Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DK92_RS02595 Genome accession   NZ_CP007561
Coordinates   510415..512322 (+) Length   635 a.a.
NCBI ID   WP_047235721.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS596     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 505415..517322
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK92_RS02580 (DK92_02660) fmt 507393..508328 (+) 936 WP_002988958.1 methionyl-tRNA formyltransferase -
  DK92_RS02585 (DK92_02665) rsmB 508318..509640 (+) 1323 WP_047235720.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DK92_RS02590 (DK92_02670) - 509678..510418 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DK92_RS02595 (DK92_02675) pknB 510415..512322 (+) 1908 WP_047235721.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DK92_RS02600 (DK92_02680) liaF 512445..513137 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  DK92_RS02605 (DK92_02685) - 513134..514138 (+) 1005 WP_002991890.1 sensor histidine kinase -
  DK92_RS02610 (DK92_02690) - 514131..514772 (+) 642 WP_047235722.1 response regulator transcription factor -
  DK92_RS02615 (DK92_02695) - 514809..516209 (+) 1401 WP_023079249.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DK92_RS02620 (DK92_02700) - 516209..516586 (+) 378 WP_009880466.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 635 a.a.        Molecular weight: 69179.45 Da        Isoelectric Point: 7.0436

>NTDB_id=120887 DK92_RS02595 WP_047235721.1 510415..512322(+) (pknB) [Streptococcus pyogenes strain NGAS596]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKRYIQNHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKEGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQMPLPSIIEENHNVP
QALENVVIRATAKKLSDRYGSTFEMSRDLMTALSYNRSRERKIIFEDVESTKPLPKVASGPTASVKLSPPTPTVLTQESR
LDQTNQTNQTDALQPPTKKKKSGRFLGTLFKILFSFFIVGVALFTYLILTKPTSVKVPNVAGTSLKVAKQELYDVGLKVG
KIRQIESDTVAEGNVVRTDPKAGTAKRQGSSITLYVSIGNKGFDMENYKGLDYQEAMNSLIETYGVPKSKIKIERIVTNE
YPENTVISQSPSAGDKFNPNGKSKITLSVAVSDTITMPMVTEYSYADAVNTLTALGIDASRIKAYVPSSSSATGFVPIHS
PSSKAIVSGQSPYYGTSLSLSDKGEISLYLYPEETHSSSSSSSSTSSSNSSSTNDSTAPGSNTELSPSETTAQTP

Nucleotide


Download         Length: 1908 bp        

>NTDB_id=120887 DK92_RS02595 WP_047235721.1 510415..512322(+) (pknB) [Streptococcus pyogenes strain NGAS596]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGCATTCTGAAATCTATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGATTTGATCTTGGATAATGAAGACGTTGCAATCAAGGTCTTGCGTACCAATTATCAAACAGATCAGGTAG
CAGTTGCGCGTTTCCAACGGGAAGCGCGGGCCATGGCTGAATTGAACCATCCCAATATTGTTGCCATCCGGGATATAGGT
GAAGAAGACGGACAGCAATTTTTAGTAATGGAATATGTGGATGGTGCTGACCTAAAGAGATACATTCAAAATCATGCTCC
ATTATCTAATAATGAAGTGGTTAGAATTATGGAAGAAGTCCTTTCTGCTATGACTTTAGCCCACCAAAAAGGAATTGTAC
ACAGAGATTTAAAACCTCAAAATATCCTACTAACTAAGGAGGGGGTTGTCAAAGTAACTGATTTCGGCATCGCAGTAGCC
TTTGCAGAAACAAGCTTGACACAAACTAATTCGATGTTAGGCAGTGTTCATTACTTGTCTCCAGAACAGGCTCGCGGCTC
CAAAGCGACGATTCAAAGTGATATTTATGCGATGGGGATTATGCTCTTTGAGATGTTGACAGGCCATATCCCTTATGATG
GCGATAGTGCTGTTACGATTGCCTTGCAACATTTTCAAATGCCTCTTCCATCTATTATCGAGGAGAACCACAATGTGCCA
CAAGCTTTGGAGAATGTTGTTATTCGAGCAACAGCCAAGAAATTAAGTGATCGTTACGGGTCAACCTTTGAAATGAGTCG
TGACTTAATGACGGCGCTTAGTTATAATCGTAGTCGGGAGCGTAAGATTATCTTTGAGGATGTTGAAAGTACCAAACCCC
TCCCCAAAGTGGCCTCAGGTCCCACCGCTTCTGTAAAATTGTCTCCCCCTACCCCAACAGTGTTAACACAGGAAAGTCGA
TTAGATCAAACTAATCAAACTAATCAAACAGATGCTTTACAGCCCCCCACCAAAAAGAAAAAAAGTGGTCGTTTTTTAGG
TACTTTATTCAAAATTCTTTTTTCTTTCTTTATTGTAGGTGTAGCACTCTTTACTTATCTTATACTAACTAAACCAACTT
CTGTGAAAGTTCCTAATGTAGCAGGCACTAGTCTTAAAGTTGCCAAACAAGAACTGTATGATGTTGGGCTAAAAGTGGGT
AAAATCAGGCAAATTGAGAGTGATACGGTTGCTGAGGGAAATGTAGTTAGAACAGATCCTAAAGCAGGAACAGCTAAGAG
GCAAGGCTCAAGCATTACGCTTTATGTGTCAATTGGAAACAAAGGTTTTGACATGGAAAACTACAAAGGACTAGATTATC
AAGAAGCTATGAATAGTTTGATAGAAACTTATGGTGTTCCAAAATCAAAAATCAAAATTGAGCGCATTGTAACTAATGAA
TATCCTGAAAATACAGTCATCAGTCAATCGCCAAGTGCGGGTGATAAATTTAATCCAAACGGAAAGTCTAAAATTACGCT
CAGTGTTGCTGTTAGTGATACGATCACTATGCCTATGGTAACAGAATATAGTTATGCAGATGCAGTCAATACCTTAACAG
CTTTAGGTATAGATGCATCTAGAATAAAAGCTTATGTGCCAAGCTCTAGCTCAGCAACGGGCTTTGTGCCAATTCATTCT
CCTAGTTCTAAAGCTATTGTCAGTGGTCAATCTCCTTACTATGGAACGTCTTTGAGTCTGTCTGATAAAGGAGAGATCAG
TCTTTACCTTTATCCAGAAGAAACACACTCTTCTAGTAGCTCATCGAGTTCAACGTCAAGTTCAAACAGTTCTTCAACAA
ATGATAGTACTGCACCAGGTAGCAACACTGAATTAAGCCCATCAGAAACTACTGCTCAAACACCTTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(515-591)

PASTA domain (PASTA)

(444-509)

PASTA domain (PASTA)

(375-437)

Protein kinase domain (Pkinase)

(12-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

64.538

93.701

0.605
  stkP/pknB Streptococcus salivarius strain HSISS4

60.87

94.173

0.573
  stkP Streptococcus pneumoniae D39

57.617

80.63

0.465
  stkP Streptococcus pneumoniae R6

57.617

80.63

0.465
  stkP Streptococcus pneumoniae TIGR4

57.617

80.63

0.465
  stkP Streptococcus pneumoniae Rx1

57.422

80.63

0.463

Multiple sequence alignment