883600.1 Fe-S cluster assembly ATPase SufC -
  HSISS4_RS00865 (HSISS4_00131) sufD 160612..161874 (+) 1263 WP_021143486.1 Fe-S cluster assembly protein SufD -
  HSISS4_RS00870 (HSISS4_00132) - 161928..163160 (+) 1233 WP_021143487.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29086.66 Da        Isoelectric Point: 4.0182

>NTDB_id=160685 HSISS4_RS00850 WP_021143484.1 157733..158482(+) (mecA) [Streptococcus salivarius strain HSISS4]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMDDYSGLSPEEFLKALEGNFMDKGDIEAHHKLEELEKTLEEVDKAMTEPTKEVAEENIREDYTHYVLAF
SDFDQVVTFTQGLKDVPVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRAYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=160685 HSISS4_RS00850 WP_021143484.1 157733..158482(+) (mecA) [Streptococcus salivarius strain HSISS4]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAATT
GAAAGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTACACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGCGGGATGCTGAGCTTCCGTGTCACGCCACGCAAGGACCGTGTGGATGTCTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAACGATTTGTCGGATATGGACGACTACTCAGGGCTTTCTCCAGAAGAGTTCCTCAAGGCTCT
TGAGGGGAACTTTATGGACAAGGGGGATATCGAAGCACACCATAAGCTCGAAGAGCTTGAAAAGACCTTGGAAGAGGTTG
ATAAGGCTATGACAGAGCCTACAAAGGAAGTGGCTGAAGAAAATATTCGTGAAGACTATACCCACTATGTCTTGGCTTTC
TCTGACTTTGATCAAGTGGTGACCTTTACGCAAGGCTTGAAGGATGTGCCAGTTGAAGGTTCTGAGCTTTATAAACTTGG
GGATGTCTACTATATGACAATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTGCCTACCTGCAAGAGCATGCAACAATTTTGATGGAAGAGGACGCCTTG
CCGGTACTACAAGCAACGAAATGGAGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A074IYL9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

94.378

100

0.944
  mecA Streptococcus thermophilus LMG 18311

93.574

100

0.936
  mecA Streptococcus mutans UA159

60.246

97.992

0.59
  mecA Streptococcus pneumoniae Rx1

47.39

100

0.474
  mecA Streptococcus pneumoniae D39

47.39

100

0.474
  mecA Streptococcus pneumoniae R6

47.39

100

0.474
  mecA Streptococcus pneumoniae TIGR4

47.39

100

0.474

Multiple sequence alignment