Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Machinery gene
Locus tag   ACT74_RS10120 Genome accession   NZ_CP012958
Coordinates   2093052..2093756 (-) Length   234 a.a.
NCBI ID   WP_014167482.1    Uniprot ID   -
Organism   Aggregatibacter actinomycetemcomitans strain VT1169     
Function   require for natural transformation (predicted from homology)   
Unclear

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2050406..2116485 2093052..2093756 within 0


Gene organization within MGE regions


Location: 2050406..2116485
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACT74_RS09930 (ACT74_09925) rluA 2050424..2051083 (-) 660 WP_005567062.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
  ACT74_RS09935 (ACT74_09930) pnuC 2051464..2052153 (+) 690 WP_005548127.1 nicotinamide riboside transporter PnuC -
  ACT74_RS09940 (ACT74_09935) - 2052228..2052935 (-) 708 WP_005572000.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  ACT74_RS09945 (ACT74_09940) srmB 2053025..2054356 (+) 1332 WP_005572001.1 ATP-dependent RNA helicase SrmB -
  ACT74_RS09950 (ACT74_09945) - 2054827..2056128 (+) 1302 WP_005548134.1 ATP-binding protein -
  ACT74_RS09955 (ACT74_09950) - 2056187..2057587 (+) 1401 WP_014167492.1 SIR2 family protein -
  ACT74_RS09960 (ACT74_09955) - 2057590..2058072 (+) 483 WP_081107557.1 TIR domain-containing protein -
  ACT74_RS09965 (ACT74_09960) - 2058100..2058744 (+) 645 WP_014167491.1 TIR domain-containing protein -
  ACT74_RS09970 (ACT74_09965) pdxH 2058832..2059464 (-) 633 WP_005548142.1 pyridoxamine 5'-phosphate oxidase -
  ACT74_RS09975 (ACT74_09970) uhpC 2059635..2060960 (+) 1326 WP_005541809.1 MFS transporter family glucose-6-phosphate receptor UhpC -
  ACT74_RS09980 (ACT74_09975) - 2061078..2061371 (-) 294 WP_005541810.1 hypothetical protein -
  ACT74_RS09985 (ACT74_09980) pgaC 2061374..2062609 (-) 1236 WP_005548147.1 poly-beta-1,6-N-acetyl-D-glucosamine synthase -
  ACT74_RS09990 (ACT74_09985) pgaB 2062618..2064534 (-) 1917 WP_005548149.1 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB -
  ACT74_RS09995 (ACT74_09990) pgaA 2064550..2066937 (-) 2388 WP_005567053.1 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA -
  ACT74_RS10000 (ACT74_09995) deoD 2067240..2067959 (-) 720 WP_005548156.1 purine-nucleoside phosphorylase -
  ACT74_RS10005 (ACT74_10000) - 2068085..2069335 (-) 1251 WP_014167488.1 NupC/NupG family nucleoside CNT transporter -
  ACT74_RS10010 (ACT74_10005) - 2069627..2070802 (-) 1176 WP_014167487.1 Cof-type HAD-IIB family hydrolase -
  ACT74_RS10015 (ACT74_10010) manZ 2070912..2071748 (-) 837 WP_005548161.1 PTS mannose transporter subunit IID -
  ACT74_RS10020 (ACT74_10015) - 2071762..2072559 (-) 798 WP_005567049.1 PTS mannose/fructose/sorbose transporter subunit IIC -
  ACT74_RS10845 - 2072577..2073542 (-) 966 WP_005548165.1 mannose/fructose/sorbose PTS transporter subunit IIB -
  ACT74_RS10030 (ACT74_10025) rsmD 2073829..2074413 (-) 585 WP_005548167.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  ACT74_RS10035 (ACT74_10030) ftsY 2074501..2075862 (+) 1362 WP_014167486.1 signal recognition particle-docking protein FtsY -
  ACT74_RS10040 (ACT74_10035) trpS 2076037..2077041 (+) 1005 WP_005567048.1 tryptophan--tRNA ligase -
  ACT74_RS10045 (ACT74_10040) ribB 2077128..2077772 (-) 645 WP_005548174.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
  ACT74_RS10050 (ACT74_10045) - 2078452..2079225 (-) 774 WP_005548176.1 M48 family metallopeptidase -
  ACT74_RS10055 (ACT74_10050) ppa 2079301..2079828 (-) 528 WP_005548178.1 inorganic diphosphatase -
