Detailed information NTG1170313

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACLV7A_RS09475
• Genome accession: NZ_OZ217344
• Coordinates: 1956385..1957134 (-)
• Length: 249 a.a.
• NCBI ID: WP_173253425.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis E22
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1955047..1969992	1956385..1957134	within	0

Gene organization within MGE regions

Location: 1955047..1969992

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7A_RS09470 (SMIE22_18920)	-	1955047..1956381 (-)	1335	WP_218757325.1	sensor histidine kinase	-
ACLV7A_RS09475 (SMIE22_18930)	comE/blpR	1956385..1957134 (-)	750	WP_173253425.1	response regulator transcription factor	Regulator
ACLV7A_RS09480 (SMIE22_18940)	-	1957131..1957478 (-)	348	WP_112444768.1	LytTR family DNA-binding domain-containing protein	-
ACLV7A_RS09485 (SMIE22_18960)	-	1958197..1959672 (-)	1476	WP_411864159.1	ABC transporter substrate-binding protein	-
ACLV7A_RS09490 (SMIE22_18970)	-	1959927..1960850 (-)	924	WP_000818350.1	carbohydrate ABC transporter permease	-
ACLV7A_RS09495 (SMIE22_18980)	-	1960864..1961793 (-)	930	WP_050223181.1	ABC transporter permease	-
ACLV7A_RS09500 (SMIE22_18990)	-	1962661..1969992 (-)	7332	WP_411864160.1	YSIRK-type signal peptide-containing protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29301.84 Da
• Isoelectric Point: 5.8701

>NTDB_id=1170313 ACLV7A_RS09475 WP_173253425.1 1956385..1957134(-) (comE/blpR) [Streptococcus mitis isolate S. mitis E22]
MNIFILEDDFIQQTRMENLVYDILEKNCWEVKHCGVYGKPNQLLEDMMERGGHQLFFLDIEIKNDVRKGLDIALEIRDRD
PNAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPESSFRERVEKAIAYVHKNKHQLMTEDSFVFTNSKALVQVPFSDLLY
IETSMIPHKLVLYSMRERIEFYGKISDILKQEPRLVQCHRSFIVNPYNISSIDKEEKLVYLKNGSSCLVSRLKMRELLNI
VKDLHDSKE

Nucleotide

• Length: 750 bp

>NTDB_id=1170313 ACLV7A_RS09475 WP_173253425.1 1956385..1957134(-) (comE/blpR) [Streptococcus mitis isolate S. mitis E22]
ATGAATATCTTTATATTAGAGGATGATTTTATACAGCAGACTAGGATGGAAAATCTGGTGTATGATATTTTAGAGAAGAA
TTGTTGGGAAGTAAAGCACTGTGGTGTTTATGGTAAACCGAATCAATTGTTAGAAGATATGATGGAACGTGGAGGTCATC
AACTTTTCTTTTTGGATATTGAAATTAAAAACGATGTTAGAAAAGGGTTAGATATTGCTTTGGAAATCAGAGATAGAGAT
CCAAATGCAGTCATTGTTTTTGTAACAACTCATTCAGAATTTATGCCTGTTAGTTTTCAATATCAAGTATCAGCTTTAGA
TTTTATTGATAAGGAATTACCTGAAAGCTCTTTTAGGGAACGTGTGGAAAAGGCAATCGCTTATGTTCACAAGAATAAAC
ATCAACTAATGACTGAAGATTCTTTTGTGTTTACAAATTCTAAAGCACTCGTTCAGGTTCCGTTTTCGGATTTGCTTTAT
ATAGAAACGTCAATGATTCCTCATAAGCTAGTTCTTTATTCTATGAGAGAAAGAATAGAGTTTTACGGTAAAATTTCTGA
TATATTGAAGCAAGAACCCAGATTGGTTCAGTGTCATCGTTCTTTTATTGTGAATCCTTATAATATCTCTTCAATAGATA
AGGAAGAAAAACTAGTCTATTTGAAGAACGGGTCAAGTTGCCTAGTATCTAGGTTAAAAATGAGGGAATTGCTGAATATA
GTTAAAGATTTACATGATAGTAAGGAGTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (150-240)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	51.406	100	0.514
comE/comE1	Streptococcus equinus JB1	41.597	95.582	0.398
comE/comE2	Streptococcus gordonii strain NCTC7865	39.431	98.795	0.39
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.431	98.795	0.39
comE/comE2	Streptococcus equinus JB1	37.705	97.992	0.369