Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ACLV7W_RS04540 Genome accession   NZ_OZ217346
Coordinates   928543..929280 (+) Length   245 a.a.
NCBI ID   WP_000782684.1    Uniprot ID   I0SX41
Organism   Streptococcus mitis isolate S. mitis D22     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 923543..934280
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7W_RS04530 (SMID22_09280) - 924365..926890 (+) 2526 WP_411865514.1 MBL fold metallo-hydrolase -
  ACLV7W_RS04535 (SMID22_09290) - 926940..928418 (-) 1479 WP_411865515.1 oligosaccharide flippase family protein -
  ACLV7W_RS04540 (SMID22_09300) mecA 928543..929280 (+) 738 WP_000782684.1 adaptor protein MecA Regulator
  ACLV7W_RS04545 (SMID22_09310) - 929432..930718 (+) 1287 WP_004257316.1 homoserine dehydrogenase -
  ACLV7W_RS04550 (SMID22_09320) thrB 930720..931589 (+) 870 WP_049493385.1 homoserine kinase -
  ACLV7W_RS04555 (SMID22_09330) msrB 931840..932778 (+) 939 WP_004257324.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28436.26 Da        Isoelectric Point: 4.0199

>NTDB_id=1170443 ACLV7W_RS04540 WP_000782684.1 928543..929280(+) (mecA) [Streptococcus mitis isolate S. mitis D22]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEVESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMNHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1170443 ACLV7W_RS04540 WP_000782684.1 928543..929280(+) (mecA) [Streptococcus mitis isolate S. mitis D22]
ATGAAAATGAAACAAATCAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGAGGCATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCCATCTTGGATGAGTTAGAGATGCCTGATAGCT
TTTTGGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCGGATAAGGTGGACGTATTTGTTACCAAGTCCAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGACATGGAAGAATTGGCTCAAATGTCGCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGTATCGCGGACAAAACTAAGGATGATATCGAAGCGATTCAATCTCTAGAGCAAGTCGAAGCCA
AGGAAGAAGAGCAGGAACAGGCTGAACAAGAAGTTGAGAGCAAGAAAGAGCCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTAGCTGATTTGGTGGCTTTTGCCAAGACAGTGACATTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTCTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCGTGGCTTTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGACATCAGTCGTTCAGTCTTGCAAGAGTATGGCCAAGTCTTGATGAATCACGATGCTGTGCTCAAT
CTGCAAAAAATCGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SX41

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

98.776

100

0.988
  mecA Streptococcus pneumoniae D39

98.776

100

0.988
  mecA Streptococcus pneumoniae R6

98.776

100

0.988
  mecA Streptococcus pneumoniae TIGR4

98.367

100

0.984
  mecA Streptococcus mutans UA159

48.163

100

0.482
  mecA Streptococcus thermophilus LMD-9

46.988

100

0.478
  mecA Streptococcus thermophilus LMG 18311

46.586

100

0.473

Multiple sequence alignment