  ACT74_RS10060 (ACT74_10055) mtr 2079990..2081234 (+) 1245 WP_005567043.1 tryptophan permease -
  ACT74_RS10065 (ACT74_10060) - 2081513..2081830 (+) 318 WP_005567042.1 DUF4298 domain-containing protein -
  ACT74_RS10070 (ACT74_10065) aphA 2082212..2082919 (-) 708 WP_005567041.1 acid phosphatase AphA -
  ACT74_RS10075 (ACT74_10070) hslV 2083134..2083661 (+) 528 WP_005554522.1 ATP-dependent protease subunit HslV -
  ACT74_RS10080 (ACT74_10075) hslU 2083682..2085013 (+) 1332 WP_005589872.1 HslU--HslV peptidase ATPase subunit -
  ACT74_RS10085 (ACT74_10080) nikA 2085079..2086662 (+) 1584 WP_061870024.1 nickel ABC transporter substrate-binding protein -
  ACT74_RS10090 (ACT74_10085) - 2086761..2087504 (+) 744 WP_032996149.1 VacJ family lipoprotein -
  ACT74_RS10095 (ACT74_10090) - 2087522..2088016 (+) 495 WP_005548195.1 YfbU family protein -
  ACT74_RS10100 (ACT74_10095) - 2088101..2088784 (-) 684 WP_005567036.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
  ACT74_RS10105 (ACT74_10100) - 2089090..2090748 (+) 1659 WP_061870025.1 phospho-sugar mutase -
  ACT74_RS10110 (ACT74_10105) envC 2090957..2092216 (+) 1260 WP_005571010.1 murein hydrolase activator EnvC -
  ACT74_RS10115 (ACT74_10110) - 2092222..2093040 (+) 819 WP_390883557.1 divergent polysaccharide deacetylase family protein -
  ACT74_RS10120 (ACT74_10115) comM 2093052..2093756 (-) 705 WP_014167482.1 ATP-binding protein Machinery gene
  ACT74_RS10125 (ACT74_10120) - 2093892..2094554 (+) 663 WP_005559213.1 heteromeric transposase endonuclease subunit TnsA -
  ACT74_RS10130 (ACT74_10125) - 2094547..2096466 (+) 1920 WP_005559215.1 Mu transposase C-terminal domain-containing protein -
  ACT74_RS10135 (ACT74_10130) - 2096466..2097935 (+) 1470 WP_061870026.1 TniB family NTP-binding protein -
  ACT74_RS10140 (ACT74_10135) - 2097896..2099347 (+) 1452 WP_005567030.1 hypothetical protein -
  ACT74_RS10145 (ACT74_10140) - 2099471..2099689 (+) 219 WP_019518360.1 hypothetical protein -
  ACT74_RS10150 (ACT74_10145) - 2099825..2100133 (-) 309 WP_005591951.1 transcriptional regulator -
  ACT74_RS10155 (ACT74_10150) - 2100175..2101269 (+) 1095 WP_231098013.1 recombinase family protein -
  ACT74_RS10160 (ACT74_10155) - 2101271..2101894 (+) 624 WP_005567028.1 ParB/RepB/Spo0J family partition protein -
  ACT74_RS10165 (ACT74_10160) - 2101887..2102741 (+) 855 WP_005559223.1 ParB/RepB/Spo0J family partition protein -
  ACT74_RS10170 (ACT74_10165) - 2102860..2103144 (-) 285 WP_019518356.1 hypothetical protein -
  ACT74_RS10180 (ACT74_10175) - 2103563..2104078 (-) 516 WP_061870027.1 Imm15 family immunity protein -
  ACT74_RS10185 (ACT74_10180) tssI 2104082..2109530 (-) 5449 Protein_2011 type VI secretion system tip protein TssI/VgrG -
  ACT74_RS10190 (ACT74_10185) - 2109802..2110461 (+) 660 WP_005559230.1 DNA adenine methylase -
  ACT74_RS10195 (ACT74_10190) - 2110477..2111304 (+) 828 WP_005559233.1 Thermostable 8-oxoguanine DNA glycosylase -
  ACT74_RS10855 - 2111242..2111925 (-) 684 WP_005593449.1 hypothetical protein -
  ACT74_RS10200 (ACT74_10195) - 2111909..2112505 (-) 597 WP_005559235.1 7-cyano-7-deazaguanine synthase -
  ACT74_RS10205 (ACT74_10200) - 2112541..2113788 (-) 1248 WP_005567021.1 PfkB family carbohydrate kinase -
  ACT74_RS10210 (ACT74_10205) - 2113798..2114148 (-) 351 WP_005585358.1 hypothetical protein -
  ACT74_RS10215 (ACT74_10210) - 2114376..2116124 (-) 1749 WP_061870028.1 hypothetical protein -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26130.98 Da        Isoelectric Point: 9.4430

