Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SAHN016_RS05075 Genome accession   NZ_CP011325
Coordinates   1007407..1008087 (-) Length   226 a.a.
NCBI ID   WP_000590620.1    Uniprot ID   Q8DZW1
Organism   Streptococcus agalactiae strain HN016     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1002407..1013087
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SAHN016_RS05050 (SAHN016_05055) - 1002590..1003363 (-) 774 WP_000622398.1 DUF3307 domain-containing protein -
  SAHN016_RS05055 (SAHN016_05060) - 1003353..1004039 (-) 687 WP_000280308.1 SatD family protein -
  SAHN016_RS05060 (SAHN016_05065) ffh 1004106..1005671 (-) 1566 WP_000863589.1 signal recognition particle protein -
  SAHN016_RS05065 (SAHN016_05070) - 1005689..1006021 (-) 333 WP_000402075.1 putative DNA-binding protein -
  SAHN016_RS05070 (SAHN016_05075) ciaH 1006110..1007423 (-) 1314 WP_000042576.1 sensor histidine kinase Regulator
  SAHN016_RS05075 (SAHN016_05080) ciaR 1007407..1008087 (-) 681 WP_000590620.1 response regulator transcription factor Regulator
  SAHN016_RS05080 (SAHN016_05085) - 1008249..1010798 (-) 2550 WP_000859382.1 M1 family metallopeptidase -
  SAHN016_RS05085 (SAHN016_05090) phoU 1010944..1011597 (-) 654 WP_000946330.1 phosphate signaling complex protein PhoU -
  SAHN016_RS05090 (SAHN016_05095) pstB 1011631..1012389 (-) 759 WP_000193363.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25852.63 Da        Isoelectric Point: 4.2507

>NTDB_id=127367 SAHN016_RS05075 WP_000590620.1 1007407..1008087(-) (ciaR) [Streptococcus agalactiae strain HN016]
MIKILLIEDDLSLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD

Nucleotide


Download         Length: 681 bp        

>NTDB_id=127367 SAHN016_RS05075 WP_000590620.1 1007407..1008087(-) (ciaR) [Streptococcus agalactiae strain HN016]
ATGATAAAAATTTTATTAATTGAAGATGACTTGAGTCTTTCCAATTCCGTTTTTGATTTCCTTGATGACTTTGCCGATGT
CATGCAAATTTTTGATGGAGAAGAGGGTCTTTACGAAGCCGAAAGTGGAGTCTATGATCTGATTCTTCTAGATCTCATGT
TACCTGAAAAAAACGGCTTCCAAGTGTTGAAAGAGCTACGTGAAAAAGGTATTACAACCCCTGTATTAATAATGACCGCT
AAAGAAAGCATTGATGATAAGGGACAAGGTTTCGACTTAGGTGCTGATGATTATCTAACAAAACCTTTTTACCTAGAAGA
ACTAAAAATGCGAATTCAGGCTCTTTTAAAGCGTTCTGGAAAATTTAATGATAACAGCCTAATTTATGGTGATATTCGCG
TAGACATGTCTACTAACTCAACCTTTGTTAATCAAACAGAAGTTGAGCTCTTAGGTAAAGAGTTTGATCTTTTAGTCTAT
TTCCTTCAAAATCAAAATGTTATCTTACCGAAATCTCAAATCTTTGATCGTATTTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTCTATGTCTCTAAGGTTCGGAAAAAATTAAAAGGAACACTTTTTTCAGAAAACCTTCAAACTTTGC
GTAGTGTAGGATATATTTTAAAGCATGTCGAAACCGATTAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DZW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae D39

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae R6

88.393

99.115

0.876
  ciaR Streptococcus pneumoniae Rx1

88.393

99.115

0.876
  ciaR Streptococcus mutans UA159

88.688

97.788

0.867
  vicR Streptococcus mutans UA159

35.193

100

0.363
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.607

99.115

0.363

Multiple sequence alignment