Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   ACLV7D_RS02595 Genome accession   NZ_OZ217345
Coordinates   486180..488159 (+) Length   659 a.a.
NCBI ID   WP_218764349.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis F22     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 481180..493159
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7D_RS02580 (SMIF22_05000) fmt 483187..484122 (+) 936 WP_166731951.1 methionyl-tRNA formyltransferase -
  ACLV7D_RS02585 (SMIF22_05010) rsmB 484115..485428 (+) 1314 WP_218764348.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  ACLV7D_RS02590 (SMIF22_05020) - 485443..486183 (+) 741 WP_000406237.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ACLV7D_RS02595 (SMIF22_05030) stkP 486180..488159 (+) 1980 WP_218764349.1 serine/threonine-protein kinase StkP Regulator
  ACLV7D_RS02600 (SMIF22_05040) - 488274..489032 (+) 759 WP_218764350.1 threonine/serine exporter family protein -
  ACLV7D_RS02605 (SMIF22_05050) - 489034..489483 (+) 450 WP_057487161.1 threonine/serine exporter family protein -
  ACLV7D_RS02610 (SMIF22_05060) - 489642..489890 (+) 249 WP_057487170.1 hypothetical protein -
  ACLV7D_RS02615 (SMIF22_05070) - 490021..491193 (+) 1173 WP_050252772.1 hydroxymethylglutaryl-CoA synthase -
  ACLV7D_RS02620 (SMIF22_05080) - 491193..492467 (+) 1275 WP_218764351.1 hydroxymethylglutaryl-CoA reductase, degradative -

Sequence

Protein


Download         Length: 659 a.a.        Molecular weight: 72423.07 Da        Isoelectric Point: 9.2168

>NTDB_id=1170357 ACLV7D_RS02595 WP_218764349.1 486180..488159(+) (stkP) [Streptococcus mitis isolate S. mitis F22]
MIQIGKIFAGRYRIIKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVIIKATAKKLTDRYKSVAEMYVDLSSSLSYNRRNEPKLVFDDATKADTKTLPKVSQSTLTSIPKVQSQTEHKPIK
KTSQTVTEETYQPQAPKKRRFKMRYLIFLASIVLVAASLIWILSRTPATISIPDVAGQTVAEAKETLKKANFEIGEEKSE
ASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESKESEAGTV
MKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAG
IPYDLSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVSTAPAGTAEGTVVEQSPRAGEKVDL
NKTRVKISIYKPKTSSATP

