Detailed information NTG0123561

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: FE90_RS00260
• Genome accession: NZ_CP008695
• Coordinates: 46970..47881 (+)
• Length: 303 a.a.
• NCBI ID: WP_038433069.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain M23ND
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 41970..52881

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FE90_RS00240 (FE90_0028)	purE	42559..43047 (+)	489	WP_038433064.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
FE90_RS00245 (FE90_0029)	purK	43034..44107 (+)	1074	WP_038433065.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
FE90_RS00250 (FE90_0030)	-	44109..45527 (+)	1419	WP_038433067.1	hypothetical protein	-
FE90_RS00255 (FE90_0031)	purB	45547..46839 (+)	1293	WP_011888525.1	adenylosuccinate lyase	-
FE90_RS00260 (FE90_0032)	comR	46970..47881 (+)	912	WP_038433069.1	helix-turn-helix domain-containing protein	Regulator
FE90_RS10070	comS	47972..48070 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
FE90_RS00265 (FE90_0033)	ruvB	48101..49099 (+)	999	WP_038433071.1	Holliday junction branch migration DNA helicase RuvB	-
FE90_RS00270 (FE90_0034)	-	49237..49674 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
FE90_RS00275	-	49697..50098 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
FE90_RS00280 (FE90_0036)	-	50095..51870 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35885.61 Da
• Isoelectric Point: 5.0238

>NTDB_id=123561 FE90_RS00260 WP_038433069.1 46970..47881(+) (comR) [Streptococcus pyogenes strain M23ND]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFVQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=123561 FE90_RS00260 WP_038433069.1 46970..47881(+) (comR) [Streptococcus pyogenes strain M23ND]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGTACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366