Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   DYB47_RS02265 Genome accession   NZ_UHFV01000002
Coordinates   409806..411653 (+) Length   615 a.a.
NCBI ID   WP_003078779.1    Uniprot ID   G5JY28
Organism   Streptococcus macacae NCTC 11558     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 404806..416653
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DYB47_RS02250 (NCTC11558_00457) fmt 406786..407721 (+) 936 WP_003081332.1 methionyl-tRNA formyltransferase -
  DYB47_RS02255 (NCTC11558_00458) rsmB 407675..409027 (+) 1353 WP_050897456.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  DYB47_RS02260 (NCTC11558_00459) - 409066..409806 (+) 741 WP_040841416.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  DYB47_RS02265 (NCTC11558_00460) pknB 409806..411653 (+) 1848 WP_003078779.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  DYB47_RS02270 (NCTC11558_00461) liaF 411833..412528 (+) 696 WP_003080079.1 cell wall-active antibiotics response protein LiaF -
  DYB47_RS02275 (NCTC11558_00462) - 412525..413535 (+) 1011 WP_003080812.1 sensor histidine kinase -
  DYB47_RS02280 (NCTC11558_00463) - 413522..414163 (+) 642 WP_003082065.1 response regulator transcription factor -
  DYB47_RS02285 (NCTC11558_00464) - 414202..415614 (+) 1413 WP_003080313.1 Cof-type HAD-IIB family hydrolase -
  DYB47_RS02290 (NCTC11558_00465) - 415601..415957 (+) 357 WP_003079785.1 S1 RNA-binding domain-containing protein -
  DYB47_RS09860 - 415962..416096 (+) 135 WP_003081823.1 hypothetical protein -

Sequence

Protein


Download         Length: 615 a.a.        Molecular weight: 67103.15 Da        Isoelectric Point: 9.2936

>NTDB_id=1171304 DYB47_RS02265 WP_003078779.1 409806..411653(+) (pknB) [Streptococcus macacae NCTC 11558]
MIQIGKLFAGRYRILQSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMSELNHPNIVAIRDIG
EEDGQQFLAMEYVDGADLKKYIQDHAPLSNAEVIRIMKEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIISENKNVP
QALENVVIKATAKRLTDRYTSTEEMLQDLKTCLQPNRSRERKLIFNDPSDTKPLPKLEQSMTSSTSAQALKDKAASKAAS
KEPKAKPKKKRGLLSRLLKLFFILVVLGIAVLAYMILTKPSTISVPNVSGYKLSSAKSKIVQAGLKVGQVRRIEDDSVDA
GKVVRTNPSAGSKKREGSSVDIFVSGTNSFVMENYIGQNYQSAIDNLTNTHGVPRDNIRIKEVSSDEYGGGTVIEQSPKS
GKTFTPDSGKKITLKVVKVTMPNLKNSTYEEAVATLKALGIASSRIKVYDGKDYSTKISSPSASSVVVGQRPYYGNTISL
TSDDDIILYVSDAVDTNTHTRAPSSSEEESTENTTTNNATTSNENTSEASSPNDS