Nucleotide


Download         Length: 1980 bp        

>NTDB_id=1170357 ACLV7D_RS02595 WP_218764349.1 486180..488159(+) (stkP) [Streptococcus mitis isolate S. mitis F22]
ATGATCCAAATCGGCAAGATTTTTGCCGGACGCTATCGGATTATCAAACAGATTGGTCGAGGAGGCATGGCAGATGTCTA
TTTGGCCAAAGATTTGATTCTAGATGGGGAAGAAGTGGCAGTGAAGGTTCTGAGAACCAACTACCAGACGGACCCGATAG
CTGTAGCTCGTTTTCAGCGTGAAGCGAGAGCTATGGCAGATTTAGACCATCCTCATATCGTTCGGATAACAGATATTGGC
GAGGAAGACGGTCAACAGTACCTAGCTATGGAGTATGTTGCTGGACTTGACCTTAAACGCTATATCAAGGAACACTATCC
TCTTTCTAATGAAGAAGCCGTCCGTATCATGGGACAAATTCTTCTCGCCATGCGTTTGGCTCATACCAGAGGAATTGTTC
ACAGAGACTTGAAACCTCAAAATATTCTCTTGACACCAGATGGTACAGCCAAGGTTACAGACTTTGGGATTGCAGTAGCC
TTTGCTGAGACAAGTCTGACTCAGACTAACTCTATGCTGGGCTCAGTTCATTACTTGTCACCAGAGCAGGCGCGTGGCTC
TAAGGCGACTGTACAAAGTGATATCTATGCCATGGGGATTATTTTCTATGAGATGCTGACAGGTCATATTCCTTACGATG
GAGATAGTGCGGTGACCATCGCCCTCCAGCATTTCCAAAAGCCCCTGCCGTCCGTTATTGCTGAGAATCCATCAGTACCT
CAGGCTTTAGAGAATGTTATTATCAAGGCAACTGCTAAGAAATTGACAGATCGCTATAAATCAGTTGCTGAAATGTATGT
GGATTTGTCTAGTAGTTTGTCTTATAATCGTCGTAATGAACCAAAGCTGGTCTTTGACGATGCGACTAAGGCAGATACCA
AGACTCTACCAAAAGTATCCCAGAGCACCTTGACTTCGATTCCTAAGGTGCAATCGCAGACAGAACACAAACCAATCAAA
AAAACAAGTCAGACTGTGACAGAGGAAACTTACCAACCACAAGCACCGAAAAAACGTAGATTTAAGATGCGTTACCTGAT
TTTTTTGGCCAGCATTGTATTGGTGGCAGCTTCTCTGATTTGGATACTATCCAGAACTCCTGCAACCATTTCTATTCCAG
ATGTGGCAGGTCAGACAGTTGCGGAAGCCAAGGAAACGCTCAAAAAAGCCAATTTTGAGATTGGAGAGGAGAAGTCAGAG
GCCAGTGAAAAGGTGGAGGAAGGGCGGATTATCCGTACAGATCCTGGCGCTGGAACTGGTCGAAAAGAAGGAACGAAAAT
CAATTTGGTTGTCTCATCAGGCAAGCAATCCTTCCAAATTAGTAATTATGTCGGTCGGAAATCCTCTGATGTCATTGCGG
AATTAAAAGAGAAAAAAGTTCCAGATAATTTGATTAAAATTGAGGAAGAAGAGTCCAAGGAGAGTGAGGCTGGAACGGTC
ATGAAACAAAGTCTACCAGAAGGTACGACCTATGACTTGAGCAAGGCAACTCAAATTGTTTTGACAGTAGCTAAAAAAGC
TACGACGATTCAATTAGGGAACTATATTGGACGGAACTCTACAGAAGTCATCTCGGAACTCAAGCAGAAGAAGGTTCCTG
AGAATTTGATTAAGATAGAGGAAGAAGAGTCCAGCGAAAGCGAACCAGGAACGATTATGAAACAAAGTCCAGGTGCAGGT
ATCCCTTATGATTTGAGTAAACCTACTCAAATCGTCTTGACAGTAGCTAAAAAAGTTACAAGTGTTGCCATGCCGAGCTA
CATTGGTTCCAGCTTGGAGTTTACTAAGAATAATTTGATTCAAATTGTTGGGATTAAGGAAGCCAATATAGAAGTTGTAG
AAGTGTCGACAGCTCCCGCTGGAACTGCTGAAGGTACAGTCGTTGAACAAAGTCCTAGAGCAGGTGAAAAGGTAGACCTC
AATAAGACTAGAGTCAAGATTTCAATCTACAAACCTAAAACAAGTTCAGCTACTCCTTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-227)

PASTA domain (PASTA)

(513-577)

PASTA domain (PASTA)

(372-432)

PASTA domain (PASTA)

(440-505)

PASTA domain (PASTA)

(582-651)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

95.599

100

0.956
  stkP Streptococcus pneumoniae D39

95.144

100

0.951
  stkP Streptococcus pneumoniae R6

95.144

100

0.951
  stkP Streptococcus pneumoniae Rx1

94.992

100

0.95
  pknB Streptococcus mutans UA159

54.017

88.771

0.48
  stkP/pknB Streptococcus salivarius strain HSISS4

58.502

74.962

0.439

Multiple sequence alignment