Detailed information NTG0126326

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: DP17_RS02545
• Genome accession: NZ_CP009046
• Coordinates: 538102..539148 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain SEI
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 533102..544148

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DP17_RS02515 (DP17_508)	-	533486..534727 (-)	1242	WP_001832467.1	aminopeptidase	-
DP17_RS02520 (DP17_509)	-	534729..534944 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
DP17_RS02525 (DP17_510)	-	535085..535549 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
DP17_RS02530 (DP17_511)	-	535557..535841 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
DP17_RS02535 (DP17_512)	-	536248..537426 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
DP17_RS02540 (DP17_513)	vraR	537483..538112 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
DP17_RS02545 (DP17_514)	vraS	538102..539148 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
DP17_RS02550 (DP17_515)	liaF	539145..539846 (-)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
DP17_RS02555 (DP17_516)	-	539861..540247 (-)	387	WP_001830382.1	hypothetical protein	-
DP17_RS02560 (DP17_517)	map	540405..541160 (-)	756	WP_002457092.1	type I methionyl aminopeptidase	-
DP17_RS02565 (DP17_518)	-	541334..542320 (+)	987	WP_002457091.1	FUSC family protein	-
DP17_RS02570 (DP17_519)	isaB	542471..543007 (-)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=126326 DP17_RS02545 WP_001830374.1 538102..539148(-) (vraS) [Staphylococcus epidermidis strain SEI]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=126326 DP17_RS02545 WP_001830374.1 538102..539148(-) (vraS) [Staphylococcus epidermidis strain SEI]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92