Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   ACLV7A_RS02290 Genome accession   NZ_OZ217344
Coordinates   436879..438780 (+) Length   633 a.a.
NCBI ID   WP_411863482.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis E22     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 431879..443780
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS02275 (SMIE22_04420) fmt 433886..434821 (+) 936 WP_411863479.1 methionyl-tRNA formyltransferase -
  ACLV7A_RS02280 (SMIE22_04430) rsmB 434814..436127 (+) 1314 WP_411863480.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  ACLV7A_RS02285 (SMIE22_04440) - 436142..436882 (+) 741 WP_411863481.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  ACLV7A_RS02290 (SMIE22_04450) stkP 436879..438780 (+) 1902 WP_411863482.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  ACLV7A_RS02295 (SMIE22_04460) - 438869..439627 (+) 759 WP_411863483.1 threonine/serine exporter family protein -
  ACLV7A_RS02300 (SMIE22_04470) - 439629..440078 (+) 450 WP_000176928.1 threonine/serine exporter family protein -
  ACLV7A_RS02305 (SMIE22_04480) - 440191..441363 (+) 1173 WP_411863484.1 hydroxymethylglutaryl-CoA synthase -
  ACLV7A_RS02310 (SMIE22_04490) - 441363..442637 (+) 1275 WP_411863485.1 hydroxymethylglutaryl-CoA reductase, degradative -

Sequence

Protein


Download         Length: 633 a.a.        Molecular weight: 69197.76 Da        Isoelectric Point: 9.4704

>NTDB_id=1170276 ACLV7A_RS02290 WP_411863482.1 436879..438780(+) (stkP) [Streptococcus mitis isolate S. mitis E22]
MIQIGKIFAGRYRIIKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVIIKATAKKLTDRYKSVAEMYVDLSSSLSYNRRNEPKLVFDDATKADTKTLPKVSQSTLTSIPKVQAQTEHKPIK
KPSQAVTEETYQPQAPKKRRFKMRYLIFLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKETLKKANFEIGEEKSE
ASEKVEEGRIIRTDPGARTGRKEGTKINLVVSSGKQSFQISNYVGRKSTDVIAELKQKKVPENLIKIEEEESSESEAGTV
LRQSPAAGTTYDLSKASTITLTVAKKVTSVAMPSYIGSSLEFTKNNLVQIVGIKEANIEVVEVSTAPDGTAEGTVVEQSP
KAGEKVDLTKTRVKISIYKPKTPPSTSSSAPAQRGNQGSTTTPSQGNQQGNQRGNVPATTQSSSEGNHENSRD

Nucleotide


Download         Length: 1902 bp        

>NTDB_id=1170276 ACLV7A_RS02290 WP_411863482.1 436879..438780(+) (stkP) [Streptococcus mitis isolate S. mitis E22]
ATGATCCAAATCGGCAAGATTTTTGCCGGACGCTATCGGATTATCAAACAGATTGGTCGAGGAGGCATGGCAGATGTTTA
CTTGGCCAAAGATTTGATTCTAGATGGGGAAGAAGTGGCAGTGAAGGTTCTGAGAACCAACTACCAGACAGACCCGATAG
CTGTAGCTCGTTTTCAGCGTGAAGCGAGAGCTATGGCAGATTTAGACCATCCTCATATCGTTCGGATAACAGATATTGGC
GAGGAAGACGGTCAACAGTACCTCGCTATGGAGTATGTGGCTGGACTTGACCTTAAACGCTATATCAAGGAACACTATCC
CCTTTCTAATGAAGAAGCCGTCCGTATAATGGGACAAATTCTCTTGGCTATGCGTTTGGCCCATACCAGAGGAATTGTTC
ACCGGGACTTGAAACCTCAGAACATCCTCTTGACACCAGATGGGACAGCCAAGGTCACAGACTTTGGGATTGCAGTAGCC
TTTGCTGAGACAAGTCTGACTCAGACTAACTCGATGCTGGGTTCGGTGCATTACTTGTCACCAGAGCAGGCGCGTGGCTC
TAAGGCGACTGTGCAGAGTGATATCTATGCCATGGGGATTATTTTCTATGAGATGCTGACAGGCCATATCCCTTACGATG
GGGATAGCGCGGTGACCATTGCCCTCCAGCATTTCCAAAAACCCCTGCCGTCCGTTATTGCTGAGAATCCATCAGTACCT
CAGGCTTTAGAGAATGTTATTATCAAGGCAACTGCTAAGAAATTGACAGATCGCTATAAATCAGTTGCTGAAATGTATGT
GGATTTGTCTAGTAGTTTGTCTTATAATCGTCGTAATGAACCAAAGCTGGTCTTTGACGATGCGACCAAGGCGGACACCA
AGACTCTACCAAAAGTATCCCAGAGCACCTTGACTTCGATTCCTAAGGTTCAAGCGCAGACAGAACACAAACCAATCAAA
AAACCAAGCCAGGCCGTGACAGAGGAAACTTACCAACCACAAGCACCGAAAAAACGTAGATTTAAGATGCGTTACCTGAT
TTTTTTGGCCAGCCTTGTATTGGTGGCAGCCTCTCTTATTTGGATACTATCCAGAACTCCTGCAACCATTGCCATTCCAG
ATGTGGCAGGTCAGACAGTTGCGGAAGCCAAGGAAACGCTCAAGAAAGCCAATTTTGAGATTGGCGAGGAGAAGTCAGAG
GCTAGTGAAAAGGTGGAAGAGGGGCGGATTATCCGTACAGATCCTGGCGCTAGAACTGGTCGAAAAGAAGGAACGAAAAT
CAATTTGGTTGTCTCATCAGGCAAGCAATCTTTCCAAATTAGTAATTATGTCGGACGTAAATCCACAGATGTTATTGCAG
AACTCAAGCAGAAGAAGGTTCCTGAAAATCTCATCAAGATTGAGGAAGAAGAATCAAGTGAGAGCGAAGCAGGAACCGTT
CTCAGACAGAGTCCAGCTGCCGGAACAACCTATGATTTGAGCAAGGCCTCAACGATTACCTTAACCGTTGCTAAGAAAGT
AACCAGCGTTGCTATGCCAAGTTATATAGGATCTAGTCTTGAATTTACTAAAAATAATCTCGTTCAAATTGTCGGTATTA
AAGAAGCCAATATTGAAGTTGTAGAAGTGTCGACAGCTCCTGATGGAACTGCTGAGGGGACTGTTGTAGAGCAAAGTCCA
AAAGCAGGCGAAAAGGTTGATTTGACTAAGACGCGTGTCAAGATTTCAATTTACAAACCAAAAACACCGCCGTCAACGTC
ATCATCAGCACCAGCCCAACGTGGAAACCAAGGTTCTACTACGACACCAAGTCAGGGGAACCAACAAGGAAATCAACGAG
GGAATGTACCTGCTACTACTCAATCAAGTAGTGAAGGGAACCACGAAAATTCTCGTGATTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-227)

PASTA domain (PASTA)

(510-579)

PASTA domain (PASTA)

(371-432)

PASTA domain (PASTA)

(440-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

85.154

92.575

0.788
  stkP Streptococcus pneumoniae D39

84.812

92.575

0.785
  stkP Streptococcus pneumoniae R6

84.812

92.575

0.785
  stkP Streptococcus pneumoniae Rx1

84.642

92.575

0.784
  stkP/pknB Streptococcus salivarius strain HSISS4

53.716

93.523

0.502
  pknB Streptococcus mutans UA159

54.939

91.153

0.501

Multiple sequence alignment