Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   ACLV7D_RS09785 Genome accession   NZ_OZ217345
Coordinates   2031274..2032023 (-) Length   249 a.a.
NCBI ID   WP_164226697.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis F22     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2029936..2047181 2031274..2032023 within 0


Gene organization within MGE regions


Location: 2029936..2047181
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7D_RS09780 (SMIF22_19370) - 2029936..2031270 (-) 1335 WP_218764734.1 sensor histidine kinase -
  ACLV7D_RS09785 (SMIF22_19380) comE/blpR 2031274..2032023 (-) 750 WP_164226697.1 response regulator transcription factor Regulator
  ACLV7D_RS09790 (SMIF22_19390) - 2032020..2032367 (-) 348 WP_112444768.1 LytTR family DNA-binding domain-containing protein -
  ACLV7D_RS09795 (SMIF22_19400) - 2032551..2032937 (+) 387 WP_225904842.1 hypothetical protein -
  ACLV7D_RS09800 (SMIF22_19410) - 2033086..2034561 (-) 1476 WP_218764735.1 ABC transporter substrate-binding protein -
  ACLV7D_RS09805 (SMIF22_19420) - 2034816..2035739 (-) 924 WP_000818350.1 carbohydrate ABC transporter permease -
  ACLV7D_RS09810 (SMIF22_19430) - 2035753..2036682 (-) 930 WP_007284784.1 ABC transporter permease -
  ACLV7D_RS09815 (SMIF22_19440) - 2037552..2044349 (-) 6798 WP_411865967.1 DUF1542 domain-containing protein -
  ACLV7D_RS09820 (SMIF22_19450) - 2044944..2045378 (-) 435 WP_050252544.1 protein-export chaperone SecB -
  ACLV7D_RS09825 (SMIF22_19460) - 2045378..2045722 (-) 345 WP_050242788.1 hypothetical protein -
  ACLV7D_RS09830 (SMIF22_19470) - 2045737..2046324 (-) 588 WP_138704746.1 hypothetical protein -
  ACLV7D_RS09835 (SMIF22_19480) - 2046666..2047181 (-) 516 WP_050242789.1 hypothetical protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29285.84 Da        Isoelectric Point: 5.8701

>NTDB_id=1170395 ACLV7D_RS09785 WP_164226697.1 2031274..2032023(-) (comE/blpR) [Streptococcus mitis isolate S. mitis F22]
MNIFILEDDFIQQTRMENLVYDILEKNCWEVKHCGVYGKPNQLLEDMMERGGHQLFFLDIEIKNDVRKGLDIALEIRDRD
PNAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPESAFRERVEKAIAYVHKNKHQLMTEDSFVFTNSKALVQVPFSDLLY
IETSMIPHKLVLYSMRERIEFYGKISDILKQEPRLVQCHRSFIVNPYNISSIDKEEKLVYLKNGSSCLVSRLKMRELLNI
VKDLHDSKE

Nucleotide


Download         Length: 750 bp        

>NTDB_id=1170395 ACLV7D_RS09785 WP_164226697.1 2031274..2032023(-) (comE/blpR) [Streptococcus mitis isolate S. mitis F22]
ATGAATATCTTTATATTAGAGGATGATTTTATACAGCAGACTAGGATGGAAAATCTGGTGTATGATATTTTAGAGAAGAA
TTGTTGGGAAGTAAAGCACTGTGGTGTTTATGGTAAACCGAATCAATTGTTAGAAGATATGATGGAACGTGGAGGTCATC
AACTTTTCTTTTTGGATATTGAAATTAAAAACGATGTTAGAAAAGGGTTAGATATTGCTTTGGAAATCAGAGATAGAGAT
CCAAATGCAGTCATTGTTTTTGTAACAACTCATTCAGAATTTATGCCTGTTAGTTTTCAATATCAAGTATCAGCTTTAGA
TTTTATTGATAAGGAATTACCTGAAAGTGCTTTTAGGGAACGTGTGGAAAAGGCAATCGCTTATGTTCACAAGAATAAAC
ATCAACTAATGACTGAAGATTCTTTTGTGTTTACAAATTCTAAAGCACTCGTTCAGGTTCCGTTTTCGGATTTGCTTTAT
ATAGAAACGTCAATGATTCCTCATAAGCTAGTTCTTTATTCTATGAGAGAAAGAATAGAGTTTTACGGTAAAATTTCTGA
TATATTGAAGCAAGAACCAAGATTGGTTCAGTGTCATCGCTCTTTTATTGTGAATCCTTATAATATCTCTTCAATAGATA
AGGAAGAAAAACTAGTCTATTTGAAGAACGGGTCAAGTTGCCTAGTATCTAGGTTAAAAATGAGGGAATTGCTGAATATA
GTTAAAGATTTACATGATAGTAAGGAGTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(150-240)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

51.406

100

0.514
  comE/comE1 Streptococcus equinus JB1

42.017

95.582

0.402
  comE/comE2 Streptococcus gordonii strain NCTC7865

39.024

98.795

0.386
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

39.024

98.795

0.386
  comE/comE2 Streptococcus equinus JB1

38.115

97.992

0.373

Multiple sequence alignment