>NTDB_id=158594 ACT74_RS10120 WP_014167482.1 2093052..2093756(-) (comM) [Aggregatibacter actinomycetemcomitans strain VT1169]
MPLICNFDSGTIPKPGEISLAHNGVLFLDELPEFERKVLDALRQPLESGEIIISRANAKIQFPAKFQLIAAMNPSPTGHY
QGTHNRTSPQQVMRYLNRLSGPFLDRFDLSIEVPLLPQGSLQNSGDRGESSATVREKVLKTRAIQLQRAGKINAHLNSKE
IERDCKLTDKDAQFLENALTKLGLSVRAYHRILKVSRTIADLDGEQHINQCHLAEALGYRAMDRLLQKLAKNSA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=158594 ACT74_RS10120 WP_014167482.1 2093052..2093756(-) (comM) [Aggregatibacter actinomycetemcomitans strain VT1169]
ATGCCACTTATTTGTAACTTTGACAGCGGCACGATCCCCAAACCGGGCGAAATTTCCCTCGCTCACAATGGCGTGCTTTT
CTTAGATGAGTTGCCCGAATTTGAACGCAAAGTGCTGGACGCGCTGCGTCAACCATTGGAAAGTGGCGAAATTATTATTT
CCCGCGCCAACGCCAAGATTCAATTTCCGGCAAAATTTCAACTGATTGCCGCGATGAATCCCAGCCCGACAGGGCATTAT
CAAGGCACGCATAATCGCACCTCACCACAACAAGTTATGCGTTATCTGAATCGGTTATCCGGCCCTTTTTTAGATCGCTT
CGATTTATCCATTGAAGTGCCCTTATTACCACAAGGCAGCTTACAAAATAGCGGCGATCGTGGCGAATCCAGCGCAACGG
TGCGAGAAAAAGTCCTGAAAACCCGTGCCATTCAACTTCAGCGCGCCGGCAAAATTAATGCCCATTTAAATAGCAAAGAA
ATCGAACGGGACTGCAAACTAACCGACAAAGACGCACAGTTCCTGGAAAATGCCCTGACTAAACTGGGGCTTTCCGTACG
AGCGTACCACCGCATACTGAAAGTGTCCCGCACCATTGCCGATTTAGATGGAGAACAACACATCAACCAGTGCCATCTGG
CCGAAGCTCTGGGTTATCGGGCAATGGACAGGTTGTTGCAAAAATTGGCGAAAAACTCGGCGTAA

Domains

Predicted by InterproScan.

Magnesium chelatase, subunit ChlI C-terminal (Mg_chelatase_C)

(128-220)

Magnesium chelatase, subunit ChlI (Mg_chelatase)

(9-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Haemophilus influenzae Rd KW20

86.957

98.291

0.855
  comM Glaesserella parasuis strain SC1401

81.034

99.145

0.803
  comM Vibrio cholerae strain A1552

67.873

94.444

0.641
  comM Vibrio campbellii strain DS40M4

65.909

94.017

0.62
  RA0C_RS07335 Riemerella anatipestifer ATCC 11845 = DSM 15868

52

96.154

0.5
  comM Legionella pneumophila str. Paris

51.869

91.453

0.474
  comM Legionella pneumophila strain ERS1305867

51.869

91.453

0.474

Multiple sequence alignment