Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   ACLV7A_RS03970 Genome accession   NZ_OZ217344
Coordinates   824915..825649 (+) Length   244 a.a.
NCBI ID   WP_411863658.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis E22     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 819915..830649
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS03950 (SMIE22_07730) - 819997..821100 (+) 1104 WP_173270240.1 glycosyltransferase -
  ACLV7A_RS03955 (SMIE22_07740) - 821102..822088 (+) 987 WP_173270238.1 glycosyltransferase -
  ACLV7A_RS03960 (SMIE22_07750) - 822104..823573 (+) 1470 WP_050389933.1 O-antigen polysaccharide polymerase Wzy family protein -
  ACLV7A_RS03965 (SMIE22_07760) - 823566..824600 (+) 1035 WP_411863657.1 prephenate dehydratase -
  ACLV7A_RS03970 (SMIE22_07770) mecA 824915..825649 (+) 735 WP_411863658.1 adaptor protein MecA Regulator
  ACLV7A_RS03975 (SMIE22_07780) - 825796..827082 (+) 1287 WP_411863659.1 homoserine dehydrogenase -
  ACLV7A_RS03980 (SMIE22_07790) thrB 827084..827953 (+) 870 WP_411863660.1 homoserine kinase -
  ACLV7A_RS03985 (SMIE22_07800) msrB 828167..829105 (+) 939 WP_218758041.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 244 a.a.        Molecular weight: 28323.10 Da        Isoelectric Point: 4.0020

>NTDB_id=1170285 ACLV7A_RS03970 WP_411863658.1 824915..825649(+) (mecA) [Streptococcus mitis isolate S. mitis E22]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQQEVESKKEPYIYYILSFAKL
ADLVAFAQTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMNHDAVLNLQ
KIGS

Nucleotide


Download         Length: 735 bp        

>NTDB_id=1170285 ACLV7A_RS03970 WP_411863658.1 824915..825649(+) (mecA) [Streptococcus mitis isolate S. mitis E22]
ATGAAAATGAAACAAATTAGTGATACAACTTTGAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGCATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TCCTAGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTAACCAAATCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTACCAGATATGGAAGAATTGGCTCAAATGTCACCAGATGAATTTAT
CAAAACCTTGGAAAAAAGCATCGCAGATAAAACTAAGGATGATATCGAAGCGATTCAATCTCTAGAGCAAGTCGAAGCCA
AGGAAGAAGAGCAGGAACAACAAGAAGTTGAAAGCAAGAAAGAGCCTTACATCTATTACATCCTTTCTTTTGCTAAGTTG
GCTGACTTGGTGGCTTTTGCCCAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCGCTATTA
TTTGACCATTTTAGTAGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTGTTGGCTCGTATGCGCGAGTTTGCGG
ACGATAGTGACATCAGTCGCTCGGTCTTGCAAGAGTATGGCCAAGTCTTGATGAATCACGATGCAGTGCTCAATCTGCAA
AAGATTGGTTCATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-237)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

97.551

100

0.98
  mecA Streptococcus pneumoniae D39

97.551

100

0.98
  mecA Streptococcus pneumoniae R6

97.551

100

0.98
  mecA Streptococcus pneumoniae TIGR4

97.143

100

0.975
  mecA Streptococcus mutans UA159

48.571

100

0.488
  mecA Streptococcus thermophilus LMD-9

47.39

100

0.484
  mecA Streptococcus thermophilus LMG 18311

46.988

100

0.48

Multiple sequence alignment