Detailed information NTG0137361

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SD90_RS00330
• Genome accession: NZ_CP010450
• Coordinates: 53108..54019 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NGAS638
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48108..59019

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SD90_RS00310 (SD90_00310)	purE	48694..49185 (+)	492	WP_032463145.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SD90_RS00315 (SD90_00315)	purK	49172..50245 (+)	1074	WP_032463119.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SD90_RS09420	-	50247..50987 (+)	741	WP_229764247.1	hypothetical protein	-
SD90_RS09425	-	50996..51664 (+)	669	WP_229764248.1	hypothetical protein	-
SD90_RS00325 (SD90_00325)	purB	51684..52976 (+)	1293	WP_030127622.1	adenylosuccinate lyase	-
SD90_RS00330 (SD90_00330)	comR	53108..54019 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
SD90_RS09645	comS	54103..54198 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
SD90_RS00335 (SD90_00335)	ruvB	54245..55243 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
SD90_RS00340 (SD90_00340)	-	55381..55818 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
SD90_RS00345 (SD90_00345)	-	55841..56242 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
SD90_RS00350 (SD90_00350)	-	56239..58014 (+)	1776	WP_002986669.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=137361 SD90_RS00330 WP_002986681.1 53108..54019(+) (comR) [Streptococcus pyogenes strain NGAS638]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=137361 SD90_RS00330 WP_002986681.1 53108..54019(+) (comR) [Streptococcus pyogenes strain NGAS638]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462