Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   UB18_RS12145 Genome accession   NZ_CP011828
Coordinates   2505173..2506459 (+) Length   428 a.a.
NCBI ID   WP_061573537.1    Uniprot ID   -
Organism   Enterococcus faecium strain UW8175     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2500173..2511459
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UB18_RS14915 - 2500454..2500846 (-) 393 WP_002287845.1 hypothetical protein -
  UB18_RS12125 (UB18_12130) - 2501274..2501966 (-) 693 WP_002338602.1 hypothetical protein -
  UB18_RS12130 (UB18_12135) - 2502271..2503440 (-) 1170 WP_002347330.1 IS256 family transposase -
  UB18_RS12135 (UB18_12140) - 2503511..2504062 (-) 552 WP_002299296.1 PD-(D/E)XK nuclease family protein -
  UB18_RS12140 (UB18_12145) rlmH 2504265..2504744 (-) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  UB18_RS12145 (UB18_12150) htrA 2505173..2506459 (+) 1287 WP_061573537.1 S1C family serine protease Regulator
  UB18_RS12150 (UB18_12155) ytpR 2506624..2507229 (-) 606 WP_002349782.1 YtpR family tRNA-binding protein -
  UB18_RS12155 (UB18_12160) - 2507434..2507898 (-) 465 WP_002287838.1 universal stress protein -
  UB18_RS12160 (UB18_12165) - 2507920..2508240 (-) 321 WP_002287837.1 thioredoxin family protein -
  UB18_RS12165 (UB18_12170) pepA 2508383..2509462 (-) 1080 WP_002351291.1 glutamyl aminopeptidase -
  UB18_RS12170 (UB18_12175) - 2509662..2510012 (+) 351 WP_002289862.1 PepSY domain-containing protein -
  UB18_RS12175 (UB18_12180) - 2510235..2511182 (+) 948 WP_061573538.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44841.84 Da        Isoelectric Point: 4.5419

>NTDB_id=148891 UB18_RS12145 WP_061573537.1 2505173..2506459(+) (htrA) [Enterococcus faecium strain UW8175]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGTEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=148891 UB18_RS12145 WP_061573537.1 2505173..2506459(+) (htrA) [Enterococcus faecium strain UW8175]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTAGGGCTTGT
TGGAGGGATCGTTGGAGGATTACTGACAGCTGGTATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCAGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTGCAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAAAAG
ACGGGAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGTCGA
AACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCATTAGGAACTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Peptidase family M50 (Peptidase_M50)

(11-416)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.453

91.822

0.5
  htrA Streptococcus mutans UA159

59.605

82.71

0.493
  htrA Streptococcus mitis NCTC 12261

52.393

92.757

0.486
  htrA Streptococcus pneumoniae TIGR4

58.754

78.738

0.463
  htrA Streptococcus pneumoniae Rx1

58.754

78.738

0.463
  htrA Streptococcus pneumoniae D39

58.754

78.738

0.463
  htrA Streptococcus pneumoniae R6

58.754

78.738

0.463

Multiple sequence alignment