Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ACLV7D_RS04425 Genome accession   NZ_OZ217345
Coordinates   914733..915470 (+) Length   245 a.a.
NCBI ID   WP_173226724.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis F22     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 909733..920470
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7D_RS04405 (SMIF22_08630) - 909930..911033 (+) 1104 WP_173214124.1 glycosyltransferase -
  ACLV7D_RS04410 (SMIF22_08640) - 911035..912021 (+) 987 WP_164226464.1 glycosyltransferase family 2 protein -
  ACLV7D_RS04415 (SMIF22_08650) - 912037..913506 (+) 1470 WP_173214126.1 O-antigen polysaccharide polymerase Wzy family protein -
  ACLV7D_RS04420 (SMIF22_08660) - 913499..914533 (+) 1035 WP_173233375.1 prephenate dehydratase -
  ACLV7D_RS04425 (SMIF22_08670) mecA 914733..915470 (+) 738 WP_173226724.1 adaptor protein MecA Regulator
  ACLV7D_RS04430 (SMIF22_08680) - 915621..916907 (+) 1287 WP_218764612.1 homoserine dehydrogenase -
  ACLV7D_RS04435 (SMIF22_08690) thrB 916909..917778 (+) 870 WP_218764611.1 homoserine kinase -
  ACLV7D_RS04440 - 917854..918021 (+) 168 WP_225904832.1 hypothetical protein -
  ACLV7D_RS04445 (SMIF22_08700) msrB 918082..919020 (+) 939 WP_218764610.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28522.35 Da        Isoelectric Point: 4.0129

>NTDB_id=1170367 ACLV7D_RS04425 WP_173226724.1 914733..915470(+) (mecA) [Streptococcus mitis isolate S. mitis F22]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIAEKTKDDIEAIQSLEQVEAKEEEQEQAEQEVESKKEPYIYYILSFE
KLAELVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMNHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1170367 ACLV7D_RS04425 WP_173226724.1 914733..915470(+) (mecA) [Streptococcus mitis isolate S. mitis F22]
ATGAAAATGAAACAAATTAGTGATACAACTTTGAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTTGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTAACCAAATCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTACCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCAGAAAAGACTAAAGATGATATCGAAGCGATTCAATCTCTAGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAGGAACAGGCTGAACAAGAAGTTGAAAGTAAGAAAGAGCCTTACATCTATTACATCCTTTCTTTTGAA
AAATTAGCTGAGTTGGTGGCTTTTGCCAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACTATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTGTTGGCTCGTATGCGTGAGT
TTGCGGACGATAGTGACATCAGTCGCTCGGTCTTGCAAGAGTATGGTCAAGTCTTGATGAATCACGATGCAGTACTTAAT
CTGCAAAAGATTGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

97.551

100

0.976
  mecA Streptococcus pneumoniae D39

97.551

100

0.976
  mecA Streptococcus pneumoniae R6

97.551

100

0.976
  mecA Streptococcus pneumoniae TIGR4

97.143

100

0.971
  mecA Streptococcus mutans UA159

48.571

100

0.486
  mecA Streptococcus thermophilus LMD-9

46.586

100

0.473
  mecA Streptococcus thermophilus LMG 18311

46.185

100

0.469

Multiple sequence alignment