Nucleotide


Download         Length: 1848 bp        

>NTDB_id=1171304 DYB47_RS02265 WP_003078779.1 409806..411653(+) (pknB) [Streptococcus macacae NCTC 11558]
ATGATTCAGATTGGCAAACTTTTTGCTGGTCGCTATCGAATTCTCCAATCTATTGGCCGAGGCGGAATGGCAGATGTGTA
TCTGGCTAATGATTTGATTTTAGATAATGAAGAAGTAGCGATTAAGGTGCTGCGGACAAATTATCAAACTGATCAAGTTG
CTGTTACGCGTTTTCAGCGTGAAGCGCGTGCTATGTCAGAGCTCAATCATCCAAATATTGTAGCTATCCGTGATATTGGG
GAAGAAGACGGTCAGCAGTTCCTTGCGATGGAATATGTTGACGGTGCTGATTTGAAAAAGTATATTCAGGATCATGCACC
CTTATCAAATGCTGAGGTGATCAGAATCATGAAAGAAGTTCTTTCTGCTATGACTCTGGCACATCAAAAAGGCATTATCC
ATCGAGATTTAAAACCTCAGAATGTCCTTTTAACAAAAGACGGGACAGCAAAAGTAACGGACTTTGGTATTGCTGTTGCC
TTTGCTGAAACAAGCCTAACGCAGACCAATTCTATGTTAGGTTCTGTCCATTATTTATCGCCTGAACAAGCTCGTGGTTC
GAAAGCAACTGTTCAAAGTGATATTTATGCTATGGGCATTATGCTATTTGAAATGCTGACTGGGCATATCCCTTATGATG
GCGATAGTGCCGTTACGATCGCTTTACAGCATTTTCAAAAACCGTTACCATCTATTATTAGTGAAAATAAAAATGTTCCT
CAGGCGCTTGAAAATGTTGTCATTAAAGCAACAGCTAAGCGGCTAACAGATCGGTATACATCAACTGAGGAGATGCTGCA
GGATTTAAAAACTTGTTTACAGCCAAATCGCAGCCGAGAGAGAAAGCTGATCTTTAATGATCCTTCTGATACAAAGCCTT
TGCCTAAGTTAGAACAGTCCATGACGTCATCAACAAGTGCTCAGGCTCTAAAAGATAAGGCGGCCAGCAAGGCAGCAAGT
AAAGAACCAAAAGCAAAACCAAAGAAAAAGCGGGGGCTTCTTTCTCGTCTTCTTAAACTCTTTTTTATCTTAGTCGTTCT
AGGAATTGCTGTTTTGGCTTATATGATATTAACCAAGCCGAGTACTATTTCAGTACCAAATGTTTCTGGCTATAAACTTT
CAAGCGCAAAAAGTAAGATTGTACAAGCGGGTTTGAAAGTTGGACAGGTTCGAAGAATCGAAGACGATAGTGTTGATGCT
GGTAAAGTGGTTCGTACAAATCCTAGTGCCGGCAGTAAAAAACGCGAAGGCTCTAGTGTGGATATTTTTGTATCTGGCAC
TAATAGTTTTGTGATGGAAAACTATATTGGGCAAAATTACCAAAGTGCTATAGATAATCTGACCAACACGCATGGGGTGC
CAAGGGATAATATTAGGATTAAAGAGGTCTCATCAGATGAATACGGCGGAGGAACTGTCATTGAGCAGTCCCCTAAATCT
GGAAAAACATTTACCCCAGACAGCGGTAAGAAAATTACACTCAAAGTGGTTAAAGTCACAATGCCAAATCTTAAGAATTC
AACGTATGAAGAAGCTGTTGCTACTTTGAAGGCATTAGGAATTGCTTCTAGCCGTATCAAGGTTTATGATGGAAAGGATT
ATTCGACAAAAATTTCTTCACCGTCTGCTTCTTCAGTAGTAGTTGGGCAACGCCCTTACTATGGTAATACTATCAGTCTT
ACATCTGATGATGATATTATCTTATACGTATCTGATGCTGTTGACACCAATACGCATACACGCGCACCTTCTTCATCAGA
AGAAGAAAGCACTGAAAATACGACAACTAATAATGCCACAACATCCAATGAGAATACTAGTGAAGCTAGTTCTCCTAATG
ATAGTTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(499-571)

PASTA domain (PASTA)

(364-425)

PASTA domain (PASTA)

(431-498)

Protein kinase domain (Pkinase)

(12-263)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G5JY28

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

82.669

93.821

0.776
  stkP/pknB Streptococcus salivarius strain HSISS4

63.898

95.935

0.613
  stkP Streptococcus pneumoniae TIGR4

54.329

95.772

0.52
  stkP Streptococcus pneumoniae D39

54.16

95.772

0.519
  stkP Streptococcus pneumoniae R6

54.16

95.772

0.519
  stkP Streptococcus pneumoniae Rx1

53.99

95.772

0.517

Multiple sequence alignment