Detailed information NTG0123612

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: FE90_RS09210
• Genome accession: NZ_CP008695
• Coordinates: 1844388..1845611 (+)
• Length: 407 a.a.
• NCBI ID: WP_002981947.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain M23ND
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1839388..1850611

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FE90_RS09190 (FE90_1861)	clpC	1839821..1842265 (+)	2445	WP_002991294.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
FE90_RS09195 (FE90_1862)	-	1842262..1843281 (-)	1020	WP_038433776.1	IS30-like element IS1239 family transposase	-
FE90_RS09205 (FE90_1863)	rlmH	1843697..1844176 (-)	480	WP_011889262.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FE90_RS09210 (FE90_1864)	htrA	1844388..1845611 (+)	1224	WP_002981947.1	S1C family serine protease	Regulator
FE90_RS09215 (FE90_1865)	spo0J	1845700..1846476 (+)	777	WP_002981939.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42758.40 Da
• Isoelectric Point: 7.3920

>NTDB_id=123612 FE90_RS09210 WP_002981947.1 1844388..1845611(+) (htrA) [Streptococcus pyogenes strain M23ND]
MPSMKHILKSLSVLLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKIVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=123612 FE90_RS09210 WP_002981947.1 1844388..1845611(+) (htrA) [Streptococcus pyogenes strain M23ND]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTGTTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTTAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGATTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAATAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (301-396)

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.634	99.263	0.612
htrA	Streptococcus gordonii str. Challis substr. CH1	55.473	98.771	0.548
htrA	Streptococcus mitis NCTC 12261	53.317	100	0.533
htrA	Streptococcus pneumoniae Rx1	53.071	100	0.531
htrA	Streptococcus pneumoniae D39	53.071	100	0.531
htrA	Streptococcus pneumoniae R6	53.071	100	0.531
htrA	Streptococcus pneumoniae TIGR4	53.071	100	0.531